Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly

Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly

Significant morphological changes occur during the conversion of the immature HIV virion into a mature infectious form. Here the authors use coarse-grained molecular dynamics simulations to model HIV-1 capsid self-assembly and disassembly events that suggests several metastable capsid intermediates...

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Autores principales: John M. A. Grime, James F. Dama, Barbie K. Ganser-Pornillos, Cora L. Woodward, Grant J. Jensen, Mark Yeager, Gregory A. Voth
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/cb54a296583545b2ab2085fab3f7c41c
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spelling oai:doaj.org-article:cb54a296583545b2ab2085fab3f7c41c2021-12-02T15:35:41ZCoarse-grained simulation reveals key features of HIV-1 capsid self-assembly10.1038/ncomms115682041-1723https://doaj.org/article/cb54a296583545b2ab2085fab3f7c41c2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11568https://doaj.org/toc/2041-1723Significant morphological changes occur during the conversion of the immature HIV virion into a mature infectious form. Here the authors use coarse-grained molecular dynamics simulations to model HIV-1 capsid self-assembly and disassembly events that suggests several metastable capsid intermediates sensitive to local conditions.John M. A. GrimeJames F. DamaBarbie K. Ganser-PornillosCora L. WoodwardGrant J. JensenMark YeagerGregory A. VothNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
John M. A. Grime
James F. Dama
Barbie K. Ganser-Pornillos
Cora L. Woodward
Grant J. Jensen
Mark Yeager
Gregory A. Voth
Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
description Significant morphological changes occur during the conversion of the immature HIV virion into a mature infectious form. Here the authors use coarse-grained molecular dynamics simulations to model HIV-1 capsid self-assembly and disassembly events that suggests several metastable capsid intermediates sensitive to local conditions.
format article
author John M. A. Grime
James F. Dama
Barbie K. Ganser-Pornillos
Cora L. Woodward
Grant J. Jensen
Mark Yeager
Gregory A. Voth
author_facet John M. A. Grime
James F. Dama
Barbie K. Ganser-Pornillos
Cora L. Woodward
Grant J. Jensen
Mark Yeager
Gregory A. Voth
author_sort John M. A. Grime
title Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
title_short Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
title_full Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
title_fullStr Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
title_full_unstemmed Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly
title_sort coarse-grained simulation reveals key features of hiv-1 capsid self-assembly
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/cb54a296583545b2ab2085fab3f7c41c
work_keys_str_mv AT johnmagrime coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
AT jamesfdama coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
AT barbiekganserpornillos coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
AT coralwoodward coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
AT grantjjensen coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
AT markyeager coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
AT gregoryavoth coarsegrainedsimulationrevealskeyfeaturesofhiv1capsidselfassembly
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