Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.

<h4>Purpose</h4>Many studies of MRI radiomics do not include the discretization method used for the analyses, which might indicate that the discretization methods used are considered irrelevant. Our goals were to compare three frequently used discretization methods (lesion relative resam...

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Autores principales:	Gergő Veres, Norman Félix Vas, Martin Lyngby Lassen, Monika Béresová, Aron K Krizsan, Attila Forgács, Ervin Berényi, László Balkay
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb5663082777476fa47375974038b7b6
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spelling	oai:doaj.org-article:cb5663082777476fa47375974038b7b62021-12-02T20:10:23ZEffect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.1932-620310.1371/journal.pone.0253419https://doaj.org/article/cb5663082777476fa47375974038b7b62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253419https://doaj.org/toc/1932-6203<h4>Purpose</h4>Many studies of MRI radiomics do not include the discretization method used for the analyses, which might indicate that the discretization methods used are considered irrelevant. Our goals were to compare three frequently used discretization methods (lesion relative resampling (LRR), lesion absolute resampling (LAR) and absolute resampling (AR)) applied to the same data set, along with two different lesion segmentation approaches.<h4>Methods</h4>We analyzed the effects of altering bin widths or bin numbers for the three different sampling methods using 40 texture indices (TIs). The impact was evaluated on brain MRI studies obtained for 71 patients divided into three different disease groups: multiple sclerosis (MS, N = 22), ischemic stroke (IS, N = 22), cancer patients (N = 27). Two different MRI acquisition protocols were considered for all patients, a T2- and a post-contrast 3D T1-weighted MRI sequence. Elliptical and manually drawn VOIs were employed for both imaging series. Three different types of gray-level discretization methods were used: LRR, LAR and AR. Hypothesis tests were done among all diseased and control areas to compare the TI values in these areas. We also did correlation analyses between TI values and lesion volumes.<h4>Results</h4>In general, no significant differences were reported in the results when employing the AR and LAR discretization methods. It was found that employing 38 TIs introduced variation in the results when the number of bin parameters was altered, suggesting that both the degree and direction of monotonicity between each TI value and binning parameters were characteristic for each TI. Furthermore, while TIs were changing with altering binning values, no changes correlated to neither disease nor the MRI sequence. We found that most indices correlated weakly with the volume, while the correlation coefficients were independent of both diseases analyzed and MR contrast. Several cooccurrence-matrix based texture parameters show a definite higher correlation when employing the LRR discretization method However, with the best correlations obtained for the manually drawn VOI. Hypothesis tests among all disease and control areas (co-lateral hemisphere) revealed that the AR or LAR discretization techniques provide more suitable texture features than LRR. In addition, the manually drawn segmentation gave fewer significantly different TIs than the ellipsoid segmentations. In addition, the amount of TIs with significant differences was increasing with increasing the number of bins, or decreasing bin widths.<h4>Conclusion</h4>Our findings indicate that the AR discretization method may offer the best texture analysis in MR image assessments. Employing too many bins or too large bin widths might reduce the selection of TIs that can be used for differential diagnosis. In general, more statistically different TIs were observed for elliptical segmentations when compared to the manually drawn VOIs. In the texture analysis of MR studies, studies and publications should report on all important parameters and methods related to data collection, corrections, normalization, discretization, and segmentation.Gergő VeresNorman Félix VasMartin Lyngby LassenMonika BéresováAron K KrizsanAttila ForgácsErvin BerényiLászló BalkayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253419 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gergő Veres Norman Félix Vas Martin Lyngby Lassen Monika Béresová Aron K Krizsan Attila Forgács Ervin Berényi László Balkay Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.
description	<h4>Purpose</h4>Many studies of MRI radiomics do not include the discretization method used for the analyses, which might indicate that the discretization methods used are considered irrelevant. Our goals were to compare three frequently used discretization methods (lesion relative resampling (LRR), lesion absolute resampling (LAR) and absolute resampling (AR)) applied to the same data set, along with two different lesion segmentation approaches.<h4>Methods</h4>We analyzed the effects of altering bin widths or bin numbers for the three different sampling methods using 40 texture indices (TIs). The impact was evaluated on brain MRI studies obtained for 71 patients divided into three different disease groups: multiple sclerosis (MS, N = 22), ischemic stroke (IS, N = 22), cancer patients (N = 27). Two different MRI acquisition protocols were considered for all patients, a T2- and a post-contrast 3D T1-weighted MRI sequence. Elliptical and manually drawn VOIs were employed for both imaging series. Three different types of gray-level discretization methods were used: LRR, LAR and AR. Hypothesis tests were done among all diseased and control areas to compare the TI values in these areas. We also did correlation analyses between TI values and lesion volumes.<h4>Results</h4>In general, no significant differences were reported in the results when employing the AR and LAR discretization methods. It was found that employing 38 TIs introduced variation in the results when the number of bin parameters was altered, suggesting that both the degree and direction of monotonicity between each TI value and binning parameters were characteristic for each TI. Furthermore, while TIs were changing with altering binning values, no changes correlated to neither disease nor the MRI sequence. We found that most indices correlated weakly with the volume, while the correlation coefficients were independent of both diseases analyzed and MR contrast. Several cooccurrence-matrix based texture parameters show a definite higher correlation when employing the LRR discretization method However, with the best correlations obtained for the manually drawn VOI. Hypothesis tests among all disease and control areas (co-lateral hemisphere) revealed that the AR or LAR discretization techniques provide more suitable texture features than LRR. In addition, the manually drawn segmentation gave fewer significantly different TIs than the ellipsoid segmentations. In addition, the amount of TIs with significant differences was increasing with increasing the number of bins, or decreasing bin widths.<h4>Conclusion</h4>Our findings indicate that the AR discretization method may offer the best texture analysis in MR image assessments. Employing too many bins or too large bin widths might reduce the selection of TIs that can be used for differential diagnosis. In general, more statistically different TIs were observed for elliptical segmentations when compared to the manually drawn VOIs. In the texture analysis of MR studies, studies and publications should report on all important parameters and methods related to data collection, corrections, normalization, discretization, and segmentation.
format	article
author	Gergő Veres Norman Félix Vas Martin Lyngby Lassen Monika Béresová Aron K Krizsan Attila Forgács Ervin Berényi László Balkay
author_facet	Gergő Veres Norman Félix Vas Martin Lyngby Lassen Monika Béresová Aron K Krizsan Attila Forgács Ervin Berényi László Balkay
author_sort	Gergő Veres
title	Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.
title_short	Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.
title_full	Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.
title_fullStr	Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.
title_full_unstemmed	Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.
title_sort	effect of grey-level discretization on texture feature on different weighted mri images of diverse disease groups.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/cb5663082777476fa47375974038b7b6
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_version_	1718375025165205504

Effect of grey-level discretization on texture feature on different weighted MRI images of diverse disease groups.

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