Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?

Grazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia LazzariRadiation Oncology Unit, San Giuseppe...

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Autores principales:	Lazzari G, Buono G, Zannino B, Silvano G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	radiation radiosensitivity tumor suppressor genes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cb58ab0776f14abcbf70ba335c8c3fa1
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spelling	oai:doaj.org-article:cb58ab0776f14abcbf70ba335c8c3fa12021-12-02T15:19:13ZBreast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?1179-1314https://doaj.org/article/cb58ab0776f14abcbf70ba335c8c3fa12021-05-01T00:00:00Zhttps://www.dovepress.com/breast-cancer-adjuvant-radiotherapy-in-brca12-tp53-atm-genes-mutations-peer-reviewed-fulltext-article-BCTThttps://doaj.org/toc/1179-1314Grazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia LazzariRadiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, ItalyEmail lazzarigrazia@gmail.comAbstract: BRCA1, BRCA2, TP53 and ATM gene mutations are the most studied tumour suppressor genes (TSGs) influencing the loco-regional approach to breast cancer (BC). Due to altered radio sensitivity of mutated cancer cells, mastectomy has always been advised in most patients with BC linked to TSGs mutations in order to avoid or minimize the use of adjuvant radiotherapy (ART). Whether ART is safe or not in these carriers is still debated. As a result, this issue has been widely discussed in the recent ASTRO and ASCO papers, yielding important and useful recommendations on the use of ART according to the mutational status. In this review, we have highlighted the impact of these mutations on local control, toxicities, second tumors, and contralateral breast cancers (CBCs) after ART to solve remaining doubts and encourage the safe use of ART when indicated.Keywords: radiation, radiosensitivity, tumor suppressor genesLazzari GBuono GZannino BSilvano GDove Medical Pressarticleradiationradiosensitivitytumor suppressor genesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 299-310 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiation radiosensitivity tumor suppressor genes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	radiation radiosensitivity tumor suppressor genes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lazzari G Buono G Zannino B Silvano G Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
description	Grazia Lazzari,1 Giuseppe Buono,2 Benedetto Zannino,2 Giovanni Silvano1 1Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, Italy; 2Medical Oncology Unit, San Rocco Hospital, Sessa Aurunca, Caserta, 81037, ItalyCorrespondence: Grazia LazzariRadiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, 74100, ItalyEmail lazzarigrazia@gmail.comAbstract: BRCA1, BRCA2, TP53 and ATM gene mutations are the most studied tumour suppressor genes (TSGs) influencing the loco-regional approach to breast cancer (BC). Due to altered radio sensitivity of mutated cancer cells, mastectomy has always been advised in most patients with BC linked to TSGs mutations in order to avoid or minimize the use of adjuvant radiotherapy (ART). Whether ART is safe or not in these carriers is still debated. As a result, this issue has been widely discussed in the recent ASTRO and ASCO papers, yielding important and useful recommendations on the use of ART according to the mutational status. In this review, we have highlighted the impact of these mutations on local control, toxicities, second tumors, and contralateral breast cancers (CBCs) after ART to solve remaining doubts and encourage the safe use of ART when indicated.Keywords: radiation, radiosensitivity, tumor suppressor genes
format	article
author	Lazzari G Buono G Zannino B Silvano G
author_facet	Lazzari G Buono G Zannino B Silvano G
author_sort	Lazzari G
title	Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
title_short	Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
title_full	Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
title_fullStr	Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
title_full_unstemmed	Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?
title_sort	breast cancer adjuvant radiotherapy in brca1/2, tp53, atm genes mutations: are there solved issues?
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/cb58ab0776f14abcbf70ba335c8c3fa1
work_keys_str_mv	AT lazzarig breastcanceradjuvantradiotherapyinbrca12tp53atmgenesmutationsaretheresolvedissues AT buonog breastcanceradjuvantradiotherapyinbrca12tp53atmgenesmutationsaretheresolvedissues AT zanninob breastcanceradjuvantradiotherapyinbrca12tp53atmgenesmutationsaretheresolvedissues AT silvanog breastcanceradjuvantradiotherapyinbrca12tp53atmgenesmutationsaretheresolvedissues
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Breast Cancer Adjuvant Radiotherapy in BRCA1/2, TP53, ATM Genes Mutations: Are There Solved Issues?

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