Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions
Interferons (IFNs) are cytokines that possess antiviral, antiproliferative, and immunomodulatory actions. IFN-α and IFN-β are two major family members of type-I IFNs and are used to treat diseases, including hepatitis and multiple sclerosis. Emerging evidence suggests that type-I IFN receptors (IFNA...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:cb603e0b63304077bd4b817fefca081e2021-11-05T07:13:33ZInterferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions1664-322410.3389/fimmu.2021.783725https://doaj.org/article/cb603e0b63304077bd4b817fefca081e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.783725/fullhttps://doaj.org/toc/1664-3224Interferons (IFNs) are cytokines that possess antiviral, antiproliferative, and immunomodulatory actions. IFN-α and IFN-β are two major family members of type-I IFNs and are used to treat diseases, including hepatitis and multiple sclerosis. Emerging evidence suggests that type-I IFN receptors (IFNARs) are also expressed by microglia, astrocytes, and neurons in the central and peripheral nervous systems. Apart from canonical transcriptional regulations, IFN-α and IFN-β can rapidly suppress neuronal activity and synaptic transmission via non-genomic regulation, leading to potent analgesia. IFN-γ is the only member of the type-II IFN family and induces central sensitization and microglia activation in persistent pain. We discuss how type-I and type-II IFNs regulate pain and infection via neuro-immune modulations, with special focus on neuroinflammation and neuro-glial interactions. We also highlight distinct roles of type-I IFNs in the peripheral and central nervous system. Insights into IFN signaling in nociceptors and their distinct actions in physiological vs. pathological and acute vs. chronic conditions will improve our treatments of pain after surgeries, traumas, and infections.Ping-Heng TanJasmine JiJasmine JiChun-Chang YehRu-Rong JiRu-Rong JiRu-Rong JiFrontiers Media S.A.articleinfectionmicrogliaastrocytesIFN-αIFN-βIFN-γImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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infection microglia astrocytes IFN-α IFN-β IFN-γ Immunologic diseases. Allergy RC581-607 |
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infection microglia astrocytes IFN-α IFN-β IFN-γ Immunologic diseases. Allergy RC581-607 Ping-Heng Tan Jasmine Ji Jasmine Ji Chun-Chang Yeh Ru-Rong Ji Ru-Rong Ji Ru-Rong Ji Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions |
| description |
Interferons (IFNs) are cytokines that possess antiviral, antiproliferative, and immunomodulatory actions. IFN-α and IFN-β are two major family members of type-I IFNs and are used to treat diseases, including hepatitis and multiple sclerosis. Emerging evidence suggests that type-I IFN receptors (IFNARs) are also expressed by microglia, astrocytes, and neurons in the central and peripheral nervous systems. Apart from canonical transcriptional regulations, IFN-α and IFN-β can rapidly suppress neuronal activity and synaptic transmission via non-genomic regulation, leading to potent analgesia. IFN-γ is the only member of the type-II IFN family and induces central sensitization and microglia activation in persistent pain. We discuss how type-I and type-II IFNs regulate pain and infection via neuro-immune modulations, with special focus on neuroinflammation and neuro-glial interactions. We also highlight distinct roles of type-I IFNs in the peripheral and central nervous system. Insights into IFN signaling in nociceptors and their distinct actions in physiological vs. pathological and acute vs. chronic conditions will improve our treatments of pain after surgeries, traumas, and infections. |
| format |
article |
| author |
Ping-Heng Tan Jasmine Ji Jasmine Ji Chun-Chang Yeh Ru-Rong Ji Ru-Rong Ji Ru-Rong Ji |
| author_facet |
Ping-Heng Tan Jasmine Ji Jasmine Ji Chun-Chang Yeh Ru-Rong Ji Ru-Rong Ji Ru-Rong Ji |
| author_sort |
Ping-Heng Tan |
| title |
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions |
| title_short |
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions |
| title_full |
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions |
| title_fullStr |
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions |
| title_full_unstemmed |
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions |
| title_sort |
interferons in pain and infections: emerging roles in neuro-immune and neuro-glial interactions |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/cb603e0b63304077bd4b817fefca081e |
| work_keys_str_mv |
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