The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population

Objective. Determining sensitivity to allergens is an essential step in diagnosing children with allergic diseases. Chronic cough has remained poorly understood with causative triggers. The purpose of our study was to shed light on the relationship between sensitization to aeroallergens and chronic...

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Autores principales:	Myongsoon Sung, Dong Keon Yon, Seung Won Lee, Ju Hee Kim, Hey Sung Baek, Hye Mi Jee, Youn Ho Shin, Man Yong Han
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/cb61a8fe2e44479c8deeb264ef0d821c
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spelling	oai:doaj.org-article:cb61a8fe2e44479c8deeb264ef0d821c2021-11-29T00:56:59ZThe Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population2314-614110.1155/2021/5513611https://doaj.org/article/cb61a8fe2e44479c8deeb264ef0d821c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/5513611https://doaj.org/toc/2314-6141Objective. Determining sensitivity to allergens is an essential step in diagnosing children with allergic diseases. Chronic cough has remained poorly understood with causative triggers. The purpose of our study was to shed light on the relationship between sensitization to aeroallergens and chronic cough. Methods. This population-based study examined children (aged 7 years to 13 years) between June and July 2016. The 1,259 children, 72 of whom (5.7%) had a chronic cough, and 1,187 of whom (94.3%) did not (controls), completed the questionnaire, but 1,051 children completed skin prick tests (SPTs) with eight aeroallergens. Results. There were positive SPT results to at least 1 allergen in 549 children (52.2%). Sensitization to house dust mite (HDM) was most common (chronic cough=46.9%; controls=47.2%), followed by pollen (chronic cough=21.9%; controls=16.5%) in both groups, but there was no difference in allergic profile and sensitization to aeroallergen (P>0.05 for all comparisons). Multivariable analysis with adjustment for confounding indicated that children who were in sensitization to pollen had an increased risk of chronic cough (aOR=2.387; 95% CI: 1.115 to 5.111; P=0.025). Multivariable analysis with adjustment for confounding indicated that children who were exposed to current smoking (aOR=4.442; 95% CI: 1.831 to 10.776; P=0.001) and mold (aOR=1.988; 95% CI: 1.168 to 3.383; P=0.011) were associated with chronic cough. Conclusion. Sensitization to pollen should be considered as a potential contributing factor to the development of chronic cough in school-aged children.Myongsoon SungDong Keon YonSeung Won LeeJu Hee KimHey Sung BaekHye Mi JeeYoun Ho ShinMan Yong HanHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Myongsoon Sung Dong Keon Yon Seung Won Lee Ju Hee Kim Hey Sung Baek Hye Mi Jee Youn Ho Shin Man Yong Han The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population
description	Objective. Determining sensitivity to allergens is an essential step in diagnosing children with allergic diseases. Chronic cough has remained poorly understood with causative triggers. The purpose of our study was to shed light on the relationship between sensitization to aeroallergens and chronic cough. Methods. This population-based study examined children (aged 7 years to 13 years) between June and July 2016. The 1,259 children, 72 of whom (5.7%) had a chronic cough, and 1,187 of whom (94.3%) did not (controls), completed the questionnaire, but 1,051 children completed skin prick tests (SPTs) with eight aeroallergens. Results. There were positive SPT results to at least 1 allergen in 549 children (52.2%). Sensitization to house dust mite (HDM) was most common (chronic cough=46.9%; controls=47.2%), followed by pollen (chronic cough=21.9%; controls=16.5%) in both groups, but there was no difference in allergic profile and sensitization to aeroallergen (P>0.05 for all comparisons). Multivariable analysis with adjustment for confounding indicated that children who were in sensitization to pollen had an increased risk of chronic cough (aOR=2.387; 95% CI: 1.115 to 5.111; P=0.025). Multivariable analysis with adjustment for confounding indicated that children who were exposed to current smoking (aOR=4.442; 95% CI: 1.831 to 10.776; P=0.001) and mold (aOR=1.988; 95% CI: 1.168 to 3.383; P=0.011) were associated with chronic cough. Conclusion. Sensitization to pollen should be considered as a potential contributing factor to the development of chronic cough in school-aged children.
format	article
author	Myongsoon Sung Dong Keon Yon Seung Won Lee Ju Hee Kim Hey Sung Baek Hye Mi Jee Youn Ho Shin Man Yong Han
author_facet	Myongsoon Sung Dong Keon Yon Seung Won Lee Ju Hee Kim Hey Sung Baek Hye Mi Jee Youn Ho Shin Man Yong Han
author_sort	Myongsoon Sung
title	The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population
title_short	The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population
title_full	The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population
title_fullStr	The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population
title_full_unstemmed	The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population
title_sort	relationship between aeroallergen sensitization and chronic cough in school-aged children from general population
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/cb61a8fe2e44479c8deeb264ef0d821c
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The Relationship between Aeroallergen Sensitization and Chronic Cough in School-Aged Children from General Population

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