Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies

Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in the human bone marrow, in particular in a context of hematological malignancy, is more difficult to decipher by these s...

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Autores principales:	Stéphane J.C. Mancini, Karl Balabanian, Isabelle Corre, Julie Gavard, Gwendal Lazennec, Marie-Caroline Le Bousse-Kerdilès, Fawzia Louache, Véronique Maguer-Satta, Nathalie M. Mazure, Fatima Mechta-Grigoriou, Jean-François Peyron, Valérie Trichet, Olivier Herault
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microenvironment cancer-associated fibroblasts (CAFs) mesenchymal stem/stromal cells (MSCs) cytokines and chemokines energy/oxidative metabolism mitochondrial transfer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cb6393dbb52c4389b81b57399a686a9c
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spelling	oai:doaj.org-article:cb6393dbb52c4389b81b57399a686a9c2021-11-10T07:28:07ZDeciphering Tumor Niches: Lessons From Solid and Hematological Malignancies1664-322410.3389/fimmu.2021.766275https://doaj.org/article/cb6393dbb52c4389b81b57399a686a9c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.766275/fullhttps://doaj.org/toc/1664-3224Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in the human bone marrow, in particular in a context of hematological malignancy, is more difficult to decipher by these strategies and could benefit from the knowledge acquired on the niches of solid tumors. Indeed, some common features can be suspected, since the bone marrow is a frequent site of solid tumor metastases. Recent research on solid tumors has provided very interesting information on the interactions between tumoral cells and their microenvironment, composed notably of mesenchymal, endothelial and immune cells. This review thus focuses on recent discoveries on tumor niches that could help in understanding hematopoietic niches, with special attention to 4 particular points: i) the heterogeneity of carcinoma/cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs), ii) niche cytokines and chemokines, iii) the energy/oxidative metabolism and communication, especially mitochondrial transfer, and iv) the vascular niche through angiogenesis and endothelial plasticity. This review highlights actors and/or pathways of the microenvironment broadly involved in cancer processes. This opens avenues for innovative therapeutic opportunities targeting not only cancer stem cells but also their regulatory tumor niche(s), in order to improve current antitumor therapies.Stéphane J.C. ManciniStéphane J.C. ManciniStéphane J.C. ManciniKarl BalabanianKarl BalabanianKarl BalabanianIsabelle CorreIsabelle CorreIsabelle CorreJulie GavardJulie GavardJulie GavardJulie GavardGwendal LazennecGwendal LazennecMarie-Caroline Le Bousse-KerdilèsMarie-Caroline Le Bousse-KerdilèsFawzia LouacheFawzia LouacheVéronique Maguer-SattaVéronique Maguer-SattaNathalie M. MazureNathalie M. MazureFatima Mechta-GrigoriouFatima Mechta-GrigoriouJean-François PeyronJean-François PeyronValérie TrichetValérie TrichetValérie TrichetOlivier HeraultOlivier HeraultOlivier HeraultOlivier HeraultOlivier HeraultFrontiers Media S.A.articlemicroenvironmentcancer-associated fibroblasts (CAFs)mesenchymal stem/stromal cells (MSCs)cytokines and chemokinesenergy/oxidative metabolismmitochondrial transferImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microenvironment cancer-associated fibroblasts (CAFs) mesenchymal stem/stromal cells (MSCs) cytokines and chemokines energy/oxidative metabolism mitochondrial transfer Immunologic diseases. Allergy RC581-607
spellingShingle	microenvironment cancer-associated fibroblasts (CAFs) mesenchymal stem/stromal cells (MSCs) cytokines and chemokines energy/oxidative metabolism mitochondrial transfer Immunologic diseases. Allergy RC581-607 Stéphane J.C. Mancini Stéphane J.C. Mancini Stéphane J.C. Mancini Karl Balabanian Karl Balabanian Karl Balabanian Isabelle Corre Isabelle Corre Isabelle Corre Julie Gavard Julie Gavard Julie Gavard Julie Gavard Gwendal Lazennec Gwendal Lazennec Marie-Caroline Le Bousse-Kerdilès Marie-Caroline Le Bousse-Kerdilès Fawzia Louache Fawzia Louache Véronique Maguer-Satta Véronique Maguer-Satta Nathalie M. Mazure Nathalie M. Mazure Fatima Mechta-Grigoriou Fatima Mechta-Grigoriou Jean-François Peyron Jean-François Peyron Valérie Trichet Valérie Trichet Valérie Trichet Olivier Herault Olivier Herault Olivier Herault Olivier Herault Olivier Herault Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
description	Knowledge about the hematopoietic niche has evolved considerably in recent years, in particular through in vitro analyzes, mouse models and the use of xenografts. Its complexity in the human bone marrow, in particular in a context of hematological malignancy, is more difficult to decipher by these strategies and could benefit from the knowledge acquired on the niches of solid tumors. Indeed, some common features can be suspected, since the bone marrow is a frequent site of solid tumor metastases. Recent research on solid tumors has provided very interesting information on the interactions between tumoral cells and their microenvironment, composed notably of mesenchymal, endothelial and immune cells. This review thus focuses on recent discoveries on tumor niches that could help in understanding hematopoietic niches, with special attention to 4 particular points: i) the heterogeneity of carcinoma/cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs), ii) niche cytokines and chemokines, iii) the energy/oxidative metabolism and communication, especially mitochondrial transfer, and iv) the vascular niche through angiogenesis and endothelial plasticity. This review highlights actors and/or pathways of the microenvironment broadly involved in cancer processes. This opens avenues for innovative therapeutic opportunities targeting not only cancer stem cells but also their regulatory tumor niche(s), in order to improve current antitumor therapies.
format	article
author	Stéphane J.C. Mancini Stéphane J.C. Mancini Stéphane J.C. Mancini Karl Balabanian Karl Balabanian Karl Balabanian Isabelle Corre Isabelle Corre Isabelle Corre Julie Gavard Julie Gavard Julie Gavard Julie Gavard Gwendal Lazennec Gwendal Lazennec Marie-Caroline Le Bousse-Kerdilès Marie-Caroline Le Bousse-Kerdilès Fawzia Louache Fawzia Louache Véronique Maguer-Satta Véronique Maguer-Satta Nathalie M. Mazure Nathalie M. Mazure Fatima Mechta-Grigoriou Fatima Mechta-Grigoriou Jean-François Peyron Jean-François Peyron Valérie Trichet Valérie Trichet Valérie Trichet Olivier Herault Olivier Herault Olivier Herault Olivier Herault Olivier Herault
author_facet	Stéphane J.C. Mancini Stéphane J.C. Mancini Stéphane J.C. Mancini Karl Balabanian Karl Balabanian Karl Balabanian Isabelle Corre Isabelle Corre Isabelle Corre Julie Gavard Julie Gavard Julie Gavard Julie Gavard Gwendal Lazennec Gwendal Lazennec Marie-Caroline Le Bousse-Kerdilès Marie-Caroline Le Bousse-Kerdilès Fawzia Louache Fawzia Louache Véronique Maguer-Satta Véronique Maguer-Satta Nathalie M. Mazure Nathalie M. Mazure Fatima Mechta-Grigoriou Fatima Mechta-Grigoriou Jean-François Peyron Jean-François Peyron Valérie Trichet Valérie Trichet Valérie Trichet Olivier Herault Olivier Herault Olivier Herault Olivier Herault Olivier Herault
author_sort	Stéphane J.C. Mancini
title	Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
title_short	Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
title_full	Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
title_fullStr	Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
title_full_unstemmed	Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies
title_sort	deciphering tumor niches: lessons from solid and hematological malignancies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cb6393dbb52c4389b81b57399a686a9c
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Deciphering Tumor Niches: Lessons From Solid and Hematological Malignancies

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