An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster downstream of SCN5A and show that it controls the...

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Autores principales: Joyce C. K. Man, Rajiv A. Mohan, Malou van den Boogaard, Catharina R. E. Hilvering, Catherine Jenkins, Vincent Wakker, Valerio Bianchi, Wouter de Laat, Phil Barnett, Bastiaan J. Boukens, Vincent M. Christoffels
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/cb64f996f52046f4a1729c8c928335c9
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Sumario:Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster downstream of SCN5A and show that it controls the chromatin architecture of the locus and Scn5a expression.

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