An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster downstream of SCN5A and show that it controls the...

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Autores principales:	Joyce C. K. Man, Rajiv A. Mohan, Malou van den Boogaard, Catharina R. E. Hilvering, Catherine Jenkins, Vincent Wakker, Valerio Bianchi, Wouter de Laat, Phil Barnett, Bastiaan J. Boukens, Vincent M. Christoffels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb64f996f52046f4a1729c8c928335c9
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spelling	oai:doaj.org-article:cb64f996f52046f4a1729c8c928335c92021-12-02T17:02:07ZAn enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo10.1038/s41467-019-12856-52041-1723https://doaj.org/article/cb64f996f52046f4a1729c8c928335c92019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12856-5https://doaj.org/toc/2041-1723Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster downstream of SCN5A and show that it controls the chromatin architecture of the locus and Scn5a expression.Joyce C. K. ManRajiv A. MohanMalou van den BoogaardCatharina R. E. HilveringCatherine JenkinsVincent WakkerValerio BianchiWouter de LaatPhil BarnettBastiaan J. BoukensVincent M. ChristoffelsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joyce C. K. Man Rajiv A. Mohan Malou van den Boogaard Catharina R. E. Hilvering Catherine Jenkins Vincent Wakker Valerio Bianchi Wouter de Laat Phil Barnett Bastiaan J. Boukens Vincent M. Christoffels An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
description	Mutations associated with SCN5A, which encodes the major cardiac sodium channel, influence impulse conduction and are associated with arrhythmia disorders. Here, the authors identify an evolutionary conserved, super enhancer-like, regulatory cluster downstream of SCN5A and show that it controls the chromatin architecture of the locus and Scn5a expression.
format	article
author	Joyce C. K. Man Rajiv A. Mohan Malou van den Boogaard Catharina R. E. Hilvering Catherine Jenkins Vincent Wakker Valerio Bianchi Wouter de Laat Phil Barnett Bastiaan J. Boukens Vincent M. Christoffels
author_facet	Joyce C. K. Man Rajiv A. Mohan Malou van den Boogaard Catharina R. E. Hilvering Catherine Jenkins Vincent Wakker Valerio Bianchi Wouter de Laat Phil Barnett Bastiaan J. Boukens Vincent M. Christoffels
author_sort	Joyce C. K. Man
title	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
title_short	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
title_full	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
title_fullStr	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
title_full_unstemmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo
title_sort	enhancer cluster controls gene activity and topology of the scn5a-scn10a locus in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cb64f996f52046f4a1729c8c928335c9
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An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo

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