Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis

Abstract Abnormal thalamocortical networks involving specific thalamic nuclei have been implicated in schizophrenia pathophysiology. While comparable topography of anatomical and functional connectivity abnormalities has been reported in patients across illness stages, previous functional studies ha...

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Autores principales:	Yoo Bin Kwak, Kang Ik Kevin Cho, Wu Jeong Hwang, Ahra Kim, Minji Ha, Hyungyou Park, Junhee Lee, Tae Yong Lee, Minah Kim, Jun Soo Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb6972d2b8654ef49057254372807653
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spelling	oai:doaj.org-article:cb6972d2b8654ef490572543728076532021-12-02T19:16:18ZMapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis10.1038/s41598-021-99170-72045-2322https://doaj.org/article/cb6972d2b8654ef490572543728076532021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99170-7https://doaj.org/toc/2045-2322Abstract Abnormal thalamocortical networks involving specific thalamic nuclei have been implicated in schizophrenia pathophysiology. While comparable topography of anatomical and functional connectivity abnormalities has been reported in patients across illness stages, previous functional studies have been confined to anatomical pathways of thalamocortical networks. To address this issue, we incorporated large-scale brain network dynamics into examining thalamocortical functional connectivity. Forty patients with first-episode psychosis and forty healthy controls underwent T1-weighted and resting-state functional magnetic resonance imaging. Independent component analysis of voxelwise thalamic functional connectivity maps parcellated the cortex into thalamus-related networks, and thalamic subdivisions associated with these networks were delineated. Functional connectivity of (1) networks with the thalamus and (2) thalamic subdivision seeds were examined. In patients, functional connectivity of the salience network with the thalamus was decreased and localized to the ventrolateral (VL) and ventroposterior (VP) thalamus, while that of a network comprising the cerebellum, temporal and parietal regions was increased and localized to the mediodorsal (MD) thalamus. In patients, thalamic subdivision encompassing the VL and VP thalamus demonstrated hypoconnectivity and that encompassing the MD and pulvinar regions demonstrated hyperconnectivity. Our results extend the implications of disrupted thalamocortical networks involving specific thalamic nuclei to dysfunctional large-scale brain network dynamics in schizophrenia pathophysiology.Yoo Bin KwakKang Ik Kevin ChoWu Jeong HwangAhra KimMinji HaHyungyou ParkJunhee LeeTae Yong LeeMinah KimJun Soo KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoo Bin Kwak Kang Ik Kevin Cho Wu Jeong Hwang Ahra Kim Minji Ha Hyungyou Park Junhee Lee Tae Yong Lee Minah Kim Jun Soo Kwon Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
description	Abstract Abnormal thalamocortical networks involving specific thalamic nuclei have been implicated in schizophrenia pathophysiology. While comparable topography of anatomical and functional connectivity abnormalities has been reported in patients across illness stages, previous functional studies have been confined to anatomical pathways of thalamocortical networks. To address this issue, we incorporated large-scale brain network dynamics into examining thalamocortical functional connectivity. Forty patients with first-episode psychosis and forty healthy controls underwent T1-weighted and resting-state functional magnetic resonance imaging. Independent component analysis of voxelwise thalamic functional connectivity maps parcellated the cortex into thalamus-related networks, and thalamic subdivisions associated with these networks were delineated. Functional connectivity of (1) networks with the thalamus and (2) thalamic subdivision seeds were examined. In patients, functional connectivity of the salience network with the thalamus was decreased and localized to the ventrolateral (VL) and ventroposterior (VP) thalamus, while that of a network comprising the cerebellum, temporal and parietal regions was increased and localized to the mediodorsal (MD) thalamus. In patients, thalamic subdivision encompassing the VL and VP thalamus demonstrated hypoconnectivity and that encompassing the MD and pulvinar regions demonstrated hyperconnectivity. Our results extend the implications of disrupted thalamocortical networks involving specific thalamic nuclei to dysfunctional large-scale brain network dynamics in schizophrenia pathophysiology.
format	article
author	Yoo Bin Kwak Kang Ik Kevin Cho Wu Jeong Hwang Ahra Kim Minji Ha Hyungyou Park Junhee Lee Tae Yong Lee Minah Kim Jun Soo Kwon
author_facet	Yoo Bin Kwak Kang Ik Kevin Cho Wu Jeong Hwang Ahra Kim Minji Ha Hyungyou Park Junhee Lee Tae Yong Lee Minah Kim Jun Soo Kwon
author_sort	Yoo Bin Kwak
title	Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
title_short	Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
title_full	Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
title_fullStr	Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
title_full_unstemmed	Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
title_sort	mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb6972d2b8654ef49057254372807653
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Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis

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