Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation

Abstract Oral mucositis (OM) is one of the most frequent adverse events of high-dose conditioning chemotherapy with melphalan prior to autologous hematopoietic stem cell transplantation (AHSCT). It significantly reduces the patients’ quality of life. One of the preventive strategies for OM is cryoth...

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Autores principales:	Marcin Jasiński, Martyna Maciejewska, Anna Brodziak, Michał Górka, Kamila Skwierawska, Wiesław W. Jędrzejczak, Agnieszka Tomaszewska, Grzegorz W. Basak, Emilian Snarski
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Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb6d440c7d39446ba4cbf932b06f14ea
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spelling	oai:doaj.org-article:cb6d440c7d39446ba4cbf932b06f14ea2021-11-21T12:19:44ZIce-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation10.1038/s41598-021-02002-x2045-2322https://doaj.org/article/cb6d440c7d39446ba4cbf932b06f14ea2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02002-xhttps://doaj.org/toc/2045-2322Abstract Oral mucositis (OM) is one of the most frequent adverse events of high-dose conditioning chemotherapy with melphalan prior to autologous hematopoietic stem cell transplantation (AHSCT). It significantly reduces the patients’ quality of life. One of the preventive strategies for OM is cryotherapy. We retrospectively analyzed whether commercially available ice-cream could prevent OM during the melphalan infusion. We retrospectively analyzed 74 patients after AHSCT to see whether there is any correlation between OM and cryotherapy (ice-cream), melphalan dose (140 mg/m2 or 200 mg/m2). The incidence of OM in our study inversely correlated with cryotherapy in the form of ice-cream. Out of 74 patients receiving conditioning chemotherapy with high-dose melphalan, 52 received cryotherapy. Fifteen patients in the cryotherapy group (28.84%) developed OM, whereas 13 patients (59.09%) developed it in the group without cryotherapy. In a multiple linear regression test cryotherapy remained a significant protective factor against OM (p = 0.02) We have also seen the relationship between melphalan dose with OM (p < 0.005). Cryotherapy in the form of ice-cream is associated with a lower rate of OM and, therefore, could potentially be used as a cost-effective, less burdensome, and easy to implement method in prevention of oral mucositis.Marcin JasińskiMartyna MaciejewskaAnna BrodziakMichał GórkaKamila SkwierawskaWiesław W. JędrzejczakAgnieszka TomaszewskaGrzegorz W. BasakEmilian SnarskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcin Jasiński Martyna Maciejewska Anna Brodziak Michał Górka Kamila Skwierawska Wiesław W. Jędrzejczak Agnieszka Tomaszewska Grzegorz W. Basak Emilian Snarski Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
description	Abstract Oral mucositis (OM) is one of the most frequent adverse events of high-dose conditioning chemotherapy with melphalan prior to autologous hematopoietic stem cell transplantation (AHSCT). It significantly reduces the patients’ quality of life. One of the preventive strategies for OM is cryotherapy. We retrospectively analyzed whether commercially available ice-cream could prevent OM during the melphalan infusion. We retrospectively analyzed 74 patients after AHSCT to see whether there is any correlation between OM and cryotherapy (ice-cream), melphalan dose (140 mg/m2 or 200 mg/m2). The incidence of OM in our study inversely correlated with cryotherapy in the form of ice-cream. Out of 74 patients receiving conditioning chemotherapy with high-dose melphalan, 52 received cryotherapy. Fifteen patients in the cryotherapy group (28.84%) developed OM, whereas 13 patients (59.09%) developed it in the group without cryotherapy. In a multiple linear regression test cryotherapy remained a significant protective factor against OM (p = 0.02) We have also seen the relationship between melphalan dose with OM (p < 0.005). Cryotherapy in the form of ice-cream is associated with a lower rate of OM and, therefore, could potentially be used as a cost-effective, less burdensome, and easy to implement method in prevention of oral mucositis.
format	article
author	Marcin Jasiński Martyna Maciejewska Anna Brodziak Michał Górka Kamila Skwierawska Wiesław W. Jędrzejczak Agnieszka Tomaszewska Grzegorz W. Basak Emilian Snarski
author_facet	Marcin Jasiński Martyna Maciejewska Anna Brodziak Michał Górka Kamila Skwierawska Wiesław W. Jędrzejczak Agnieszka Tomaszewska Grzegorz W. Basak Emilian Snarski
author_sort	Marcin Jasiński
title	Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
title_short	Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
title_full	Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
title_fullStr	Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
title_full_unstemmed	Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
title_sort	ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cb6d440c7d39446ba4cbf932b06f14ea
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Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation

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