Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum

Plasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.

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Autores principales:	Qixin He, Shai Pilosof, Kathryn E. Tiedje, Shazia Ruybal-Pesántez, Yael Artzy-Randrup, Edward B. Baskerville, Karen P. Day, Mercedes Pascual
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb6f3ee99e554b4780c6cb642bf2ee64
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spelling	oai:doaj.org-article:cb6f3ee99e554b4780c6cb642bf2ee642021-12-02T15:33:37ZNetworks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum10.1038/s41467-018-04219-32041-1723https://doaj.org/article/cb6f3ee99e554b4780c6cb642bf2ee642018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04219-3https://doaj.org/toc/2041-1723Plasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.Qixin HeShai PilosofKathryn E. TiedjeShazia Ruybal-PesántezYael Artzy-RandrupEdward B. BaskervilleKaren P. DayMercedes PascualNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qixin He Shai Pilosof Kathryn E. Tiedje Shazia Ruybal-Pesántez Yael Artzy-Randrup Edward B. Baskerville Karen P. Day Mercedes Pascual Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
description	Plasmodium has evolved high genetic diversity in var genes, which encode for the major blood-stage antigen. Here, He et al. show how immune selection shapes the var gene repertoire in both simulated systems and a population in Ghana, by using neutral models and genetic similarity networks.
format	article
author	Qixin He Shai Pilosof Kathryn E. Tiedje Shazia Ruybal-Pesántez Yael Artzy-Randrup Edward B. Baskerville Karen P. Day Mercedes Pascual
author_facet	Qixin He Shai Pilosof Kathryn E. Tiedje Shazia Ruybal-Pesántez Yael Artzy-Randrup Edward B. Baskerville Karen P. Day Mercedes Pascual
author_sort	Qixin He
title	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_short	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_full	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_fullStr	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_full_unstemmed	Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum
title_sort	networks of genetic similarity reveal non-neutral processes shape strain structure in plasmodium falciparum
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cb6f3ee99e554b4780c6cb642bf2ee64
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Networks of genetic similarity reveal non-neutral processes shape strain structure in Plasmodium falciparum

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