Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature

This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid eliminat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shiqi Guo, Yanan Shi, Yanzi Liang, Lanze Liu, Kaoxiang Sun, Youxin Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nano-drug delivery system Hemocompatibility Adverse interaction Improvement strategy Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cb6f4db65e3644d4ade190b97a770d9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb6f4db65e3644d4ade190b97a770d9b
record_format	dspace
spelling	oai:doaj.org-article:cb6f4db65e3644d4ade190b97a770d9b2021-11-20T04:57:38ZRelationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature1818-087610.1016/j.ajps.2020.12.002https://doaj.org/article/cb6f4db65e3644d4ade190b97a770d9b2021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1818087621000118https://doaj.org/toc/1818-0876This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.Shiqi GuoYanan ShiYanzi LiangLanze LiuKaoxiang SunYouxin LiElsevierarticleNano-drug delivery systemHemocompatibilityAdverse interactionImprovement strategyTherapeutics. PharmacologyRM1-950ENAsian Journal of Pharmaceutical Sciences, Vol 16, Iss 5, Pp 551-576 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nano-drug delivery system Hemocompatibility Adverse interaction Improvement strategy Therapeutics. Pharmacology RM1-950
spellingShingle	Nano-drug delivery system Hemocompatibility Adverse interaction Improvement strategy Therapeutics. Pharmacology RM1-950 Shiqi Guo Yanan Shi Yanzi Liang Lanze Liu Kaoxiang Sun Youxin Li Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature
description	This article discusses the various blood interactions that may occur with various types of nano drug-loading systems. Nanoparticles enter the blood circulation as foreign objects. On the one hand, they may cause a series of inflammatory reactions and immune reactions, resulting in the rapid elimination of immune cells and the reticuloendothelial system, affecting their durability in the blood circulation. On the other hand, the premise of the drug-carrying system to play a therapeutic role depends on whether they cause coagulation and platelet activation, the absence of hemolysis and the elimination of immune cells. For different forms of nano drug-carrying systems, we can find the characteristics, elements and coping strategies of adverse blood reactions that we can find in previous researches. These adverse reactions may include destruction of blood cells, abnormal coagulation system, abnormal effects of plasma proteins, abnormal blood cell behavior, adverse immune and inflammatory reactions, and excessive vascular stimulation. In order to provide help for future research and formulation work on the blood compatibility of nano drug carriers.
format	article
author	Shiqi Guo Yanan Shi Yanzi Liang Lanze Liu Kaoxiang Sun Youxin Li
author_facet	Shiqi Guo Yanan Shi Yanzi Liang Lanze Liu Kaoxiang Sun Youxin Li
author_sort	Shiqi Guo
title	Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature
title_short	Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature
title_full	Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature
title_fullStr	Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature
title_full_unstemmed	Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature
title_sort	relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: what can we learn from the literature
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cb6f4db65e3644d4ade190b97a770d9b
work_keys_str_mv	AT shiqiguo relationshipandimprovementstrategiesbetweendrugnanocarriercharacteristicsandhemocompatibilitywhatcanwelearnfromtheliterature AT yananshi relationshipandimprovementstrategiesbetweendrugnanocarriercharacteristicsandhemocompatibilitywhatcanwelearnfromtheliterature AT yanziliang relationshipandimprovementstrategiesbetweendrugnanocarriercharacteristicsandhemocompatibilitywhatcanwelearnfromtheliterature AT lanzeliu relationshipandimprovementstrategiesbetweendrugnanocarriercharacteristicsandhemocompatibilitywhatcanwelearnfromtheliterature AT kaoxiangsun relationshipandimprovementstrategiesbetweendrugnanocarriercharacteristicsandhemocompatibilitywhatcanwelearnfromtheliterature AT youxinli relationshipandimprovementstrategiesbetweendrugnanocarriercharacteristicsandhemocompatibilitywhatcanwelearnfromtheliterature
_version_	1718419740533194752

Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: What can we learn from the literature

Ejemplares similares