Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk
Genetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression. Mice with epidermis-specific loss of Kif3a show disrupted skin barrier homeostasis and increased AD susceptibility.
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Nature Portfolio
2020
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oai:doaj.org-article:cb73b4e6acf04165bd138a7fc4b88cd62021-12-02T18:50:44ZDisease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk10.1038/s41467-020-17895-x2041-1723https://doaj.org/article/cb73b4e6acf04165bd138a7fc4b88cd62020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17895-xhttps://doaj.org/toc/2041-1723Genetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression. Mice with epidermis-specific loss of Kif3a show disrupted skin barrier homeostasis and increased AD susceptibility.Mariana L. StevensZhonghua ZhangElisabet JohanssonSamriddha RayAmrita JagpalBrandy P. RuffArjun KothariHua HeLisa J. MartinHong JiKathryn Wikenheiser-BrokampMatthew T. WeirauchDorothy M. SuppJocelyn M. Biagini MyersGurjit K. Khurana HersheyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mariana L. Stevens Zhonghua Zhang Elisabet Johansson Samriddha Ray Amrita Jagpal Brandy P. Ruff Arjun Kothari Hua He Lisa J. Martin Hong Ji Kathryn Wikenheiser-Brokamp Matthew T. Weirauch Dorothy M. Supp Jocelyn M. Biagini Myers Gurjit K. Khurana Hershey Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| description |
Genetic variants in KIF3A are associated with atopic dermatitis (AD). Here, the authors identify two AD-risk alleles that show high methylation resulting in lower KIF3A expression. Mice with epidermis-specific loss of Kif3a show disrupted skin barrier homeostasis and increased AD susceptibility. |
| format |
article |
| author |
Mariana L. Stevens Zhonghua Zhang Elisabet Johansson Samriddha Ray Amrita Jagpal Brandy P. Ruff Arjun Kothari Hua He Lisa J. Martin Hong Ji Kathryn Wikenheiser-Brokamp Matthew T. Weirauch Dorothy M. Supp Jocelyn M. Biagini Myers Gurjit K. Khurana Hershey |
| author_facet |
Mariana L. Stevens Zhonghua Zhang Elisabet Johansson Samriddha Ray Amrita Jagpal Brandy P. Ruff Arjun Kothari Hua He Lisa J. Martin Hong Ji Kathryn Wikenheiser-Brokamp Matthew T. Weirauch Dorothy M. Supp Jocelyn M. Biagini Myers Gurjit K. Khurana Hershey |
| author_sort |
Mariana L. Stevens |
| title |
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| title_short |
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| title_full |
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| title_fullStr |
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| title_full_unstemmed |
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| title_sort |
disease-associated kif3a variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/cb73b4e6acf04165bd138a7fc4b88cd6 |
| work_keys_str_mv |
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| _version_ |
1718377532334538752 |