Tight Junctions of the Neurovascular Unit

The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight jun...

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Autores principales:	Natalie Hudson, Matthew Campbell
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tight junction neurovasculature endothelial cells blood brain barrier inner blood-retinal barrier Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/cb749eae65cd4941967020af42c4dedd
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spelling	oai:doaj.org-article:cb749eae65cd4941967020af42c4dedd2021-11-19T05:47:13ZTight Junctions of the Neurovascular Unit1662-509910.3389/fnmol.2021.752781https://doaj.org/article/cb749eae65cd4941967020af42c4dedd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.752781/fullhttps://doaj.org/toc/1662-5099The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathology.Natalie HudsonMatthew CampbellFrontiers Media S.A.articletight junctionneurovasculatureendothelial cellsblood brain barrierinner blood-retinal barrierNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tight junction neurovasculature endothelial cells blood brain barrier inner blood-retinal barrier Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	tight junction neurovasculature endothelial cells blood brain barrier inner blood-retinal barrier Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Natalie Hudson Matthew Campbell Tight Junctions of the Neurovascular Unit
description	The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the lining of these blood vessels are interconnected by the presence of tight junctions which form the BBB and iBRB. These tight junctions, formed of numerous interacting proteins, enable the entry of molecules into neural tissues while restricting the entry of harmful material such as anaphylatoxins, bacteria and viruses. If the tight junction complex becomes dysregulated due to changes in expression levels of one or more of the components, this can have detrimental effects leading to brain and retinal pathology.
format	article
author	Natalie Hudson Matthew Campbell
author_facet	Natalie Hudson Matthew Campbell
author_sort	Natalie Hudson
title	Tight Junctions of the Neurovascular Unit
title_short	Tight Junctions of the Neurovascular Unit
title_full	Tight Junctions of the Neurovascular Unit
title_fullStr	Tight Junctions of the Neurovascular Unit
title_full_unstemmed	Tight Junctions of the Neurovascular Unit
title_sort	tight junctions of the neurovascular unit
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cb749eae65cd4941967020af42c4dedd
work_keys_str_mv	AT nataliehudson tightjunctionsoftheneurovascularunit AT matthewcampbell tightjunctionsoftheneurovascularunit
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Tight Junctions of the Neurovascular Unit

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