Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus

Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irina Arkad'evna Bondar', Vadim Valer'evich Klimontov, Ekaterina Mikhailovna Parfent'eva, Vyacheslav Vital'evich Romanov, Alexander Petrovich Nadeev
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	type 1 diabetes mellitus diabetic nephropathy type iv collagen Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/cb78caa72c344a66a7dcc87ed9e7dbc5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb78caa72c344a66a7dcc87ed9e7dbc5
record_format	dspace
spelling	oai:doaj.org-article:cb78caa72c344a66a7dcc87ed9e7dbc52021-11-14T09:00:16ZUrinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus2072-03512072-037810.14341/2072-0351-5813https://doaj.org/article/cb78caa72c344a66a7dcc87ed9e7dbc52011-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5813https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with macroalbuminuria) by an enzyme immunoassay. 10 healthy individuals were acted as the control group. Renal biopsy was performedin 22 patients. Deposits of type IV collagen were revealed by 11 individuals by immunohistochemistry. Results. The urinary excretion of type IV collagen increased with severety of diabetic nephropathy, correlating with the urinary albumin/creatinineratio, serum creatinine and parameters of daytime and nighttime systolic and diastolic blood pressure. Patients with excessive accumulation of typeIV collagen in the glomeruli had significantly higher level of type IV collagen in the urine. Conclusion. The determination of urinary type IV collagen can be used for early detection of renal fibrosis in patients with type 1 diabetes.Irina Arkad'evna Bondar'Vadim Valer'evich KlimontovEkaterina Mikhailovna Parfent'evaVyacheslav Vital'evich RomanovAlexander Petrovich NadeevEndocrinology Research Centrearticletype 1 diabetes mellitusdiabetic nephropathytype iv collagenNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 4, Pp 29-31 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 1 diabetes mellitus diabetic nephropathy type iv collagen Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 1 diabetes mellitus diabetic nephropathy type iv collagen Nutritional diseases. Deficiency diseases RC620-627 Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov Ekaterina Mikhailovna Parfent'eva Vyacheslav Vital'evich Romanov Alexander Petrovich Nadeev Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
description	Aim. To determine the diagnostic value of urinary excretion of type IV collagen in patients with type 1 diabetes with different stages of nephropathy.Methods. Urinary type IV collagen was determined in 60 patients with type 1 diabetes (23 with normal albuminuria, 28 with microalbuminuriaand 9 with macroalbuminuria) by an enzyme immunoassay. 10 healthy individuals were acted as the control group. Renal biopsy was performedin 22 patients. Deposits of type IV collagen were revealed by 11 individuals by immunohistochemistry. Results. The urinary excretion of type IV collagen increased with severety of diabetic nephropathy, correlating with the urinary albumin/creatinineratio, serum creatinine and parameters of daytime and nighttime systolic and diastolic blood pressure. Patients with excessive accumulation of typeIV collagen in the glomeruli had significantly higher level of type IV collagen in the urine. Conclusion. The determination of urinary type IV collagen can be used for early detection of renal fibrosis in patients with type 1 diabetes.
format	article
author	Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov Ekaterina Mikhailovna Parfent'eva Vyacheslav Vital'evich Romanov Alexander Petrovich Nadeev
author_facet	Irina Arkad'evna Bondar' Vadim Valer'evich Klimontov Ekaterina Mikhailovna Parfent'eva Vyacheslav Vital'evich Romanov Alexander Petrovich Nadeev
author_sort	Irina Arkad'evna Bondar'
title	Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
title_short	Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
title_full	Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
title_fullStr	Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
title_full_unstemmed	Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus
title_sort	urinary excretion of type iv collagen as an early marker of renal fibrosis in patients with diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/cb78caa72c344a66a7dcc87ed9e7dbc5
work_keys_str_mv	AT irinaarkadevnabondar urinaryexcretionoftypeivcollagenasanearlymarkerofrenalfibrosisinpatientswithdiabetesmellitus AT vadimvalerevichklimontov urinaryexcretionoftypeivcollagenasanearlymarkerofrenalfibrosisinpatientswithdiabetesmellitus AT ekaterinamikhailovnaparfenteva urinaryexcretionoftypeivcollagenasanearlymarkerofrenalfibrosisinpatientswithdiabetesmellitus AT vyacheslavvitalevichromanov urinaryexcretionoftypeivcollagenasanearlymarkerofrenalfibrosisinpatientswithdiabetesmellitus AT alexanderpetrovichnadeev urinaryexcretionoftypeivcollagenasanearlymarkerofrenalfibrosisinpatientswithdiabetesmellitus
_version_	1718429614039105536

Urinary excretion of type IV collagen as an early marker of renal fibrosis in patients with diabetes mellitus

Ejemplares similares