Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits

Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustiv...

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Autores principales:	Amélia M. Silva, Luís M. Félix, Isabel Teixeira, Carlos Martins-Gomes, Judith Schäfer, Eliana B. Souto, Dario J. Santos, Mirko Bunzel, Fernando M. Nunes
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Orange thyme Phenolic composition Antioxidant activity Anti-proliferative Anti-inflammatory activity Aqueous extract Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456
Acceso en línea:	https://doaj.org/article/cb7a29467b5341c186e1e0552ce53ddd
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spelling	oai:doaj.org-article:cb7a29467b5341c186e1e0552ce53ddd2021-11-30T05:05:49ZOrange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits2590-157510.1016/j.fochx.2021.100171https://doaj.org/article/cb7a29467b5341c186e1e0552ce53ddd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590157521000596https://doaj.org/toc/2590-1575Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.Amélia M. SilvaLuís M. FélixIsabel TeixeiraCarlos Martins-GomesJudith SchäferEliana B. SoutoDario J. SantosMirko BunzelFernando M. NunesElsevierarticleOrange thymePhenolic compositionAntioxidant activityAnti-proliferativeAnti-inflammatory activityAqueous extractNutrition. Foods and food supplyTX341-641Food processing and manufactureTP368-456ENFood Chemistry: X, Vol 12, Iss , Pp 100171- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Orange thyme Phenolic composition Antioxidant activity Anti-proliferative Anti-inflammatory activity Aqueous extract Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456
spellingShingle	Orange thyme Phenolic composition Antioxidant activity Anti-proliferative Anti-inflammatory activity Aqueous extract Nutrition. Foods and food supply TX341-641 Food processing and manufacture TP368-456 Amélia M. Silva Luís M. Félix Isabel Teixeira Carlos Martins-Gomes Judith Schäfer Eliana B. Souto Dario J. Santos Mirko Bunzel Fernando M. Nunes Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
description	Orange thyme (Thymus fragrantissimus) is becoming widely used in food as a condiment and herbal tea, nevertheless its chemical composition and potential bioactivities are largely unknown. Thus the objective of this work is to obtain a detailed phytochemical profile of T. fragrantissimus by exhaustive ethanolic extraction and by aqueous decoction mimicking its consumption. Extracts showed high content in rosmarinic acid, luteolin-O-hexuronide and eriodictyol-O-hexuronide; these were the main phenolic compounds present in orange thyme accounting for 85% of the total phenolic compounds. Orange thyme extracts presented high scavenging activity against nitric oxide and superoxide radicals. Both extracts presented significant inhibitory effect of tyrosinase activity and moderate anti-acetylcholinesterase activity. Both extracts showed a good in vitro anti-inflammatory activity and a weak anti-proliferative/cytotoxic activity against Caco-2 and HepG2 cell lines supporting its safe use. Orange thyme is a very good source of bioactive compounds with potential use in different food and nutraceutical industries.
format	article
author	Amélia M. Silva Luís M. Félix Isabel Teixeira Carlos Martins-Gomes Judith Schäfer Eliana B. Souto Dario J. Santos Mirko Bunzel Fernando M. Nunes
author_facet	Amélia M. Silva Luís M. Félix Isabel Teixeira Carlos Martins-Gomes Judith Schäfer Eliana B. Souto Dario J. Santos Mirko Bunzel Fernando M. Nunes
author_sort	Amélia M. Silva
title	Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_short	Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_full	Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_fullStr	Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_full_unstemmed	Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
title_sort	orange thyme: phytochemical profiling, in vitro bioactivities of extracts and potential health benefits
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cb7a29467b5341c186e1e0552ce53ddd
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Orange thyme: Phytochemical profiling, in vitro bioactivities of extracts and potential health benefits

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