Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)
Abstract USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the subgroup that has aberrant TAL1 oncogene activation. Network analysis of > 2...
Guardado en:
Autores principales: | Timothy I. Shaw, Li Dong, Liqing Tian, Chenxi Qian, Yu Liu, Bensheng Ju, Anthony High, Kanisha Kavdia, Vishwajeeth R. Pagala, Bridget Shaner, Deqing Pei, John Easton, Laura J. Janke, Shaina N. Porter, Xiaotu Ma, Cheng Cheng, Shondra M. Pruett-Miller, John Choi, Jiyang Yu, Junmin Peng, Wei Gu, A. Thomas Look, James R. Downing, Jinghui Zhang |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/cb7c285f227c42abb04cd250bb2d752a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Exercise does not protect against MPTP-induced neurotoxicity in BDNF haploinsufficient mice.
por: Kim M Gerecke, et al.
Publicado: (2012) -
Notch1 haploinsufficiency in mice accelerates adipogenesis
por: Kazutoshi Yamaguchi, et al.
Publicado: (2021) -
A20 Haploinsufficiency in East Asia
por: Tomonori Kadowaki, et al.
Publicado: (2021) -
Rebalancing gene haploinsufficiency in vivo by targeting chromatin
por: Filomena Gabriella Fulcoli, et al.
Publicado: (2016) -
Haploinsufficiency of akt1 prolongs the lifespan of mice.
por: Aika Nojima, et al.
Publicado: (2013)