Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography
Zeynep Kayaarasi Öztürker, Kadir Eltutar, Belma Karini, Sezin Özdogan Erkul, Özen Ayrancı Osmanbaşoğlu, Pınar Sultan Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey Purpose: To compare optic nerve head parameters, the thicknes...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2016
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/cb7ccfebb14544bbb8c927f544682d3c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:cb7ccfebb14544bbb8c927f544682d3c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:cb7ccfebb14544bbb8c927f544682d3c2021-12-02T00:20:08ZOptic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography1177-5483https://doaj.org/article/cb7ccfebb14544bbb8c927f544682d3c2016-09-01T00:00:00Zhttps://www.dovepress.com/optic-nerve-head-topography-and-retinal-structural-changes-in-eyes-wit-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Zeynep Kayaarasi Öztürker, Kadir Eltutar, Belma Karini, Sezin Özdogan Erkul, Özen Ayrancı Osmanbaşoğlu, Pınar Sultan Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey Purpose: To compare optic nerve head parameters, the thicknesses of the peripapillary retinal nerve fiber layer (pRNFL), the macular retinal nerve fiber layer (mRNFL), the ganglion cell complex (GCC), and the ganglion cell–inner plexiform layer (GCIPL) in macrodisks and normal-sized healthy disks using spectral domain optical coherence tomography. Patients and methods: A total of 88 healthy eyes (42 macrodisks and 46 normal-sized disks) were prospectively enrolled in the study. Optic nerve head parameters as well as pRNFL, mRNFL, GCC, and GCIPL thicknesses were measured in all subjects. Optic disk areas (ODAs) >2.70 mm2 were defined as macrodisks. All spectral domain optical coherence tomography parameters were compared between normal-sized disks and macrodisks. Results: The mean age of the participants was 49.4±5.7 years in the normal size group and 51.55±6.3 years in the macrodisk group (P=0.65). The average ODAs were 2.23±0.29 mm2 and 3.30±0.59 mm2 in the normal size and the macrodisk groups, respectively. ODA (P<0.001), cup area (P<0.001), cup disk area ratio (P<0.001), horizontal cup disk ratio (P<0.001), vertical cup disk ratio (P<0.001), horizontal disk diameter (P<0.001), vertical disk diameter (P<0.001), and cup volume (P<0.001) were significantly higher in the macrodisk group. The inferior mRNFL thickness was significantly lower (P=0.042), and the GCC inferior and GCIPL inferior thicknesses were found to be lower with low significance (P=0.052, P=0.059, respectively) in the macrodisk group. Rim volume (P=0.622), total pRNFL (P=0.201), superior pRNFL (P=0.123), inferior pRNFL (P=0.168), average macular thickness (P=0.162), total mRNFL (P=0.171), superior mRNFL (P=0.356), total GCC (P=0.080), superior GCC (P=0.261), total GCIPL (P=0.214), and superior GCIPL (P=0.515) thicknesses were similar in both groups. Conclusion: Optic disk topography and retinal structures show different characteristics in healthy eyes with macrodisks. These disk size-dependent variations suggest that large optic disks may be more susceptible to glaucomatous damage. Keywords: macrodisk, optic nerve head, nerve fiber layer, ganglion cell complexOzturker ZKEltutar KKarini BErkul SOOsmanbasoglu OASultan PDove Medical PressarticleMacrodiscoptic nerve headretinal nerve fiber layerganglion cell complexOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1737-1742 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Macrodisc optic nerve head retinal nerve fiber layer ganglion cell complex Ophthalmology RE1-994 |
| spellingShingle |
Macrodisc optic nerve head retinal nerve fiber layer ganglion cell complex Ophthalmology RE1-994 Ozturker ZK Eltutar K Karini B Erkul SO Osmanbasoglu OA Sultan P Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| description |
Zeynep Kayaarasi Öztürker, Kadir Eltutar, Belma Karini, Sezin Özdogan Erkul, Özen Ayrancı Osmanbaşoğlu, Pınar Sultan Ophthalmology Department, Istanbul Research and Training Hospital, Istanbul, Turkey Purpose: To compare optic nerve head parameters, the thicknesses of the peripapillary retinal nerve fiber layer (pRNFL), the macular retinal nerve fiber layer (mRNFL), the ganglion cell complex (GCC), and the ganglion cell–inner plexiform layer (GCIPL) in macrodisks and normal-sized healthy disks using spectral domain optical coherence tomography. Patients and methods: A total of 88 healthy eyes (42 macrodisks and 46 normal-sized disks) were prospectively enrolled in the study. Optic nerve head parameters as well as pRNFL, mRNFL, GCC, and GCIPL thicknesses were measured in all subjects. Optic disk areas (ODAs) >2.70 mm2 were defined as macrodisks. All spectral domain optical coherence tomography parameters were compared between normal-sized disks and macrodisks. Results: The mean age of the participants was 49.4±5.7 years in the normal size group and 51.55±6.3 years in the macrodisk group (P=0.65). The average ODAs were 2.23±0.29 mm2 and 3.30±0.59 mm2 in the normal size and the macrodisk groups, respectively. ODA (P<0.001), cup area (P<0.001), cup disk area ratio (P<0.001), horizontal cup disk ratio (P<0.001), vertical cup disk ratio (P<0.001), horizontal disk diameter (P<0.001), vertical disk diameter (P<0.001), and cup volume (P<0.001) were significantly higher in the macrodisk group. The inferior mRNFL thickness was significantly lower (P=0.042), and the GCC inferior and GCIPL inferior thicknesses were found to be lower with low significance (P=0.052, P=0.059, respectively) in the macrodisk group. Rim volume (P=0.622), total pRNFL (P=0.201), superior pRNFL (P=0.123), inferior pRNFL (P=0.168), average macular thickness (P=0.162), total mRNFL (P=0.171), superior mRNFL (P=0.356), total GCC (P=0.080), superior GCC (P=0.261), total GCIPL (P=0.214), and superior GCIPL (P=0.515) thicknesses were similar in both groups. Conclusion: Optic disk topography and retinal structures show different characteristics in healthy eyes with macrodisks. These disk size-dependent variations suggest that large optic disks may be more susceptible to glaucomatous damage. Keywords: macrodisk, optic nerve head, nerve fiber layer, ganglion cell complex |
| format |
article |
| author |
Ozturker ZK Eltutar K Karini B Erkul SO Osmanbasoglu OA Sultan P |
| author_facet |
Ozturker ZK Eltutar K Karini B Erkul SO Osmanbasoglu OA Sultan P |
| author_sort |
Ozturker ZK |
| title |
Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| title_short |
Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| title_full |
Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| title_fullStr |
Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| title_full_unstemmed |
Optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| title_sort |
optic nerve head topography and retinal structural changes in eyes with macrodisks: a comparative study with spectral domain optical coherence tomography |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/cb7ccfebb14544bbb8c927f544682d3c |
| work_keys_str_mv |
AT ozturkerzk opticnerveheadtopographyandretinalstructuralchangesineyeswithmacrodisksacomparativestudywithspectraldomainopticalcoherencetomography AT eltutark opticnerveheadtopographyandretinalstructuralchangesineyeswithmacrodisksacomparativestudywithspectraldomainopticalcoherencetomography AT karinib opticnerveheadtopographyandretinalstructuralchangesineyeswithmacrodisksacomparativestudywithspectraldomainopticalcoherencetomography AT erkulso opticnerveheadtopographyandretinalstructuralchangesineyeswithmacrodisksacomparativestudywithspectraldomainopticalcoherencetomography AT osmanbasogluoa opticnerveheadtopographyandretinalstructuralchangesineyeswithmacrodisksacomparativestudywithspectraldomainopticalcoherencetomography AT sultanp opticnerveheadtopographyandretinalstructuralchangesineyeswithmacrodisksacomparativestudywithspectraldomainopticalcoherencetomography |
| _version_ |
1718403828002324480 |