Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

Feng Li,1 Yan Chen,1,2 Shubo Liu,1 Jian Qi,1 Weiying Wang,1 Chenhua Wang,1 Ruiyue Zhong,1 Zhijun Chen,1 Xiaoming Li,1 Yuanzhou Guan,1 Wei Kong,1,2 Yong Zhang1,2 1National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 2Key Laboratory for Molecular Enz...

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Autores principales:	Li F, Chen Y, Liu SB, Qi J, Wang WY, Wang CH, Zhong RY, Chen ZJ, Li XM, Guan YZ, Kong W, Zhang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	zein phase separation microparticle nanoparticle encapsulation drug release Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cb7e9b766a5144328c5f94e901d7d495
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spelling	oai:doaj.org-article:cb7e9b766a5144328c5f94e901d7d4952021-12-02T08:11:16ZSize-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate1178-2013https://doaj.org/article/cb7e9b766a5144328c5f94e901d7d4952017-11-01T00:00:00Zhttps://www.dovepress.com/size-controlled-fabrication-of-zein-nanomicroparticles-by-modified-ant-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Feng Li,1 Yan Chen,1,2 Shubo Liu,1 Jian Qi,1 Weiying Wang,1 Chenhua Wang,1 Ruiyue Zhong,1 Zhijun Chen,1 Xiaoming Li,1 Yuanzhou Guan,1 Wei Kong,1,2 Yong Zhang1,2 1National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 2Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China Abstract: Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, the fabrication of size-controlled zein particles has been a challenging issue. In this study, a modified anti-solvent precipitation method was developed, and the effects of various factors, such as mixing method, solvent/anti-solvent ratio, temperature, zein concentrations and the presence of sodium caseinate (SC) on properties of zein particles were investigated. Evidence is presented that, among the previously mentioned factors, the mixing method, especially mixing rate, could be used as an effective parameter to control the size of zein particles without changing other parameters. Moreover, through fine-tuning the mixing rate together with zein concentration, particles with sizes ranging from nanometers to micrometers and low polydispersity index values could be easily obtained. Based on the size-controlled fabrication method, SC-coated zein nanoparticles could also be obtained in a size-controlled manner by incubation of the coating material with the already-formed zein particles. The resultant nanoparticles showed better performance in both drug loading and controlled release, compared with zein/SC hybrid nanoparticles fabricated by adding aqueous ethanol solution to SC solution. The possible mechanisms of the nanoprecipitation process and self-assembly formation of these nanoparticles are discussed. Keywords: zein, phase separation, microparticle, nanoparticle, encapsulation, drug release Li FChen YLiu SBQi JWang WYWang CHZhong RYChen ZJLi XMGuan YZKong WZhang YDove Medical Pressarticlezeinphase separationmicroparticlenanoparticleencapsulationdrug releaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 8197-8209 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	zein phase separation microparticle nanoparticle encapsulation drug release Medicine (General) R5-920
spellingShingle	zein phase separation microparticle nanoparticle encapsulation drug release Medicine (General) R5-920 Li F Chen Y Liu SB Qi J Wang WY Wang CH Zhong RY Chen ZJ Li XM Guan YZ Kong W Zhang Y Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
description	Feng Li,1 Yan Chen,1,2 Shubo Liu,1 Jian Qi,1 Weiying Wang,1 Chenhua Wang,1 Ruiyue Zhong,1 Zhijun Chen,1 Xiaoming Li,1 Yuanzhou Guan,1 Wei Kong,1,2 Yong Zhang1,2 1National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 2Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China Abstract: Zein-based nano/microparticles have been demonstrated to be promising carrier systems for both the food industry and biomedical applications. However, the fabrication of size-controlled zein particles has been a challenging issue. In this study, a modified anti-solvent precipitation method was developed, and the effects of various factors, such as mixing method, solvent/anti-solvent ratio, temperature, zein concentrations and the presence of sodium caseinate (SC) on properties of zein particles were investigated. Evidence is presented that, among the previously mentioned factors, the mixing method, especially mixing rate, could be used as an effective parameter to control the size of zein particles without changing other parameters. Moreover, through fine-tuning the mixing rate together with zein concentration, particles with sizes ranging from nanometers to micrometers and low polydispersity index values could be easily obtained. Based on the size-controlled fabrication method, SC-coated zein nanoparticles could also be obtained in a size-controlled manner by incubation of the coating material with the already-formed zein particles. The resultant nanoparticles showed better performance in both drug loading and controlled release, compared with zein/SC hybrid nanoparticles fabricated by adding aqueous ethanol solution to SC solution. The possible mechanisms of the nanoprecipitation process and self-assembly formation of these nanoparticles are discussed. Keywords: zein, phase separation, microparticle, nanoparticle, encapsulation, drug release
format	article
author	Li F Chen Y Liu SB Qi J Wang WY Wang CH Zhong RY Chen ZJ Li XM Guan YZ Kong W Zhang Y
author_facet	Li F Chen Y Liu SB Qi J Wang WY Wang CH Zhong RY Chen ZJ Li XM Guan YZ Kong W Zhang Y
author_sort	Li F
title	Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
title_short	Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
title_full	Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
title_fullStr	Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
title_full_unstemmed	Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
title_sort	size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/cb7e9b766a5144328c5f94e901d7d495
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Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate

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