The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

Summary: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed acute MIS-C patients had highly activated neutrophils, classical monocytes a...

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Autores principales:	Eleni Syrimi, Eanna Fennell, Alex Richter, Pavle Vrljicak, Richard Stark, Sascha Ott, Paul G. Murray, Eslam Al-Abadi, Ashish Chikermane, Pamela Dawson, Scott Hackett, Deepthi Jyothish, Hari Krishnan Kanthimathinathan, Sean Monaghan, Prasad Nagakumar, Barnaby R. Scholefield, Steven Welch, Naeem Khan, Sian Faustini, Kate Davies, Wioleta M. Zelek, Pamela Kearns, Graham S. Taylor
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Genomics Immune response Immune system disorder Immunology Science Q
Acceso en línea:	https://doaj.org/article/cb7ebce799514eb180b30ec967fb855b
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spelling	oai:doaj.org-article:cb7ebce799514eb180b30ec967fb855b2021-11-20T05:08:21ZThe immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery2589-004210.1016/j.isci.2021.103215https://doaj.org/article/cb7ebce799514eb180b30ec967fb855b2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221011834https://doaj.org/toc/2589-0042Summary: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed acute MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells, with increased frequencies of B-cell plasmablasts and double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated immune features including increased monocyte CD163 levels, emergence of a new population of immature neutrophils and, in some patients, transiently increased plasma arginase. Plasma profiling identified multiple features shared by MIS-C, Kawasaki Disease and COVID-19 and that therapeutic inhibition of IL-6 may be preferable to IL-1 or TNF-α. We identified several potential mechanisms of action for IVIG, the most commonly used drug to treat MIS-C. Finally, we showed systemic complement activation with high plasma C5b-9 levels is common in MIS-C suggesting complement inhibitors could be used to treat the disease.Eleni SyrimiEanna FennellAlex RichterPavle VrljicakRichard StarkSascha OttPaul G. MurrayEslam Al-AbadiAshish ChikermanePamela DawsonScott HackettDeepthi JyothishHari Krishnan KanthimathinathanSean MonaghanPrasad NagakumarBarnaby R. ScholefieldSteven WelchNaeem KhanSian FaustiniKate DaviesWioleta M. ZelekPamela KearnsGraham S. TaylorElsevierarticleGenomicsImmune responseImmune system disorderImmunologyScienceQENiScience, Vol 24, Iss 11, Pp 103215- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genomics Immune response Immune system disorder Immunology Science Q
spellingShingle	Genomics Immune response Immune system disorder Immunology Science Q Eleni Syrimi Eanna Fennell Alex Richter Pavle Vrljicak Richard Stark Sascha Ott Paul G. Murray Eslam Al-Abadi Ashish Chikermane Pamela Dawson Scott Hackett Deepthi Jyothish Hari Krishnan Kanthimathinathan Sean Monaghan Prasad Nagakumar Barnaby R. Scholefield Steven Welch Naeem Khan Sian Faustini Kate Davies Wioleta M. Zelek Pamela Kearns Graham S. Taylor The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
description	Summary: Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Deep immune profiling showed acute MIS-C patients had highly activated neutrophils, classical monocytes and memory CD8+ T-cells, with increased frequencies of B-cell plasmablasts and double-negative B-cells. Post treatment samples from the same patients, taken during symptom resolution, identified recovery-associated immune features including increased monocyte CD163 levels, emergence of a new population of immature neutrophils and, in some patients, transiently increased plasma arginase. Plasma profiling identified multiple features shared by MIS-C, Kawasaki Disease and COVID-19 and that therapeutic inhibition of IL-6 may be preferable to IL-1 or TNF-α. We identified several potential mechanisms of action for IVIG, the most commonly used drug to treat MIS-C. Finally, we showed systemic complement activation with high plasma C5b-9 levels is common in MIS-C suggesting complement inhibitors could be used to treat the disease.
format	article
author	Eleni Syrimi Eanna Fennell Alex Richter Pavle Vrljicak Richard Stark Sascha Ott Paul G. Murray Eslam Al-Abadi Ashish Chikermane Pamela Dawson Scott Hackett Deepthi Jyothish Hari Krishnan Kanthimathinathan Sean Monaghan Prasad Nagakumar Barnaby R. Scholefield Steven Welch Naeem Khan Sian Faustini Kate Davies Wioleta M. Zelek Pamela Kearns Graham S. Taylor
author_facet	Eleni Syrimi Eanna Fennell Alex Richter Pavle Vrljicak Richard Stark Sascha Ott Paul G. Murray Eslam Al-Abadi Ashish Chikermane Pamela Dawson Scott Hackett Deepthi Jyothish Hari Krishnan Kanthimathinathan Sean Monaghan Prasad Nagakumar Barnaby R. Scholefield Steven Welch Naeem Khan Sian Faustini Kate Davies Wioleta M. Zelek Pamela Kearns Graham S. Taylor
author_sort	Eleni Syrimi
title	The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
title_short	The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
title_full	The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
title_fullStr	The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
title_full_unstemmed	The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery
title_sort	immune landscape of sars-cov-2-associated multisystem inflammatory syndrome in children (mis-c) from acute disease to recovery
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cb7ebce799514eb180b30ec967fb855b
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The immune landscape of SARS-CoV-2-associated Multisystem Inflammatory Syndrome in Children (MIS-C) from acute disease to recovery

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