Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Abstract Amyotrophic Lateral Sclerosis (ALS) is a lethal neurodegenerative disorder that primarily affects motor neurons. Dominant mutations in the RNA binding protein Fused in Sarcoma (FUS) have been identified as causative factors of ALS. Mutation, R495X, results in a premature stop codon and indu...

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Auteurs principaux: Tadashi Nakaya, Manolis Maragkakis
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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R
Q
Accès en ligne:https://doaj.org/article/cb8569e4b09147fbb1c3b6d12bdc69e5
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