PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics

Abstract Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesting to investigate in humans subjected to...

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Autores principales:	C. Strewe, R. Zeller, M. Feuerecker, M. Hoerl, S. Matzel, I. Kumprej, A. Crispin, B. Johannes, T. Debevec, I. B. Mekjavic, O. Eiken, M. Thiel, G. Schelling, A. Choukèr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cb85ad13eccf4650b15125169bf9d946
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spelling	oai:doaj.org-article:cb85ad13eccf4650b15125169bf9d9462021-12-02T15:08:28ZPlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics10.1038/s41598-018-20045-52045-2322https://doaj.org/article/cb85ad13eccf4650b15125169bf9d9462018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20045-5https://doaj.org/toc/2045-2322Abstract Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesting to investigate in humans subjected to low oxygen conditions. Especially for space exploration scenarios, hypoxic conditions – together with reduced gravity - represent two foreseen living conditions when planning manned long-duration space missions or planetary habitats. The PlanHab study investigated microgravity through inactivity in bed rest and normobaric hypoxia to examine their independent or combined effect on adenosine and its kinetics. Healthy male subjects (n = 14) completed three 21-day interventions: hypoxic bed rest (HBR); hypoxic ambulatory confinement (HAMB); normoxic bed rest (NBR). The interventions were separated by 4 months. Our hypothesis of a hypoxia-triggered increase in adenosine was confirmed in HAMB but unexpectedly also in NBR. However, the highest adenosine levels were noted following HBR. Furthermore, the percentage of hemolysis was elevated in HBR whereas endothelial integrity markers stayed low in all three interventions. In summary, these data suggest that neocytolysis accounts for these effects while we could reduce evidence for microcirculatory changes.C. StreweR. ZellerM. FeuereckerM. HoerlS. MatzelI. KumprejA. CrispinB. JohannesT. DebevecI. B. MekjavicO. EikenM. ThielG. SchellingA. ChoukèrNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q C. Strewe R. Zeller M. Feuerecker M. Hoerl S. Matzel I. Kumprej A. Crispin B. Johannes T. Debevec I. B. Mekjavic O. Eiken M. Thiel G. Schelling A. Choukèr PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
description	Abstract Adenosine plays a role in the energy supply of cells and provokes differential, hormone-like functions in circulating cells and various tissues. Its release is importantly regulated by oxygen tension. This renders adenosine and its kinetics interesting to investigate in humans subjected to low oxygen conditions. Especially for space exploration scenarios, hypoxic conditions – together with reduced gravity - represent two foreseen living conditions when planning manned long-duration space missions or planetary habitats. The PlanHab study investigated microgravity through inactivity in bed rest and normobaric hypoxia to examine their independent or combined effect on adenosine and its kinetics. Healthy male subjects (n = 14) completed three 21-day interventions: hypoxic bed rest (HBR); hypoxic ambulatory confinement (HAMB); normoxic bed rest (NBR). The interventions were separated by 4 months. Our hypothesis of a hypoxia-triggered increase in adenosine was confirmed in HAMB but unexpectedly also in NBR. However, the highest adenosine levels were noted following HBR. Furthermore, the percentage of hemolysis was elevated in HBR whereas endothelial integrity markers stayed low in all three interventions. In summary, these data suggest that neocytolysis accounts for these effects while we could reduce evidence for microcirculatory changes.
format	article
author	C. Strewe R. Zeller M. Feuerecker M. Hoerl S. Matzel I. Kumprej A. Crispin B. Johannes T. Debevec I. B. Mekjavic O. Eiken M. Thiel G. Schelling A. Choukèr
author_facet	C. Strewe R. Zeller M. Feuerecker M. Hoerl S. Matzel I. Kumprej A. Crispin B. Johannes T. Debevec I. B. Mekjavic O. Eiken M. Thiel G. Schelling A. Choukèr
author_sort	C. Strewe
title	PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
title_short	PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
title_full	PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
title_fullStr	PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
title_full_unstemmed	PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
title_sort	planhab study: consequences of combined normobaric hypoxia and bed rest on adenosine kinetics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cb85ad13eccf4650b15125169bf9d946
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PlanHab Study: Consequences of combined normobaric hypoxia and bed rest on adenosine kinetics

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