Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension

Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature...

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Autores principales:	Mazen Shihan, Tatyana Novoyatleva, Thilo Lehmeyer, Akylbek Sydykov, Ralph T. Schermuly
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pulmonary arterial hypertension purinergic P2Y2 receptor pharmacological approach Medicine R
Acceso en línea:	https://doaj.org/article/cb85d7240ad242738d67aa549ac4c268
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spelling	oai:doaj.org-article:cb85d7240ad242738d67aa549ac4c2682021-11-11T16:10:12ZRole of the Purinergic P2Y2 Receptor in Pulmonary Hypertension10.3390/ijerph1821110091660-46011661-7827https://doaj.org/article/cb85d7240ad242738d67aa549ac4c2682021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11009https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature, endothelial cell dysfunction, and vascular tone dysregulation. The disease pathomechanisms, however, are as yet not fully understood at the molecular level. Purinergic receptors P2Y within the G-protein-coupled receptor family play a major role in fluid shear stress transduction, proliferation, migration, and vascular tone regulation in systemic circulation, but less is known about their contribution in PAH. Hence, studies that focus on purinergic signaling are of great importance for the identification of new therapeutic targets in PAH. Interestingly, the role of P2Y2 receptors has not yet been sufficiently studied in PAH, whereas the relevance of other P2Ys as drug targets for PAH was shown using specific agonists or antagonists. In this review, we will shed light on P2Y receptors and focus more on the P2Y2 receptor as a potential novel player in PAH and as a new therapeutic target for disease management.Mazen ShihanTatyana NovoyatlevaThilo LehmeyerAkylbek SydykovRalph T. SchermulyMDPI AGarticlepulmonary arterial hypertensionpurinergic P2Y2 receptorpharmacological approachMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11009, p 11009 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulmonary arterial hypertension purinergic P2Y2 receptor pharmacological approach Medicine R
spellingShingle	pulmonary arterial hypertension purinergic P2Y2 receptor pharmacological approach Medicine R Mazen Shihan Tatyana Novoyatleva Thilo Lehmeyer Akylbek Sydykov Ralph T. Schermuly Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
description	Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular remodeling, hyperproliferation in the vasculature, endothelial cell dysfunction, and vascular tone dysregulation. The disease pathomechanisms, however, are as yet not fully understood at the molecular level. Purinergic receptors P2Y within the G-protein-coupled receptor family play a major role in fluid shear stress transduction, proliferation, migration, and vascular tone regulation in systemic circulation, but less is known about their contribution in PAH. Hence, studies that focus on purinergic signaling are of great importance for the identification of new therapeutic targets in PAH. Interestingly, the role of P2Y2 receptors has not yet been sufficiently studied in PAH, whereas the relevance of other P2Ys as drug targets for PAH was shown using specific agonists or antagonists. In this review, we will shed light on P2Y receptors and focus more on the P2Y2 receptor as a potential novel player in PAH and as a new therapeutic target for disease management.
format	article
author	Mazen Shihan Tatyana Novoyatleva Thilo Lehmeyer Akylbek Sydykov Ralph T. Schermuly
author_facet	Mazen Shihan Tatyana Novoyatleva Thilo Lehmeyer Akylbek Sydykov Ralph T. Schermuly
author_sort	Mazen Shihan
title	Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_short	Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_full	Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_fullStr	Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_full_unstemmed	Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension
title_sort	role of the purinergic p2y2 receptor in pulmonary hypertension
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cb85d7240ad242738d67aa549ac4c268
work_keys_str_mv	AT mazenshihan roleofthepurinergicp2y2receptorinpulmonaryhypertension AT tatyananovoyatleva roleofthepurinergicp2y2receptorinpulmonaryhypertension AT thilolehmeyer roleofthepurinergicp2y2receptorinpulmonaryhypertension AT akylbeksydykov roleofthepurinergicp2y2receptorinpulmonaryhypertension AT ralphtschermuly roleofthepurinergicp2y2receptorinpulmonaryhypertension
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Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension

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