PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION

We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequ...

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Autores principales: A. V. Shevchenko, O. V. Golovanova, V. I. Konenkov, M. I. Voevoda, V. N. Maximov
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Lenguaje:RU
Publicado: SPb RAACI 2014
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Acceso en línea:https://doaj.org/article/cb87d8258f68484e9eae1a024309ed8c
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spelling oai:doaj.org-article:cb87d8258f68484e9eae1a024309ed8c2021-11-18T08:03:37ZPROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION1563-06252313-741X10.15789/1563-0625-2010-3-219-226https://doaj.org/article/cb87d8258f68484e9eae1a024309ed8c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/95https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations.A. V. ShevchenkoO. V. GolovanovaV. I. KonenkovM. I. VoevodaV. N. MaximovSPb RAACIarticlemyocardial infarctionil-1β gene polymorphismconventional risk factorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 3, Pp 219-226 (2014)
institution DOAJ
collection DOAJ
language RU
topic myocardial infarction
il-1β gene polymorphism
conventional risk factors
Immunologic diseases. Allergy
RC581-607
spellingShingle myocardial infarction
il-1β gene polymorphism
conventional risk factors
Immunologic diseases. Allergy
RC581-607
A. V. Shevchenko
O. V. Golovanova
V. I. Konenkov
M. I. Voevoda
V. N. Maximov
PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
description We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations.
format article
author A. V. Shevchenko
O. V. Golovanova
V. I. Konenkov
M. I. Voevoda
V. N. Maximov
author_facet A. V. Shevchenko
O. V. Golovanova
V. I. Konenkov
M. I. Voevoda
V. N. Maximov
author_sort A. V. Shevchenko
title PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_short PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_full PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_fullStr PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_full_unstemmed PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_sort promoter polymorphism of il-1β gene in patients with a history of acute myocardial infarction
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/cb87d8258f68484e9eae1a024309ed8c
work_keys_str_mv AT avshevchenko promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction
AT ovgolovanova promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction
AT vikonenkov promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction
AT mivoevoda promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction
AT vnmaximov promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction
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