PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION

We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequ...

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Auteurs principaux:	A. V. Shevchenko, O. V. Golovanova, V. I. Konenkov, M. I. Voevoda, V. N. Maximov
Format:	article
Langue:	RU
Publié:	SPb RAACI 2014
Sujets:	myocardial infarction il-1β gene polymorphism conventional risk factors Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/cb87d8258f68484e9eae1a024309ed8c
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spelling	oai:doaj.org-article:cb87d8258f68484e9eae1a024309ed8c2021-11-18T08:03:37ZPROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION1563-06252313-741X10.15789/1563-0625-2010-3-219-226https://doaj.org/article/cb87d8258f68484e9eae1a024309ed8c2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/95https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWe have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations.A. V. ShevchenkoO. V. GolovanovaV. I. KonenkovM. I. VoevodaV. N. MaximovSPb RAACIarticlemyocardial infarctionil-1β gene polymorphismconventional risk factorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 3, Pp 219-226 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	myocardial infarction il-1β gene polymorphism conventional risk factors Immunologic diseases. Allergy RC581-607
spellingShingle	myocardial infarction il-1β gene polymorphism conventional risk factors Immunologic diseases. Allergy RC581-607 A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
description	We have performed analysis of associations between IL-1β gene promoter polymorphism (-511C/T and -31 T/C variants), and conventional cardiovascular risk factors in the patients living in the West Siberia who had previously a history of myocardial infarction (MI). We are shown a strong linkage disequilibrium between IL-1β -31C/T (rs1143627), and IL-1β-511T/C (rs16944). Significant differences in frequency distributions of some compound genotypes were observed between healthy and patients with a history of MI. E.g., frequency of IL-1β-31CC/-511CT genotype was detected in 5.5 % of healthy population, while being absent among MI patients. A frequency of IL-1β (-31/-511) CC/CT genotype showed significant differences between MI patients under 55 years, as compared to healthy persons. Hence, the analyzed IL-1β promoter polymorphisms may be considered as an additional constitutional factor predisposing for vascular alterations.
format	article
author	A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov
author_facet	A. V. Shevchenko O. V. Golovanova V. I. Konenkov M. I. Voevoda V. N. Maximov
author_sort	A. V. Shevchenko
title	PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_short	PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_full	PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_fullStr	PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_full_unstemmed	PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION
title_sort	promoter polymorphism of il-1β gene in patients with a history of acute myocardial infarction
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cb87d8258f68484e9eae1a024309ed8c
work_keys_str_mv	AT avshevchenko promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction AT ovgolovanova promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction AT vikonenkov promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction AT mivoevoda promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction AT vnmaximov promoterpolymorphismofil1bgeneinpatientswithahistoryofacutemyocardialinfarction
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PROMOTER POLYMORPHISM OF IL-1β GENE IN PATIENTS WITH A HISTORY OF ACUTE MYOCARDIAL INFARCTION

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