Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models

Background and Objective: Many natural bioactive chemicals have been shown to have functional activity, suggesting that they could be useful in the treatment and management of a wide range of chronic conditions. Flavonoids, which include gallic acid (GA), are the most abundant polyphenols found in n...

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Autores principales:	Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Farhana Yasmin
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	GA Skeletal muscle relaxant Climbing test Chimney test Inverted test Diazepam Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cb8a02d35a134e1abe3856e3a490caa3
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spelling	oai:doaj.org-article:cb8a02d35a134e1abe3856e3a490caa32021-11-20T04:57:23ZPotential benefits of gallic acid as skeletal muscle relaxant in animal experimental models1319-562X10.1016/j.sjbs.2021.09.060https://doaj.org/article/cb8a02d35a134e1abe3856e3a490caa32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21008627https://doaj.org/toc/1319-562XBackground and Objective: Many natural bioactive chemicals have been shown to have functional activity, suggesting that they could be useful in the treatment and management of a wide range of chronic conditions. Flavonoids, which include gallic acid (GA), are the most abundant polyphenols found in nature. Skeletal muscle relaxants are drugs that reduce undesired spasms while maintaining awareness and reflexes unaffected. The purpose of this investigation was to determine if GA has any skeletal muscle relaxant properties in experimental animal models. Materials and Methods: The muscle relaxant activity of three dosages of GA (5, 10, and 20 mg/kg) was compared to that of normal diazepam (5 mg/kg) utilizing climbing, chimney, and modified Kondziela's inverted tests. An analysis of variance (ANOVA) and a post-ANOVA Tukey multiple comparisons test were used to assess the data. Results: Animals given 10 and 20 mg/kg of GA had a great deal of trouble climbing up the chain, presumably because their muscles were relaxed. Similarly, rats given a high dose of GA (20 mg/kg) had a significantly (P < 0.05) longer response time in the chimney test, indicating a lack of attention and slowed muscle tone, resulting in problems with motor coordination. In inverted testing, animals given a high dose of GA had a significantly (P < 0.01) reduced holding capacity on the mesh for a longer period of time. A decrease in holding time is caused by a decrease in muscular contraction. The low dose of GA, on the other hand, failed to show muscle relaxant effect in any of the three models. Conclusions: As a conclusion, our data show that GA has a dose-dependent skeletal muscle relaxant effect when administered orally to mice.Syed Mohammed Basheeruddin AsdaqAbdulhakeem S. AlamriWalaa F. AlsanieMajid AlhomraniFarhana YasminElsevierarticleGASkeletal muscle relaxantClimbing testChimney testInverted testDiazepamBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7575-7580 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GA Skeletal muscle relaxant Climbing test Chimney test Inverted test Diazepam Biology (General) QH301-705.5
spellingShingle	GA Skeletal muscle relaxant Climbing test Chimney test Inverted test Diazepam Biology (General) QH301-705.5 Syed Mohammed Basheeruddin Asdaq Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani Farhana Yasmin Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
description	Background and Objective: Many natural bioactive chemicals have been shown to have functional activity, suggesting that they could be useful in the treatment and management of a wide range of chronic conditions. Flavonoids, which include gallic acid (GA), are the most abundant polyphenols found in nature. Skeletal muscle relaxants are drugs that reduce undesired spasms while maintaining awareness and reflexes unaffected. The purpose of this investigation was to determine if GA has any skeletal muscle relaxant properties in experimental animal models. Materials and Methods: The muscle relaxant activity of three dosages of GA (5, 10, and 20 mg/kg) was compared to that of normal diazepam (5 mg/kg) utilizing climbing, chimney, and modified Kondziela's inverted tests. An analysis of variance (ANOVA) and a post-ANOVA Tukey multiple comparisons test were used to assess the data. Results: Animals given 10 and 20 mg/kg of GA had a great deal of trouble climbing up the chain, presumably because their muscles were relaxed. Similarly, rats given a high dose of GA (20 mg/kg) had a significantly (P < 0.05) longer response time in the chimney test, indicating a lack of attention and slowed muscle tone, resulting in problems with motor coordination. In inverted testing, animals given a high dose of GA had a significantly (P < 0.01) reduced holding capacity on the mesh for a longer period of time. A decrease in holding time is caused by a decrease in muscular contraction. The low dose of GA, on the other hand, failed to show muscle relaxant effect in any of the three models. Conclusions: As a conclusion, our data show that GA has a dose-dependent skeletal muscle relaxant effect when administered orally to mice.
format	article
author	Syed Mohammed Basheeruddin Asdaq Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani Farhana Yasmin
author_facet	Syed Mohammed Basheeruddin Asdaq Abdulhakeem S. Alamri Walaa F. Alsanie Majid Alhomrani Farhana Yasmin
author_sort	Syed Mohammed Basheeruddin Asdaq
title	Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_short	Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_full	Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_fullStr	Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_full_unstemmed	Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_sort	potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/cb8a02d35a134e1abe3856e3a490caa3
work_keys_str_mv	AT syedmohammedbasheeruddinasdaq potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels AT abdulhakeemsalamri potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels AT walaafalsanie potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels AT majidalhomrani potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels AT farhanayasmin potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels
_version_	1718419740725084160

Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models

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