Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models

Background and Objective: Many natural bioactive chemicals have been shown to have functional activity, suggesting that they could be useful in the treatment and management of a wide range of chronic conditions. Flavonoids, which include gallic acid (GA), are the most abundant polyphenols found in n...

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Auteurs principaux: Syed Mohammed Basheeruddin Asdaq, Abdulhakeem S. Alamri, Walaa F. Alsanie, Majid Alhomrani, Farhana Yasmin
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Publié: Elsevier 2021
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spelling oai:doaj.org-article:cb8a02d35a134e1abe3856e3a490caa32021-11-20T04:57:23ZPotential benefits of gallic acid as skeletal muscle relaxant in animal experimental models1319-562X10.1016/j.sjbs.2021.09.060https://doaj.org/article/cb8a02d35a134e1abe3856e3a490caa32021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1319562X21008627https://doaj.org/toc/1319-562XBackground and Objective: Many natural bioactive chemicals have been shown to have functional activity, suggesting that they could be useful in the treatment and management of a wide range of chronic conditions. Flavonoids, which include gallic acid (GA), are the most abundant polyphenols found in nature. Skeletal muscle relaxants are drugs that reduce undesired spasms while maintaining awareness and reflexes unaffected. The purpose of this investigation was to determine if GA has any skeletal muscle relaxant properties in experimental animal models. Materials and Methods: The muscle relaxant activity of three dosages of GA (5, 10, and 20 mg/kg) was compared to that of normal diazepam (5 mg/kg) utilizing climbing, chimney, and modified Kondziela's inverted tests. An analysis of variance (ANOVA) and a post-ANOVA Tukey multiple comparisons test were used to assess the data. Results: Animals given 10 and 20 mg/kg of GA had a great deal of trouble climbing up the chain, presumably because their muscles were relaxed. Similarly, rats given a high dose of GA (20 mg/kg) had a significantly (P < 0.05) longer response time in the chimney test, indicating a lack of attention and slowed muscle tone, resulting in problems with motor coordination. In inverted testing, animals given a high dose of GA had a significantly (P < 0.01) reduced holding capacity on the mesh for a longer period of time. A decrease in holding time is caused by a decrease in muscular contraction. The low dose of GA, on the other hand, failed to show muscle relaxant effect in any of the three models. Conclusions: As a conclusion, our data show that GA has a dose-dependent skeletal muscle relaxant effect when administered orally to mice.Syed Mohammed Basheeruddin AsdaqAbdulhakeem S. AlamriWalaa F. AlsanieMajid AlhomraniFarhana YasminElsevierarticleGASkeletal muscle relaxantClimbing testChimney testInverted testDiazepamBiology (General)QH301-705.5ENSaudi Journal of Biological Sciences, Vol 28, Iss 12, Pp 7575-7580 (2021)
institution DOAJ
collection DOAJ
language EN
topic GA
Skeletal muscle relaxant
Climbing test
Chimney test
Inverted test
Diazepam
Biology (General)
QH301-705.5
spellingShingle GA
Skeletal muscle relaxant
Climbing test
Chimney test
Inverted test
Diazepam
Biology (General)
QH301-705.5
Syed Mohammed Basheeruddin Asdaq
Abdulhakeem S. Alamri
Walaa F. Alsanie
Majid Alhomrani
Farhana Yasmin
Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
description Background and Objective: Many natural bioactive chemicals have been shown to have functional activity, suggesting that they could be useful in the treatment and management of a wide range of chronic conditions. Flavonoids, which include gallic acid (GA), are the most abundant polyphenols found in nature. Skeletal muscle relaxants are drugs that reduce undesired spasms while maintaining awareness and reflexes unaffected. The purpose of this investigation was to determine if GA has any skeletal muscle relaxant properties in experimental animal models. Materials and Methods: The muscle relaxant activity of three dosages of GA (5, 10, and 20 mg/kg) was compared to that of normal diazepam (5 mg/kg) utilizing climbing, chimney, and modified Kondziela's inverted tests. An analysis of variance (ANOVA) and a post-ANOVA Tukey multiple comparisons test were used to assess the data. Results: Animals given 10 and 20 mg/kg of GA had a great deal of trouble climbing up the chain, presumably because their muscles were relaxed. Similarly, rats given a high dose of GA (20 mg/kg) had a significantly (P < 0.05) longer response time in the chimney test, indicating a lack of attention and slowed muscle tone, resulting in problems with motor coordination. In inverted testing, animals given a high dose of GA had a significantly (P < 0.01) reduced holding capacity on the mesh for a longer period of time. A decrease in holding time is caused by a decrease in muscular contraction. The low dose of GA, on the other hand, failed to show muscle relaxant effect in any of the three models. Conclusions: As a conclusion, our data show that GA has a dose-dependent skeletal muscle relaxant effect when administered orally to mice.
format article
author Syed Mohammed Basheeruddin Asdaq
Abdulhakeem S. Alamri
Walaa F. Alsanie
Majid Alhomrani
Farhana Yasmin
author_facet Syed Mohammed Basheeruddin Asdaq
Abdulhakeem S. Alamri
Walaa F. Alsanie
Majid Alhomrani
Farhana Yasmin
author_sort Syed Mohammed Basheeruddin Asdaq
title Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_short Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_full Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_fullStr Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_full_unstemmed Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
title_sort potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models
publisher Elsevier
publishDate 2021
url https://doaj.org/article/cb8a02d35a134e1abe3856e3a490caa3
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AT walaafalsanie potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels
AT majidalhomrani potentialbenefitsofgallicacidasskeletalmusclerelaxantinanimalexperimentalmodels
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