Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment

Ovarian cancer is a heterogeneous disease and is also the major cause of death among women from gynecologic malignancies. A combination of surgery and chemotherapy is the major therapy for ovarian cancer. Unfortunately, despite good response rates to initial surgery and chemotherapy, most patients r...

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Autores principales:	Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	resveratrol ovarian cancer antitumor antioxidant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cb8fd9b048de414099671ed8e56ad66a
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spelling	oai:doaj.org-article:cb8fd9b048de414099671ed8e56ad66a2021-11-25T16:27:08ZResveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment10.3390/antiox101117182076-3921https://doaj.org/article/cb8fd9b048de414099671ed8e56ad66a2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1718https://doaj.org/toc/2076-3921Ovarian cancer is a heterogeneous disease and is also the major cause of death among women from gynecologic malignancies. A combination of surgery and chemotherapy is the major therapy for ovarian cancer. Unfortunately, despite good response rates to initial surgery and chemotherapy, most patients relapse and have a generally poor survival rate. The present research sheds light on the therapeutic effects of multiple natural products in patients with ovarian cancer. Notably, these natural ingredients do not have adverse effects on healthy cells and tissues, indicating that natural products can serve as a safe alternative therapy for ovarian cancer. <i>Trans</i>-3,4,5′-Trihydroxystibene (resveratrol) is a natural product that is commonly found in the human diet and that has been shown to have anticancer effects on various human cancer cells. This review summarizes current knowledge regarding the progress of resveratrol against tumor cell proliferation, metastasis, apoptosis induction, autophagy, sensitization, and antioxidation as well as anti-inflammation. It also provides information regarding the role of resveratrol analogues in ovarian cancer. A better understanding of the role of resveratrol in ovarian cancer may provide a new array for the prevention and therapy of ovarian cancer.Xue-Ling XuShou-Long DengZheng-Xing LianKun YuMDPI AGarticleresveratrolovarian cancerantitumorantioxidantTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1718, p 1718 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resveratrol ovarian cancer antitumor antioxidant Therapeutics. Pharmacology RM1-950
spellingShingle	resveratrol ovarian cancer antitumor antioxidant Therapeutics. Pharmacology RM1-950 Xue-Ling Xu Shou-Long Deng Zheng-Xing Lian Kun Yu Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
description	Ovarian cancer is a heterogeneous disease and is also the major cause of death among women from gynecologic malignancies. A combination of surgery and chemotherapy is the major therapy for ovarian cancer. Unfortunately, despite good response rates to initial surgery and chemotherapy, most patients relapse and have a generally poor survival rate. The present research sheds light on the therapeutic effects of multiple natural products in patients with ovarian cancer. Notably, these natural ingredients do not have adverse effects on healthy cells and tissues, indicating that natural products can serve as a safe alternative therapy for ovarian cancer. <i>Trans</i>-3,4,5′-Trihydroxystibene (resveratrol) is a natural product that is commonly found in the human diet and that has been shown to have anticancer effects on various human cancer cells. This review summarizes current knowledge regarding the progress of resveratrol against tumor cell proliferation, metastasis, apoptosis induction, autophagy, sensitization, and antioxidation as well as anti-inflammation. It also provides information regarding the role of resveratrol analogues in ovarian cancer. A better understanding of the role of resveratrol in ovarian cancer may provide a new array for the prevention and therapy of ovarian cancer.
format	article
author	Xue-Ling Xu Shou-Long Deng Zheng-Xing Lian Kun Yu
author_facet	Xue-Ling Xu Shou-Long Deng Zheng-Xing Lian Kun Yu
author_sort	Xue-Ling Xu
title	Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
title_short	Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
title_full	Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
title_fullStr	Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
title_full_unstemmed	Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment
title_sort	resveratrol targets a variety of oncogenic and oncosuppressive signaling for ovarian cancer prevention and treatment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cb8fd9b048de414099671ed8e56ad66a
work_keys_str_mv	AT xuelingxu resveratroltargetsavarietyofoncogenicandoncosuppressivesignalingforovariancancerpreventionandtreatment AT shoulongdeng resveratroltargetsavarietyofoncogenicandoncosuppressivesignalingforovariancancerpreventionandtreatment AT zhengxinglian resveratroltargetsavarietyofoncogenicandoncosuppressivesignalingforovariancancerpreventionandtreatment AT kunyu resveratroltargetsavarietyofoncogenicandoncosuppressivesignalingforovariancancerpreventionandtreatment
_version_	1718413166882324480

Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment

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