On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma

Microwave ablation at 2.45 GHz is gaining popularity as an alternative therapy to hepatic resection with a higher overall survival rate than external beam radiation therapy and proton beam therapy. It also offers better long-term recurrence-free overall survival when compared with radiofrequency abl...

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Autores principales:	Branislav Radjenović, Martin Sabo, Lukaš Šoltes, Marta Prnova, Pavel Čičak, Marija Radmilović-Radjenović
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatocellular carcinoma microwave ablation necrotic tissue Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cb91b7ce25464cd7b51e73143ef5f894
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spelling	oai:doaj.org-article:cb91b7ce25464cd7b51e73143ef5f8942021-11-25T17:03:56ZOn Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma10.3390/cancers132257842072-6694https://doaj.org/article/cb91b7ce25464cd7b51e73143ef5f8942021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5784https://doaj.org/toc/2072-6694Microwave ablation at 2.45 GHz is gaining popularity as an alternative therapy to hepatic resection with a higher overall survival rate than external beam radiation therapy and proton beam therapy. It also offers better long-term recurrence-free overall survival when compared with radiofrequency ablation. To improve the design and optimization of microwave ablation procedures, numerical models can provide crucial information. A three-dimensional model of the antenna and targeted tissue without homogeneity assumptions are the most realistic representation of the physical problem. Due to complexity and computational resources consumption, most of the existing numerical studies are based on using two-dimensional axisymmetric models to emulate actual three-dimensional cancers and surrounding tissue, which is often far from reality. The main goal of this study is to develop a fully three-dimensional model of a multislot microwave antenna immersed into liver tissue affected by early-stage hepatocellular carcinoma. The geometry of the tumor is taken from the 3D-IRCADb-01 liver tumors database. Simulations were performed involving the temperature dependence of the blood perfusion, dielectric and thermal properties of both healthy and tumoral liver tissues. The water content changes during the ablation process are also included. The optimal values of the input power and the ablation time are determined to ensure complete treatment of the tumor with minimal damage to the healthy tissue. It was found that a multislot antenna is designed to create predictable, large, spherical zones of the ablation that are not influenced by varying tissue environments. The obtained results may be useful for determining optimal conditions necessary for microwave ablation to be as effective as possible for treating early-stage hepatocellular carcinoma, with minimized invasiveness and collateral damages.Branislav RadjenovićMartin SaboLukaš ŠoltesMarta PrnovaPavel ČičakMarija Radmilović-RadjenovićMDPI AGarticlehepatocellular carcinomamicrowave ablationnecrotic tissueNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5784, p 5784 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma microwave ablation necrotic tissue Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	hepatocellular carcinoma microwave ablation necrotic tissue Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Branislav Radjenović Martin Sabo Lukaš Šoltes Marta Prnova Pavel Čičak Marija Radmilović-Radjenović On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma
description	Microwave ablation at 2.45 GHz is gaining popularity as an alternative therapy to hepatic resection with a higher overall survival rate than external beam radiation therapy and proton beam therapy. It also offers better long-term recurrence-free overall survival when compared with radiofrequency ablation. To improve the design and optimization of microwave ablation procedures, numerical models can provide crucial information. A three-dimensional model of the antenna and targeted tissue without homogeneity assumptions are the most realistic representation of the physical problem. Due to complexity and computational resources consumption, most of the existing numerical studies are based on using two-dimensional axisymmetric models to emulate actual three-dimensional cancers and surrounding tissue, which is often far from reality. The main goal of this study is to develop a fully three-dimensional model of a multislot microwave antenna immersed into liver tissue affected by early-stage hepatocellular carcinoma. The geometry of the tumor is taken from the 3D-IRCADb-01 liver tumors database. Simulations were performed involving the temperature dependence of the blood perfusion, dielectric and thermal properties of both healthy and tumoral liver tissues. The water content changes during the ablation process are also included. The optimal values of the input power and the ablation time are determined to ensure complete treatment of the tumor with minimal damage to the healthy tissue. It was found that a multislot antenna is designed to create predictable, large, spherical zones of the ablation that are not influenced by varying tissue environments. The obtained results may be useful for determining optimal conditions necessary for microwave ablation to be as effective as possible for treating early-stage hepatocellular carcinoma, with minimized invasiveness and collateral damages.
format	article
author	Branislav Radjenović Martin Sabo Lukaš Šoltes Marta Prnova Pavel Čičak Marija Radmilović-Radjenović
author_facet	Branislav Radjenović Martin Sabo Lukaš Šoltes Marta Prnova Pavel Čičak Marija Radmilović-Radjenović
author_sort	Branislav Radjenović
title	On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma
title_short	On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma
title_full	On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma
title_fullStr	On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma
title_full_unstemmed	On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma
title_sort	on efficacy of microwave ablation in the thermal treatment of an early-stage hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cb91b7ce25464cd7b51e73143ef5f894
work_keys_str_mv	AT branislavradjenovic onefficacyofmicrowaveablationinthethermaltreatmentofanearlystagehepatocellularcarcinoma AT martinsabo onefficacyofmicrowaveablationinthethermaltreatmentofanearlystagehepatocellularcarcinoma AT lukassoltes onefficacyofmicrowaveablationinthethermaltreatmentofanearlystagehepatocellularcarcinoma AT martaprnova onefficacyofmicrowaveablationinthethermaltreatmentofanearlystagehepatocellularcarcinoma AT pavelcicak onefficacyofmicrowaveablationinthethermaltreatmentofanearlystagehepatocellularcarcinoma AT marijaradmilovicradjenovic onefficacyofmicrowaveablationinthethermaltreatmentofanearlystagehepatocellularcarcinoma
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On Efficacy of Microwave Ablation in the Thermal Treatment of an Early-Stage Hepatocellular Carcinoma

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