Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes

Jaret Malloy, Kate Gurney, Kevin Shan, Ping Yan, Steve ChenAmylin Pharmaceuticals LLC, San Diego, CABackground: Recent studies have demonstrated an increased incidence of pancreatitis in patients with type 2 diabetes compared with obese nondiabetic individuals. Serum lipase and pancreatic amylase co...

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Autores principales:	Malloy J, Gurney K, Shan K, Yan P, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/cb92757f130b475d9e488e8958ab1851
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spelling	oai:doaj.org-article:cb92757f130b475d9e488e8958ab18512021-12-02T04:59:17ZIncreased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes1178-7007https://doaj.org/article/cb92757f130b475d9e488e8958ab18512012-12-01T00:00:00Zhttp://www.dovepress.com/increased-variability-and-abnormalities-in-pancreatic-enzyme-concentra-a11763https://doaj.org/toc/1178-7007Jaret Malloy, Kate Gurney, Kevin Shan, Ping Yan, Steve ChenAmylin Pharmaceuticals LLC, San Diego, CABackground: Recent studies have demonstrated an increased incidence of pancreatitis in patients with type 2 diabetes compared with obese nondiabetic individuals. Serum lipase and pancreatic amylase concentrations are used in conjunction with clinical findings to diagnose pancreatitis.Methods: In two large clinical trials of overweight/obese nondiabetic and type 2 diabetic subjects, lipase and pancreatic amylase were measured at screening and 2&ndash;5 weeks later at baseline (prior to treatment with study medication).Results: Lipase and pancreatic amylase concentrations were above the upper limit of normal (ULN) in 13% and 6% of type 2 diabetic subjects, respectively, and were approximately three-fold (3 &times;) higher than the proportion of nondiabetic subjects with levels above ULN. Elevations exceeding ULN were seen in many subjects asymptomatic for pancreatitis; however, elevations &gt;2 &times; ULN and &gt;3 &times; ULN were uncommon, and elevations &gt;3 &times; ULN were often associated with a history of dyslipidemia, hyperlipidemia, and gastrointestinal disorders. Additionally, enzyme concentrations varied within this 2&ndash;5-week screening period, including shifts between elevated and normal levels.Conclusion: Results from this post hoc analysis suggest that, although pancreatic enzymes can be a useful marker for pancreatitis within the proper clinical context, diagnosis of pancreatitis may be confounded in populations known to have asymptomatic elevations associated with disease, such as type 2 diabetes. Further effort is needed to clarify the etiology and epidemiology of pancreatic enzyme elevations in type 2 diabetes.Keywords: diabetes, pancreatitis, amylase, lipaseMalloy JGurney KShan KYan PChen SDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2012, Iss default, Pp 419-424 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Malloy J Gurney K Shan K Yan P Chen S Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
description	Jaret Malloy, Kate Gurney, Kevin Shan, Ping Yan, Steve ChenAmylin Pharmaceuticals LLC, San Diego, CABackground: Recent studies have demonstrated an increased incidence of pancreatitis in patients with type 2 diabetes compared with obese nondiabetic individuals. Serum lipase and pancreatic amylase concentrations are used in conjunction with clinical findings to diagnose pancreatitis.Methods: In two large clinical trials of overweight/obese nondiabetic and type 2 diabetic subjects, lipase and pancreatic amylase were measured at screening and 2&ndash;5 weeks later at baseline (prior to treatment with study medication).Results: Lipase and pancreatic amylase concentrations were above the upper limit of normal (ULN) in 13% and 6% of type 2 diabetic subjects, respectively, and were approximately three-fold (3 &times;) higher than the proportion of nondiabetic subjects with levels above ULN. Elevations exceeding ULN were seen in many subjects asymptomatic for pancreatitis; however, elevations &gt;2 &times; ULN and &gt;3 &times; ULN were uncommon, and elevations &gt;3 &times; ULN were often associated with a history of dyslipidemia, hyperlipidemia, and gastrointestinal disorders. Additionally, enzyme concentrations varied within this 2&ndash;5-week screening period, including shifts between elevated and normal levels.Conclusion: Results from this post hoc analysis suggest that, although pancreatic enzymes can be a useful marker for pancreatitis within the proper clinical context, diagnosis of pancreatitis may be confounded in populations known to have asymptomatic elevations associated with disease, such as type 2 diabetes. Further effort is needed to clarify the etiology and epidemiology of pancreatic enzyme elevations in type 2 diabetes.Keywords: diabetes, pancreatitis, amylase, lipase
format	article
author	Malloy J Gurney K Shan K Yan P Chen S
author_facet	Malloy J Gurney K Shan K Yan P Chen S
author_sort	Malloy J
title	Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
title_short	Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
title_full	Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
title_fullStr	Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
title_full_unstemmed	Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
title_sort	increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/cb92757f130b475d9e488e8958ab1851
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Increased variability and abnormalities in pancreatic enzyme concentrations in otherwise asymptomatic subjects with type 2 diabetes

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