Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine

(‒)-Morphine is an essential medicine selected by the World Health Organization, however its catalytic asymmetric syntheses have been rarely reported. Here, the authors developed an intramolecular enantioselective Michael addition leading to (‒)-morphine in a longest linear sequence of 16 steps.

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Autores principales:	Qing Zhang, Fu-Min Zhang, Chang-Sheng Zhang, Si-Zhan Liu, Jin-Miao Tian, Shao-Hua Wang, Xiao-Ming Zhang, Yong-Qiang Tu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb927e17afa2486397458cec4dc97f09
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spelling	oai:doaj.org-article:cb927e17afa2486397458cec4dc97f092021-12-02T14:38:43ZEnantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine10.1038/s41467-019-10398-42041-1723https://doaj.org/article/cb927e17afa2486397458cec4dc97f092019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10398-4https://doaj.org/toc/2041-1723(‒)-Morphine is an essential medicine selected by the World Health Organization, however its catalytic asymmetric syntheses have been rarely reported. Here, the authors developed an intramolecular enantioselective Michael addition leading to (‒)-morphine in a longest linear sequence of 16 steps.Qing ZhangFu-Min ZhangChang-Sheng ZhangSi-Zhan LiuJin-Miao TianShao-Hua WangXiao-Ming ZhangYong-Qiang TuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing Zhang Fu-Min Zhang Chang-Sheng Zhang Si-Zhan Liu Jin-Miao Tian Shao-Hua Wang Xiao-Ming Zhang Yong-Qiang Tu Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
description	(‒)-Morphine is an essential medicine selected by the World Health Organization, however its catalytic asymmetric syntheses have been rarely reported. Here, the authors developed an intramolecular enantioselective Michael addition leading to (‒)-morphine in a longest linear sequence of 16 steps.
format	article
author	Qing Zhang Fu-Min Zhang Chang-Sheng Zhang Si-Zhan Liu Jin-Miao Tian Shao-Hua Wang Xiao-Ming Zhang Yong-Qiang Tu
author_facet	Qing Zhang Fu-Min Zhang Chang-Sheng Zhang Si-Zhan Liu Jin-Miao Tian Shao-Hua Wang Xiao-Ming Zhang Yong-Qiang Tu
author_sort	Qing Zhang
title	Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
title_short	Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
title_full	Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
title_fullStr	Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
title_full_unstemmed	Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
title_sort	enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cb927e17afa2486397458cec4dc97f09
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Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine

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