Analysis of polygenic risk score usage and performance in diverse human populations

Predominant participation of European-ancestry individuals in genetic studies has hindered the better understanding of genetic risk in non-European ancestry individuals. Here, Duncan et al. quantify polygenic risk score use and performance in worldwide populations.

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Autores principales:	L. Duncan, H. Shen, B. Gelaye, J. Meijsen, K. Ressler, M. Feldman, R. Peterson, B. Domingue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb93a6b3791441d4a1f333febc9cc943
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spelling	oai:doaj.org-article:cb93a6b3791441d4a1f333febc9cc9432021-12-02T16:57:08ZAnalysis of polygenic risk score usage and performance in diverse human populations10.1038/s41467-019-11112-02041-1723https://doaj.org/article/cb93a6b3791441d4a1f333febc9cc9432019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11112-0https://doaj.org/toc/2041-1723Predominant participation of European-ancestry individuals in genetic studies has hindered the better understanding of genetic risk in non-European ancestry individuals. Here, Duncan et al. quantify polygenic risk score use and performance in worldwide populations.L. DuncanH. ShenB. GelayeJ. MeijsenK. ResslerM. FeldmanR. PetersonB. DomingueNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q L. Duncan H. Shen B. Gelaye J. Meijsen K. Ressler M. Feldman R. Peterson B. Domingue Analysis of polygenic risk score usage and performance in diverse human populations
description	Predominant participation of European-ancestry individuals in genetic studies has hindered the better understanding of genetic risk in non-European ancestry individuals. Here, Duncan et al. quantify polygenic risk score use and performance in worldwide populations.
format	article
author	L. Duncan H. Shen B. Gelaye J. Meijsen K. Ressler M. Feldman R. Peterson B. Domingue
author_facet	L. Duncan H. Shen B. Gelaye J. Meijsen K. Ressler M. Feldman R. Peterson B. Domingue
author_sort	L. Duncan
title	Analysis of polygenic risk score usage and performance in diverse human populations
title_short	Analysis of polygenic risk score usage and performance in diverse human populations
title_full	Analysis of polygenic risk score usage and performance in diverse human populations
title_fullStr	Analysis of polygenic risk score usage and performance in diverse human populations
title_full_unstemmed	Analysis of polygenic risk score usage and performance in diverse human populations
title_sort	analysis of polygenic risk score usage and performance in diverse human populations
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cb93a6b3791441d4a1f333febc9cc943
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Analysis of polygenic risk score usage and performance in diverse human populations

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