Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mausita Karmakar, Michael A. Katsnelson, George R. Dubyak, Eric Pearlman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb95f200ea844722806edee650b3641b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb95f200ea844722806edee650b3641b
record_format	dspace
spelling	oai:doaj.org-article:cb95f200ea844722806edee650b3641b2021-12-02T15:34:59ZNeutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP10.1038/ncomms105552041-1723https://doaj.org/article/cb95f200ea844722806edee650b3641b2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10555https://doaj.org/toc/2041-1723Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.Mausita KarmakarMichael A. KatsnelsonGeorge R. DubyakEric PearlmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mausita Karmakar Michael A. Katsnelson George R. Dubyak Eric Pearlman Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
description	Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion.
format	article
author	Mausita Karmakar Michael A. Katsnelson George R. Dubyak Eric Pearlman
author_facet	Mausita Karmakar Michael A. Katsnelson George R. Dubyak Eric Pearlman
author_sort	Mausita Karmakar
title	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_short	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_full	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_fullStr	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_full_unstemmed	Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP
title_sort	neutrophil p2x7 receptors mediate nlrp3 inflammasome-dependent il-1β secretion in response to atp
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cb95f200ea844722806edee650b3641b
work_keys_str_mv	AT mausitakarmakar neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp AT michaelakatsnelson neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp AT georgerdubyak neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp AT ericpearlman neutrophilp2x7receptorsmediatenlrp3inflammasomedependentil1bsecretioninresponsetoatp
_version_	1718386683396751360

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Ejemplares similares