Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed

We present a rare case of acute promyelocytic leukemia (APL) presenting as pulmonary thromboembolism being misdiagnosed as community.acquired pneumonia. Thrombotic phenomenon in APL are poorly understood and grossly underreported. In our case, following no response to standard antibiotic treatment,...

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Autores principales:	Ashok K Vaid, Sandeep Batra, Suman S Karanth, Sachin Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2015
Materias:	acute promyelocytic leukemia community-acquired pneumonia pulmonary thromboembolism Medicine R
Acceso en línea:	https://doaj.org/article/cb96aee429464a7bb944067e740d04b5
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spelling	oai:doaj.org-article:cb96aee429464a7bb944067e740d04b52021-12-02T16:24:57ZAcute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed2231-07702249-446410.4103/2231-0770.165125https://doaj.org/article/cb96aee429464a7bb944067e740d04b52015-10-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.165125https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464We present a rare case of acute promyelocytic leukemia (APL) presenting as pulmonary thromboembolism being misdiagnosed as community.acquired pneumonia. Thrombotic phenomenon in APL are poorly understood and grossly underreported. In our case, following no response to standard antibiotic treatment, the patient was further investigated and detected to have an acute pulmonary thromboembolism following right lower limb deep vein thrombosis (DVT). Though, complete blood picture revealed only mild hyperleukocytosis, bone marrow biopsy and aspiration revealed 60% blasts and a positive t (15,17)(q22,12) and PML retinoic acid receptor alpha (RARA) fusion protein on molecular cytogenetics. He was diagnosed as APL and received treatment with all.transretinoic acid (ATRA) and arsenic trioxide (ATO) and therapeutic anticoagulationAshok K VaidSandeep BatraSuman S KaranthSachin GuptaThieme Medical and Scientific Publishers Pvt. Ltd.articleacute promyelocytic leukemiacommunity-acquired pneumoniapulmonary thromboembolismMedicineRENAvicenna Journal of Medicine, Vol 05, Iss 04, Pp 131-133 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute promyelocytic leukemia community-acquired pneumonia pulmonary thromboembolism Medicine R
spellingShingle	acute promyelocytic leukemia community-acquired pneumonia pulmonary thromboembolism Medicine R Ashok K Vaid Sandeep Batra Suman S Karanth Sachin Gupta Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed
description	We present a rare case of acute promyelocytic leukemia (APL) presenting as pulmonary thromboembolism being misdiagnosed as community.acquired pneumonia. Thrombotic phenomenon in APL are poorly understood and grossly underreported. In our case, following no response to standard antibiotic treatment, the patient was further investigated and detected to have an acute pulmonary thromboembolism following right lower limb deep vein thrombosis (DVT). Though, complete blood picture revealed only mild hyperleukocytosis, bone marrow biopsy and aspiration revealed 60% blasts and a positive t (15,17)(q22,12) and PML retinoic acid receptor alpha (RARA) fusion protein on molecular cytogenetics. He was diagnosed as APL and received treatment with all.transretinoic acid (ATRA) and arsenic trioxide (ATO) and therapeutic anticoagulation
format	article
author	Ashok K Vaid Sandeep Batra Suman S Karanth Sachin Gupta
author_facet	Ashok K Vaid Sandeep Batra Suman S Karanth Sachin Gupta
author_sort	Ashok K Vaid
title	Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed
title_short	Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed
title_full	Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed
title_fullStr	Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed
title_full_unstemmed	Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed
title_sort	acute promyelocytic leukemia presenting as pulmonary thromboembolism: not all apls bleed
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2015
url	https://doaj.org/article/cb96aee429464a7bb944067e740d04b5
work_keys_str_mv	AT ashokkvaid acutepromyelocyticleukemiapresentingaspulmonarythromboembolismnotallaplsbleed AT sandeepbatra acutepromyelocyticleukemiapresentingaspulmonarythromboembolismnotallaplsbleed AT sumanskaranth acutepromyelocyticleukemiapresentingaspulmonarythromboembolismnotallaplsbleed AT sachingupta acutepromyelocyticleukemiapresentingaspulmonarythromboembolismnotallaplsbleed
_version_	1718384081779032064

Acute promyelocytic leukemia presenting as pulmonary thromboembolism: Not all APLs bleed

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