A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through a core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as the core fiber significantly improved the PLGA-based fi...

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Autores principales:	Shue Jin, Jing Gao, Renli Yang, Chen Yuan, Ruili Wang, Qin Zou, Yi Zuo, Meifang Zhu, Yubao Li, Yi Man, Jidong Li
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Coaxial nanofiber Baicalin Inflammation Osteoclast differentiation Vascularized bone regeneration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/cb987c41d73949f58ee6f624546c5d2d
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spelling	oai:doaj.org-article:cb987c41d73949f58ee6f624546c5d2d2021-11-04T04:35:59ZA baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration2452-199X10.1016/j.bioactmat.2021.06.028https://doaj.org/article/cb987c41d73949f58ee6f624546c5d2d2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003145https://doaj.org/toc/2452-199XWe demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through a core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as the core fiber significantly improved the PLGA-based fibrous scaffold's dimensional maintenance. We further utilized fish collagen to modify the PLGA shell layer (PFC) of coaxial fibers and loaded baicalin (BA) into the PCL core layer (PCL-BA) to endow fibrous scaffold with more functional biological cues. The PFC/PCL-BA fibrous scaffold promoted the osteogenic differentiation of bone mesenchymal stem cells and stimulated the RAW264.7 cells to polarize into a pro-reparative phenotype. Importantly, the in vivo study demonstrated that the PFC/PCL-BA scaffold could regulate inflammation and osteoclast differentiation, favor neovascularization and bone formation. This work tactfully combined PLGA and PCL to establish a drug release platform based on the core-shell fibrous scaffold for vascularized bone regeneration.Shue JinJing GaoRenli YangChen YuanRuili WangQin ZouYi ZuoMeifang ZhuYubao LiYi ManJidong LiKeAi Communications Co., Ltd.articleCoaxial nanofiberBaicalinInflammationOsteoclast differentiationVascularized bone regenerationMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 559-572 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coaxial nanofiber Baicalin Inflammation Osteoclast differentiation Vascularized bone regeneration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Coaxial nanofiber Baicalin Inflammation Osteoclast differentiation Vascularized bone regeneration Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Shue Jin Jing Gao Renli Yang Chen Yuan Ruili Wang Qin Zou Yi Zuo Meifang Zhu Yubao Li Yi Man Jidong Li A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
description	We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through a core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as the core fiber significantly improved the PLGA-based fibrous scaffold's dimensional maintenance. We further utilized fish collagen to modify the PLGA shell layer (PFC) of coaxial fibers and loaded baicalin (BA) into the PCL core layer (PCL-BA) to endow fibrous scaffold with more functional biological cues. The PFC/PCL-BA fibrous scaffold promoted the osteogenic differentiation of bone mesenchymal stem cells and stimulated the RAW264.7 cells to polarize into a pro-reparative phenotype. Importantly, the in vivo study demonstrated that the PFC/PCL-BA scaffold could regulate inflammation and osteoclast differentiation, favor neovascularization and bone formation. This work tactfully combined PLGA and PCL to establish a drug release platform based on the core-shell fibrous scaffold for vascularized bone regeneration.
format	article
author	Shue Jin Jing Gao Renli Yang Chen Yuan Ruili Wang Qin Zou Yi Zuo Meifang Zhu Yubao Li Yi Man Jidong Li
author_facet	Shue Jin Jing Gao Renli Yang Chen Yuan Ruili Wang Qin Zou Yi Zuo Meifang Zhu Yubao Li Yi Man Jidong Li
author_sort	Shue Jin
title	A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
title_short	A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
title_full	A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
title_fullStr	A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
title_full_unstemmed	A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
title_sort	baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/cb987c41d73949f58ee6f624546c5d2d
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A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

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