Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage...
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Nature Portfolio
2020
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oai:doaj.org-article:cb9d1b65978f4b9aba741090656d7d492021-12-02T17:40:29ZRecurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer10.1038/s41467-020-16765-w2041-1723https://doaj.org/article/cb9d1b65978f4b9aba741090656d7d492020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16765-whttps://doaj.org/toc/2041-1723The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage.Andrea StrakovaThomas J. NichollsAdrian Baez-OrtegaMáire Ní LeathlobhairAlexander T. SampsonKatherine HughesIsobelle A. G. BoltonKevin GoriJinhong WangIlona Airikkala-OtterJanice L. AllenKaren M. AllumClara L. ArnoldLeontine Bansse-IssaThinlay N. BhutiaJocelyn L. BissonKelli BlankCristóbal BriceñoArtemio Castillo DomrachevaAnne M. CorriganHugh R. CranJane T. CrawfordStephen M. CutterEric DavisKarina F. de CastroAndrigo B. De NardiAnna P. de VosLaura Delgadillo KeenanEdward M. DonelanAdela R. Espinoza HuertaIbikunle A. FaramadeMohammed FazilEleni FotopoulouSkye N. FrueanFanny Gallardo-ArrietaOlga GlebovaPagona G. GouletsouRodrigo F. Häfelin ManriqueJoaquim J. G. P. HenriquesRodrigo S. HortaNatalia IgnatenkoYaghouba KaneCathy KingDebbie KoenigAda KrupaSteven J. KruzeniskiMarta Lanza-PereaMihran LazyanAdriana M. Lopez QuintanaThibault LosfeltGabriele MarinoSimón Martínez CastañedaMayra F. Martínez-LópezBedan M. MasuruliMichael MeyerEdward J. MignecoBerna NakanwagiKarter B. NealWinifred NeunzigSally J. NixonAntonio Ortega-PachecoFrancisco Pedraza-OrdoñezMaria C. PeleteiroKatherine PolakRuth J. PyeJuan C. Ramirez-AnteJohn F. ReeceJose Rojas GutierrezHaleema SadiaSheila K. SchmelingOlga ShamanovaAlan G. SherlockAudrey E. Steenland-SmitAlla SvitichLester J. Tapia MartínezIsmail Thoya NgokaCristian G. TorresElizabeth M. TudorMirjam G. van der WelBogdan A. VițălaruSevil A. VuralOliver WalkintonAlvaro S. Wehrle-MartinezSophie A. E. WiddowsonIrina ZvarichPatrick F. ChinneryMaria FalkenbergClaes M. GustafssonElizabeth P. MurchisonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020) |
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DOAJ |
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EN |
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Science Q |
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Science Q Andrea Strakova Thomas J. Nicholls Adrian Baez-Ortega Máire Ní Leathlobhair Alexander T. Sampson Katherine Hughes Isobelle A. G. Bolton Kevin Gori Jinhong Wang Ilona Airikkala-Otter Janice L. Allen Karen M. Allum Clara L. Arnold Leontine Bansse-Issa Thinlay N. Bhutia Jocelyn L. Bisson Kelli Blank Cristóbal Briceño Artemio Castillo Domracheva Anne M. Corrigan Hugh R. Cran Jane T. Crawford Stephen M. Cutter Eric Davis Karina F. de Castro Andrigo B. De Nardi Anna P. de Vos Laura Delgadillo Keenan Edward M. Donelan Adela R. Espinoza Huerta Ibikunle A. Faramade Mohammed Fazil Eleni Fotopoulou Skye N. Fruean Fanny Gallardo-Arrieta Olga Glebova Pagona G. Gouletsou Rodrigo F. Häfelin Manrique Joaquim J. G. P. Henriques Rodrigo S. Horta Natalia Ignatenko Yaghouba Kane Cathy King Debbie Koenig Ada Krupa Steven J. Kruzeniski Marta Lanza-Perea Mihran Lazyan Adriana M. Lopez Quintana Thibault Losfelt Gabriele Marino Simón Martínez Castañeda Mayra F. Martínez-López Bedan M. Masuruli Michael Meyer Edward J. Migneco Berna Nakanwagi Karter B. Neal Winifred Neunzig Sally J. Nixon Antonio Ortega-Pacheco Francisco Pedraza-Ordoñez Maria C. Peleteiro Katherine Polak Ruth J. Pye Juan C. Ramirez-Ante John F. Reece Jose Rojas Gutierrez Haleema Sadia Sheila K. Schmeling Olga Shamanova Alan G. Sherlock Audrey E. Steenland-Smit Alla Svitich Lester J. Tapia Martínez Ismail Thoya Ngoka Cristian G. Torres Elizabeth M. Tudor Mirjam G. van der Wel Bogdan A. Vițălaru Sevil A. Vural Oliver Walkinton Alvaro S. Wehrle-Martinez Sophie A. E. Widdowson Irina Zvarich Patrick F. Chinnery Maria Falkenberg Claes M. Gustafsson Elizabeth P. Murchison Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| description |
The competitive dynamics of mitochondrial haplotypes juxtaposed within the same cell are poorly studied. Here the authors show, in the context of a transmissible cancer, that one haplotype has recurrently entered cancer cells by horizontal transfer and appears to have a ‘selfish’ selective advantage. |
| format |
article |
| author |
Andrea Strakova Thomas J. Nicholls Adrian Baez-Ortega Máire Ní Leathlobhair Alexander T. Sampson Katherine Hughes Isobelle A. G. Bolton Kevin Gori Jinhong Wang Ilona Airikkala-Otter Janice L. Allen Karen M. Allum Clara L. Arnold Leontine Bansse-Issa Thinlay N. Bhutia Jocelyn L. Bisson Kelli Blank Cristóbal Briceño Artemio Castillo Domracheva Anne M. Corrigan Hugh R. Cran Jane T. Crawford Stephen M. Cutter Eric Davis Karina F. de Castro Andrigo B. De Nardi Anna P. de Vos Laura Delgadillo Keenan Edward M. Donelan Adela R. Espinoza Huerta Ibikunle A. Faramade Mohammed Fazil Eleni Fotopoulou Skye N. Fruean Fanny Gallardo-Arrieta Olga Glebova Pagona G. Gouletsou Rodrigo F. Häfelin Manrique Joaquim J. G. P. Henriques Rodrigo S. Horta Natalia Ignatenko Yaghouba Kane Cathy King Debbie Koenig Ada Krupa Steven J. Kruzeniski Marta Lanza-Perea Mihran Lazyan Adriana M. Lopez Quintana Thibault Losfelt Gabriele Marino Simón Martínez Castañeda Mayra F. Martínez-López Bedan M. Masuruli Michael Meyer Edward J. Migneco Berna Nakanwagi Karter B. Neal Winifred Neunzig Sally J. Nixon Antonio Ortega-Pacheco Francisco Pedraza-Ordoñez Maria C. Peleteiro Katherine Polak Ruth J. Pye Juan C. Ramirez-Ante John F. Reece Jose Rojas Gutierrez Haleema Sadia Sheila K. Schmeling Olga Shamanova Alan G. Sherlock Audrey E. Steenland-Smit Alla Svitich Lester J. Tapia Martínez Ismail Thoya Ngoka Cristian G. Torres Elizabeth M. Tudor Mirjam G. van der Wel Bogdan A. Vițălaru Sevil A. Vural Oliver Walkinton Alvaro S. Wehrle-Martinez Sophie A. E. Widdowson Irina Zvarich Patrick F. Chinnery Maria Falkenberg Claes M. Gustafsson Elizabeth P. Murchison |
| author_facet |
Andrea Strakova Thomas J. Nicholls Adrian Baez-Ortega Máire Ní Leathlobhair Alexander T. Sampson Katherine Hughes Isobelle A. G. Bolton Kevin Gori Jinhong Wang Ilona Airikkala-Otter Janice L. Allen Karen M. Allum Clara L. Arnold Leontine Bansse-Issa Thinlay N. Bhutia Jocelyn L. Bisson Kelli Blank Cristóbal Briceño Artemio Castillo Domracheva Anne M. Corrigan Hugh R. Cran Jane T. Crawford Stephen M. Cutter Eric Davis Karina F. de Castro Andrigo B. De Nardi Anna P. de Vos Laura Delgadillo Keenan Edward M. Donelan Adela R. Espinoza Huerta Ibikunle A. Faramade Mohammed Fazil Eleni Fotopoulou Skye N. Fruean Fanny Gallardo-Arrieta Olga Glebova Pagona G. Gouletsou Rodrigo F. Häfelin Manrique Joaquim J. G. P. Henriques Rodrigo S. Horta Natalia Ignatenko Yaghouba Kane Cathy King Debbie Koenig Ada Krupa Steven J. Kruzeniski Marta Lanza-Perea Mihran Lazyan Adriana M. Lopez Quintana Thibault Losfelt Gabriele Marino Simón Martínez Castañeda Mayra F. Martínez-López Bedan M. Masuruli Michael Meyer Edward J. Migneco Berna Nakanwagi Karter B. Neal Winifred Neunzig Sally J. Nixon Antonio Ortega-Pacheco Francisco Pedraza-Ordoñez Maria C. Peleteiro Katherine Polak Ruth J. Pye Juan C. Ramirez-Ante John F. Reece Jose Rojas Gutierrez Haleema Sadia Sheila K. Schmeling Olga Shamanova Alan G. Sherlock Audrey E. Steenland-Smit Alla Svitich Lester J. Tapia Martínez Ismail Thoya Ngoka Cristian G. Torres Elizabeth M. Tudor Mirjam G. van der Wel Bogdan A. Vițălaru Sevil A. Vural Oliver Walkinton Alvaro S. Wehrle-Martinez Sophie A. E. Widdowson Irina Zvarich Patrick F. Chinnery Maria Falkenberg Claes M. Gustafsson Elizabeth P. Murchison |
| author_sort |
Andrea Strakova |
| title |
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_short |
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_full |
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_fullStr |
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_full_unstemmed |
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| title_sort |
recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/cb9d1b65978f4b9aba741090656d7d49 |
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