Phenome-wide association studies across large population cohorts support drug target validation
Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects....
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Nature Portfolio
2018
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oai:doaj.org-article:cb9fc601268446ca86cfc25a436b40c62021-12-02T15:33:58ZPhenome-wide association studies across large population cohorts support drug target validation10.1038/s41467-018-06540-32041-1723https://doaj.org/article/cb9fc601268446ca86cfc25a436b40c62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06540-3https://doaj.org/toc/2041-1723Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects.Dorothée DiogoChao TianChristopher S. FranklinMervi Alanne-KinnunenMichael MarchChris C. A. SpencerCiara VangjeliMichael E. WealeHannele MattssonElina KilpeläinenPatrick M. A. SleimanDermot F. ReillyJoshua McElweeJoseph C. MaranvilleArnaub K. ChatterjeeAman BhandariKhanh-Dung H. NguyenKarol EstradaMary-Pat ReeveJanna HutzNan BingSally JohnDaniel G. MacArthurVeikko SalomaaSamuli RipattiHakon HakonarsonMark J. DalyAarno PalotieDavid A. HindsPeter DonnellyCaroline S. FoxAaron G. Day-WilliamsRobert M. PlengeHeiko RunzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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DOAJ |
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EN |
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Science Q |
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Science Q Dorothée Diogo Chao Tian Christopher S. Franklin Mervi Alanne-Kinnunen Michael March Chris C. A. Spencer Ciara Vangjeli Michael E. Weale Hannele Mattsson Elina Kilpeläinen Patrick M. A. Sleiman Dermot F. Reilly Joshua McElwee Joseph C. Maranville Arnaub K. Chatterjee Aman Bhandari Khanh-Dung H. Nguyen Karol Estrada Mary-Pat Reeve Janna Hutz Nan Bing Sally John Daniel G. MacArthur Veikko Salomaa Samuli Ripatti Hakon Hakonarson Mark J. Daly Aarno Palotie David A. Hinds Peter Donnelly Caroline S. Fox Aaron G. Day-Williams Robert M. Plenge Heiko Runz Phenome-wide association studies across large population cohorts support drug target validation |
| description |
Testing the association between genetic variants and a range of phenotypes can assist drug development. Here, in a phenome-wide association study in up to 697,815 individuals, Diogo et al. identify genotype–phenotype associations predicting efficacy, alternative indications or adverse drug effects. |
| format |
article |
| author |
Dorothée Diogo Chao Tian Christopher S. Franklin Mervi Alanne-Kinnunen Michael March Chris C. A. Spencer Ciara Vangjeli Michael E. Weale Hannele Mattsson Elina Kilpeläinen Patrick M. A. Sleiman Dermot F. Reilly Joshua McElwee Joseph C. Maranville Arnaub K. Chatterjee Aman Bhandari Khanh-Dung H. Nguyen Karol Estrada Mary-Pat Reeve Janna Hutz Nan Bing Sally John Daniel G. MacArthur Veikko Salomaa Samuli Ripatti Hakon Hakonarson Mark J. Daly Aarno Palotie David A. Hinds Peter Donnelly Caroline S. Fox Aaron G. Day-Williams Robert M. Plenge Heiko Runz |
| author_facet |
Dorothée Diogo Chao Tian Christopher S. Franklin Mervi Alanne-Kinnunen Michael March Chris C. A. Spencer Ciara Vangjeli Michael E. Weale Hannele Mattsson Elina Kilpeläinen Patrick M. A. Sleiman Dermot F. Reilly Joshua McElwee Joseph C. Maranville Arnaub K. Chatterjee Aman Bhandari Khanh-Dung H. Nguyen Karol Estrada Mary-Pat Reeve Janna Hutz Nan Bing Sally John Daniel G. MacArthur Veikko Salomaa Samuli Ripatti Hakon Hakonarson Mark J. Daly Aarno Palotie David A. Hinds Peter Donnelly Caroline S. Fox Aaron G. Day-Williams Robert M. Plenge Heiko Runz |
| author_sort |
Dorothée Diogo |
| title |
Phenome-wide association studies across large population cohorts support drug target validation |
| title_short |
Phenome-wide association studies across large population cohorts support drug target validation |
| title_full |
Phenome-wide association studies across large population cohorts support drug target validation |
| title_fullStr |
Phenome-wide association studies across large population cohorts support drug target validation |
| title_full_unstemmed |
Phenome-wide association studies across large population cohorts support drug target validation |
| title_sort |
phenome-wide association studies across large population cohorts support drug target validation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/cb9fc601268446ca86cfc25a436b40c6 |
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