Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent...

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Autores principales:	Monika Ruszała, Magdalena Niebrzydowska, Aleksandra Pilszyk, Żaneta Kimber-Trojnar, Marcin Trojnar, Bożena Leszczyńska-Gorzelak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gestational diabetes mellitus biomolecules adipokines predictor Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/cba1c1f7aae1450ab77e6004b6a0db31
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spelling	oai:doaj.org-article:cba1c1f7aae1450ab77e6004b6a0db312021-11-11T17:03:45ZNovel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus10.3390/ijms2221115781422-00671661-6596https://doaj.org/article/cba1c1f7aae1450ab77e6004b6a0db312021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11578https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.Monika RuszałaMagdalena NiebrzydowskaAleksandra PilszykŻaneta Kimber-TrojnarMarcin TrojnarBożena Leszczyńska-GorzelakMDPI AGarticlegestational diabetes mellitusbiomoleculesadipokinespredictorBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11578, p 11578 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gestational diabetes mellitus biomolecules adipokines predictor Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	gestational diabetes mellitus biomolecules adipokines predictor Biology (General) QH301-705.5 Chemistry QD1-999 Monika Ruszała Magdalena Niebrzydowska Aleksandra Pilszyk Żaneta Kimber-Trojnar Marcin Trojnar Bożena Leszczyńska-Gorzelak Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
description	Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in pregnant women. Its early diagnosis seems to have a significant impact on the developing fetus, the course of delivery, and the neonatal period. It may also affect the later stages of child development and subsequent complications in the mother. Therefore, the crux of the matter is to find a biopredictor capable of singling out women at risk of developing GDM as early as the very start of pregnancy. Apart from the well-known molecules with a proven and clear-cut role in the pathogenesis of GDM, e.g., adiponectin and leptin, a potential role of newer biomolecules is also emphasized. Less popular and less known factors with different mechanisms of action include: galectins, growth differentiation factor-15, chemerin, omentin-1, osteocalcin, resistin, visfatin, vaspin, irisin, apelin, fatty acid-binding protein 4 (FABP4), fibroblast growth factor 21, and lipocalin-2. The aim of this review is to present the potential and significance of these 13 less known biomolecules in the pathogenesis of GDM. It seems that high levels of FABP4, low levels of irisin, and high levels of under-carboxylated osteocalcin in the serum of pregnant women can be used as predictive markers in the diagnosis of GDM. Hopefully, future clinical trials will be able to determine which biomolecules have the most potential to predict GDM.
format	article
author	Monika Ruszała Magdalena Niebrzydowska Aleksandra Pilszyk Żaneta Kimber-Trojnar Marcin Trojnar Bożena Leszczyńska-Gorzelak
author_facet	Monika Ruszała Magdalena Niebrzydowska Aleksandra Pilszyk Żaneta Kimber-Trojnar Marcin Trojnar Bożena Leszczyńska-Gorzelak
author_sort	Monika Ruszała
title	Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
title_short	Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
title_full	Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
title_fullStr	Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
title_full_unstemmed	Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus
title_sort	novel biomolecules in the pathogenesis of gestational diabetes mellitus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cba1c1f7aae1450ab77e6004b6a0db31
work_keys_str_mv	AT monikaruszała novelbiomoleculesinthepathogenesisofgestationaldiabetesmellitus AT magdalenaniebrzydowska novelbiomoleculesinthepathogenesisofgestationaldiabetesmellitus AT aleksandrapilszyk novelbiomoleculesinthepathogenesisofgestationaldiabetesmellitus AT zanetakimbertrojnar novelbiomoleculesinthepathogenesisofgestationaldiabetesmellitus AT marcintrojnar novelbiomoleculesinthepathogenesisofgestationaldiabetesmellitus AT bozenaleszczynskagorzelak novelbiomoleculesinthepathogenesisofgestationaldiabetesmellitus
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Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus

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