A gene network regulated by FGF signalling during ear development

Abstract During development cell commitment is regulated by inductive signals that are tightly controlled in time and space. In response, cells activate specific programmes, but the transcriptional circuits that maintain cell identity in a changing signalling environment are often poorly understood....

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Autores principales:	Maryam Anwar, Monica Tambalo, Ramya Ranganathan, Timothy Grocott, Andrea Streit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cba61df877024054b2447f69ece8ffe0
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spelling	oai:doaj.org-article:cba61df877024054b2447f69ece8ffe02021-12-02T12:31:52ZA gene network regulated by FGF signalling during ear development10.1038/s41598-017-05472-02045-2322https://doaj.org/article/cba61df877024054b2447f69ece8ffe02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05472-0https://doaj.org/toc/2045-2322Abstract During development cell commitment is regulated by inductive signals that are tightly controlled in time and space. In response, cells activate specific programmes, but the transcriptional circuits that maintain cell identity in a changing signalling environment are often poorly understood. Specification of inner ear progenitors is initiated by FGF signalling. Here, we establish the genetic hierarchy downstream of FGF by systematic analysis of many ear factors combined with a network inference approach. We show that FGF rapidly activates a small circuit of transcription factors forming positive feedback loops to stabilise otic progenitor identity. Our predictive network suggests that subsequently, transcriptional repressors ensure the transition of progenitors to mature otic cells, while simultaneously repressing alternative fates. Thus, we reveal the regulatory logic that initiates ear formation and highlight the hierarchical organisation of the otic gene network.Maryam AnwarMonica TambaloRamya RanganathanTimothy GrocottAndrea StreitNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maryam Anwar Monica Tambalo Ramya Ranganathan Timothy Grocott Andrea Streit A gene network regulated by FGF signalling during ear development
description	Abstract During development cell commitment is regulated by inductive signals that are tightly controlled in time and space. In response, cells activate specific programmes, but the transcriptional circuits that maintain cell identity in a changing signalling environment are often poorly understood. Specification of inner ear progenitors is initiated by FGF signalling. Here, we establish the genetic hierarchy downstream of FGF by systematic analysis of many ear factors combined with a network inference approach. We show that FGF rapidly activates a small circuit of transcription factors forming positive feedback loops to stabilise otic progenitor identity. Our predictive network suggests that subsequently, transcriptional repressors ensure the transition of progenitors to mature otic cells, while simultaneously repressing alternative fates. Thus, we reveal the regulatory logic that initiates ear formation and highlight the hierarchical organisation of the otic gene network.
format	article
author	Maryam Anwar Monica Tambalo Ramya Ranganathan Timothy Grocott Andrea Streit
author_facet	Maryam Anwar Monica Tambalo Ramya Ranganathan Timothy Grocott Andrea Streit
author_sort	Maryam Anwar
title	A gene network regulated by FGF signalling during ear development
title_short	A gene network regulated by FGF signalling during ear development
title_full	A gene network regulated by FGF signalling during ear development
title_fullStr	A gene network regulated by FGF signalling during ear development
title_full_unstemmed	A gene network regulated by FGF signalling during ear development
title_sort	gene network regulated by fgf signalling during ear development
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cba61df877024054b2447f69ece8ffe0
work_keys_str_mv	AT maryamanwar agenenetworkregulatedbyfgfsignallingduringeardevelopment AT monicatambalo agenenetworkregulatedbyfgfsignallingduringeardevelopment AT ramyaranganathan agenenetworkregulatedbyfgfsignallingduringeardevelopment AT timothygrocott agenenetworkregulatedbyfgfsignallingduringeardevelopment AT andreastreit agenenetworkregulatedbyfgfsignallingduringeardevelopment AT maryamanwar genenetworkregulatedbyfgfsignallingduringeardevelopment AT monicatambalo genenetworkregulatedbyfgfsignallingduringeardevelopment AT ramyaranganathan genenetworkregulatedbyfgfsignallingduringeardevelopment AT timothygrocott genenetworkregulatedbyfgfsignallingduringeardevelopment AT andreastreit genenetworkregulatedbyfgfsignallingduringeardevelopment
_version_	1718394242904096768

A gene network regulated by FGF signalling during ear development

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