Life times of metastable states guide regulatory signaling in transcriptional riboswitches

Riboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and k...

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Autores principales:	Christina Helmling, Dean-Paulos Klötzner, Florian Sochor, Rachel Anne Mooney, Anna Wacker, Robert Landick, Boris Fürtig, Alexander Heckel, Harald Schwalbe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cba69ad002cb4eff9de91d0845331311
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spelling	oai:doaj.org-article:cba69ad002cb4eff9de91d08453313112021-12-02T16:56:39ZLife times of metastable states guide regulatory signaling in transcriptional riboswitches10.1038/s41467-018-03375-w2041-1723https://doaj.org/article/cba69ad002cb4eff9de91d08453313112018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03375-whttps://doaj.org/toc/2041-1723Riboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and kinetic on- and off-rates of ligand binding.Christina HelmlingDean-Paulos KlötznerFlorian SochorRachel Anne MooneyAnna WackerRobert LandickBoris FürtigAlexander HeckelHarald SchwalbeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christina Helmling Dean-Paulos Klötzner Florian Sochor Rachel Anne Mooney Anna Wacker Robert Landick Boris Fürtig Alexander Heckel Harald Schwalbe Life times of metastable states guide regulatory signaling in transcriptional riboswitches
description	Riboswitches are RNA-based regulatory elements, which regulate downstream gene expression by binding of small molecular weight ligands. Here the authors demonstrate the molecular mechanism of a transcriptional riboswitch that integrates changes in transcription rates, metabolite concentration, and kinetic on- and off-rates of ligand binding.
format	article
author	Christina Helmling Dean-Paulos Klötzner Florian Sochor Rachel Anne Mooney Anna Wacker Robert Landick Boris Fürtig Alexander Heckel Harald Schwalbe
author_facet	Christina Helmling Dean-Paulos Klötzner Florian Sochor Rachel Anne Mooney Anna Wacker Robert Landick Boris Fürtig Alexander Heckel Harald Schwalbe
author_sort	Christina Helmling
title	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_short	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_full	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_fullStr	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_full_unstemmed	Life times of metastable states guide regulatory signaling in transcriptional riboswitches
title_sort	life times of metastable states guide regulatory signaling in transcriptional riboswitches
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cba69ad002cb4eff9de91d0845331311
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Life times of metastable states guide regulatory signaling in transcriptional riboswitches

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