Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu-Hsin Chiu, Christopher B. Medina, Catherine A. Doyle, Ming Zhou, Adishesh K. Narahari, Joanna K. Sandilos, Elizabeth C. Gonye, Hong-Yu Gao, Shih Yi Guo, Mahmut Parlak, Ulrike M. Lorenz, Thomas P. Conrads, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cbaa0bf914904995ab6ca9e837145a21
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cbaa0bf914904995ab6ca9e837145a21
record_format	dspace
spelling	oai:doaj.org-article:cbaa0bf914904995ab6ca9e837145a212021-12-02T17:56:56ZDeacetylation as a receptor-regulated direct activation switch for pannexin channels10.1038/s41467-021-24825-y2041-1723https://doaj.org/article/cbaa0bf914904995ab6ca9e837145a212021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24825-yhttps://doaj.org/toc/2041-1723Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1.Yu-Hsin ChiuChristopher B. MedinaCatherine A. DoyleMing ZhouAdishesh K. NarahariJoanna K. SandilosElizabeth C. GonyeHong-Yu GaoShih Yi GuoMahmut ParlakUlrike M. LorenzThomas P. ConradsBimal N. DesaiKodi S. RavichandranDouglas A. BaylissNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu-Hsin Chiu Christopher B. Medina Catherine A. Doyle Ming Zhou Adishesh K. Narahari Joanna K. Sandilos Elizabeth C. Gonye Hong-Yu Gao Shih Yi Guo Mahmut Parlak Ulrike M. Lorenz Thomas P. Conrads Bimal N. Desai Kodi S. Ravichandran Douglas A. Bayliss Deacetylation as a receptor-regulated direct activation switch for pannexin channels
description	Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1.
format	article
author	Yu-Hsin Chiu Christopher B. Medina Catherine A. Doyle Ming Zhou Adishesh K. Narahari Joanna K. Sandilos Elizabeth C. Gonye Hong-Yu Gao Shih Yi Guo Mahmut Parlak Ulrike M. Lorenz Thomas P. Conrads Bimal N. Desai Kodi S. Ravichandran Douglas A. Bayliss
author_facet	Yu-Hsin Chiu Christopher B. Medina Catherine A. Doyle Ming Zhou Adishesh K. Narahari Joanna K. Sandilos Elizabeth C. Gonye Hong-Yu Gao Shih Yi Guo Mahmut Parlak Ulrike M. Lorenz Thomas P. Conrads Bimal N. Desai Kodi S. Ravichandran Douglas A. Bayliss
author_sort	Yu-Hsin Chiu
title	Deacetylation as a receptor-regulated direct activation switch for pannexin channels
title_short	Deacetylation as a receptor-regulated direct activation switch for pannexin channels
title_full	Deacetylation as a receptor-regulated direct activation switch for pannexin channels
title_fullStr	Deacetylation as a receptor-regulated direct activation switch for pannexin channels
title_full_unstemmed	Deacetylation as a receptor-regulated direct activation switch for pannexin channels
title_sort	deacetylation as a receptor-regulated direct activation switch for pannexin channels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cbaa0bf914904995ab6ca9e837145a21
work_keys_str_mv	AT yuhsinchiu deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT christopherbmedina deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT catherineadoyle deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT mingzhou deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT adisheshknarahari deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT joannaksandilos deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT elizabethcgonye deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT hongyugao deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT shihyiguo deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT mahmutparlak deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT ulrikemlorenz deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT thomaspconrads deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT bimalndesai deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT kodisravichandran deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels AT douglasabayliss deacetylationasareceptorregulateddirectactivationswitchforpannexinchannels
_version_	1718379073007255552

Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Ejemplares similares