Deacetylation as a receptor-regulated direct activation switch for pannexin channels
Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves HDAC6- mediated lysine deacetylation of PANX1....
Guardado en:
Autores principales: | Yu-Hsin Chiu, Christopher B. Medina, Catherine A. Doyle, Ming Zhou, Adishesh K. Narahari, Joanna K. Sandilos, Elizabeth C. Gonye, Hong-Yu Gao, Shih Yi Guo, Mahmut Parlak, Ulrike M. Lorenz, Thomas P. Conrads, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/cbaa0bf914904995ab6ca9e837145a21 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A quantized mechanism for activation of pannexin channels
por: Yu-Hsin Chiu, et al.
Publicado: (2017) -
Pannexin 3 regulates skin development via Epiprofin
por: Peipei Zhang, et al.
Publicado: (2021) -
Deacetylation of Transcription Factors in Carcinogenesis
por: Marta Halasa, et al.
Publicado: (2021) -
The two faces of pannexins: new roles in inflammation and repair
por: Makarenkova HP, et al.
Publicado: (2018) -
Pannexin-1 channel opening is critical for COVID-19 pathogenesis
por: Ross Luu, et al.
Publicado: (2021)