PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance
Identifying novel therapies for the treatment of CDK4/6 inhibitor-resistant patients is of great importance. Here, the authors demonstrate that PLK1 inhibition is a potential therapeutic target in CCND1-driven and in RB-positive Palbociclib-resistant breast cancers.
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Nature Portfolio
2020
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oai:doaj.org-article:cbbadef41cb14a1b91639138a1f60fcb2021-12-02T19:06:29ZPLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance10.1038/s41467-020-17697-12041-1723https://doaj.org/article/cbbadef41cb14a1b91639138a1f60fcb2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17697-1https://doaj.org/toc/2041-1723Identifying novel therapies for the treatment of CDK4/6 inhibitor-resistant patients is of great importance. Here, the authors demonstrate that PLK1 inhibition is a potential therapeutic target in CCND1-driven and in RB-positive Palbociclib-resistant breast cancers.Elodie MontaudonJoanna Nikitorowicz-BuniakLaura SourdLudivine MorissetRania El BottyLéa HuguetAhmed DahmaniPierre PainsecFariba NematiSophie VacherWalid ChemlaliJulien Masliah-PlanchonSophie Château-JoubertCamilla RegaMariana Ferreira LealNikiana SimigdalaSunil PancholiRicardo RibasAndré NicolasDidier MeseureAnne Vincent-SalomonCécile ReyesAudrey RapinatDavid GentienThibaut LarcherMylène BohecSylvain BaulandeVirginie BernardDidier DecaudinFlorence CoussyMuriel Le RomancerGuillaume DutertreZakia TariqPaul CottuKeltouma DriouchIvan BiècheLesley-Ann MartinElisabetta MarangoniNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020) |
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DOAJ |
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Science Q Elodie Montaudon Joanna Nikitorowicz-Buniak Laura Sourd Ludivine Morisset Rania El Botty Léa Huguet Ahmed Dahmani Pierre Painsec Fariba Nemati Sophie Vacher Walid Chemlali Julien Masliah-Planchon Sophie Château-Joubert Camilla Rega Mariana Ferreira Leal Nikiana Simigdala Sunil Pancholi Ricardo Ribas André Nicolas Didier Meseure Anne Vincent-Salomon Cécile Reyes Audrey Rapinat David Gentien Thibaut Larcher Mylène Bohec Sylvain Baulande Virginie Bernard Didier Decaudin Florence Coussy Muriel Le Romancer Guillaume Dutertre Zakia Tariq Paul Cottu Keltouma Driouch Ivan Bièche Lesley-Ann Martin Elisabetta Marangoni PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance |
| description |
Identifying novel therapies for the treatment of CDK4/6 inhibitor-resistant patients is of great importance. Here, the authors demonstrate that PLK1 inhibition is a potential therapeutic target in CCND1-driven and in RB-positive Palbociclib-resistant breast cancers. |
| format |
article |
| author |
Elodie Montaudon Joanna Nikitorowicz-Buniak Laura Sourd Ludivine Morisset Rania El Botty Léa Huguet Ahmed Dahmani Pierre Painsec Fariba Nemati Sophie Vacher Walid Chemlali Julien Masliah-Planchon Sophie Château-Joubert Camilla Rega Mariana Ferreira Leal Nikiana Simigdala Sunil Pancholi Ricardo Ribas André Nicolas Didier Meseure Anne Vincent-Salomon Cécile Reyes Audrey Rapinat David Gentien Thibaut Larcher Mylène Bohec Sylvain Baulande Virginie Bernard Didier Decaudin Florence Coussy Muriel Le Romancer Guillaume Dutertre Zakia Tariq Paul Cottu Keltouma Driouch Ivan Bièche Lesley-Ann Martin Elisabetta Marangoni |
| author_facet |
Elodie Montaudon Joanna Nikitorowicz-Buniak Laura Sourd Ludivine Morisset Rania El Botty Léa Huguet Ahmed Dahmani Pierre Painsec Fariba Nemati Sophie Vacher Walid Chemlali Julien Masliah-Planchon Sophie Château-Joubert Camilla Rega Mariana Ferreira Leal Nikiana Simigdala Sunil Pancholi Ricardo Ribas André Nicolas Didier Meseure Anne Vincent-Salomon Cécile Reyes Audrey Rapinat David Gentien Thibaut Larcher Mylène Bohec Sylvain Baulande Virginie Bernard Didier Decaudin Florence Coussy Muriel Le Romancer Guillaume Dutertre Zakia Tariq Paul Cottu Keltouma Driouch Ivan Bièche Lesley-Ann Martin Elisabetta Marangoni |
| author_sort |
Elodie Montaudon |
| title |
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance |
| title_short |
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance |
| title_full |
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance |
| title_fullStr |
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance |
| title_full_unstemmed |
PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance |
| title_sort |
plk1 inhibition exhibits strong anti-tumoral activity in ccnd1-driven breast cancer metastases with acquired palbociclib resistance |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/cbbadef41cb14a1b91639138a1f60fcb |
| work_keys_str_mv |
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