CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema

CD4+ T cells are critical for the development of lymphedema. Here the authors show how these cells contribute to lymphedema and identify that the sphingosine-1-phosphate receptor modulator FTY720 can prevent lymphedema in a mouse tail injury model by blocking the release of CD4+ T cells from the lym...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gabriela D. García Nores, Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Geoffrey E. Hespe, Jeremy S. Torrisi, Jung Ju Huang, Jason C. Gardenier, Ira L. Savetsky, Matthew D. Nitti, Jessie Z. Yu, Sonia Rehal, Babak J. Mehrara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cbbc4761ee674a4bad5f425e2a34fa9d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cbbc4761ee674a4bad5f425e2a34fa9d
record_format	dspace
spelling	oai:doaj.org-article:cbbc4761ee674a4bad5f425e2a34fa9d2021-12-02T17:31:28ZCD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema10.1038/s41467-018-04418-y2041-1723https://doaj.org/article/cbbc4761ee674a4bad5f425e2a34fa9d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04418-yhttps://doaj.org/toc/2041-1723CD4+ T cells are critical for the development of lymphedema. Here the authors show how these cells contribute to lymphedema and identify that the sphingosine-1-phosphate receptor modulator FTY720 can prevent lymphedema in a mouse tail injury model by blocking the release of CD4+ T cells from the lymph nodes to the skin.Gabriela D. García NoresCatherine L. LyDaniel A. CuzzoneRaghu P. KataruGeoffrey E. HespeJeremy S. TorrisiJung Ju HuangJason C. GardenierIra L. SavetskyMatthew D. NittiJessie Z. YuSonia RehalBabak J. MehraraNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriela D. García Nores Catherine L. Ly Daniel A. Cuzzone Raghu P. Kataru Geoffrey E. Hespe Jeremy S. Torrisi Jung Ju Huang Jason C. Gardenier Ira L. Savetsky Matthew D. Nitti Jessie Z. Yu Sonia Rehal Babak J. Mehrara CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
description	CD4+ T cells are critical for the development of lymphedema. Here the authors show how these cells contribute to lymphedema and identify that the sphingosine-1-phosphate receptor modulator FTY720 can prevent lymphedema in a mouse tail injury model by blocking the release of CD4+ T cells from the lymph nodes to the skin.
format	article
author	Gabriela D. García Nores Catherine L. Ly Daniel A. Cuzzone Raghu P. Kataru Geoffrey E. Hespe Jeremy S. Torrisi Jung Ju Huang Jason C. Gardenier Ira L. Savetsky Matthew D. Nitti Jessie Z. Yu Sonia Rehal Babak J. Mehrara
author_facet	Gabriela D. García Nores Catherine L. Ly Daniel A. Cuzzone Raghu P. Kataru Geoffrey E. Hespe Jeremy S. Torrisi Jung Ju Huang Jason C. Gardenier Ira L. Savetsky Matthew D. Nitti Jessie Z. Yu Sonia Rehal Babak J. Mehrara
author_sort	Gabriela D. García Nores
title	CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
title_short	CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
title_full	CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
title_fullStr	CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
title_full_unstemmed	CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
title_sort	cd4+ t cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cbbc4761ee674a4bad5f425e2a34fa9d
work_keys_str_mv	AT gabrieladgarcianores cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT catherinelly cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT danielacuzzone cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT raghupkataru cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT geoffreyehespe cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT jeremystorrisi cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT jungjuhuang cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT jasoncgardenier cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT iralsavetsky cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT matthewdnitti cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT jessiezyu cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT soniarehal cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema AT babakjmehrara cd4tcellsareactivatedinregionallymphnodesandmigratetoskintoinitiatelymphedema
_version_	1718380639762251776

CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema

Ejemplares similares