Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers

Background: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of “immune memory” of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amou...

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Autores principales:	Marta Kasprowicz-Furmańczyk, Joanna Czerwińska, Waldemar Placek, Agnieszka Owczarczyk-Saczonek
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psoriasis tissue resident memory cells TRM immune memory Medicine R
Acceso en línea:	https://doaj.org/article/cbbd5b81f7be42ac93538617e00da2cf
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spelling	oai:doaj.org-article:cbbd5b81f7be42ac93538617e00da2cf2021-11-11T16:23:56ZAssessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers10.3390/ijerph1821112511660-46011661-7827https://doaj.org/article/cbbd5b81f7be42ac93538617e00da2cf2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11251https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Background: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of “immune memory” of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amount of TRM in psoriatic lesions in patients suffering from plaque psoriasis, as well as an analysis of the relationship between TRM markers expression and the duration and severity of the disease. Methods: TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17, IL-22) in the lesional psoriatic skin of 32 patients compared with 10 healthy skin samples were evaluated by immunohistochemistry. Results: The presence of TRM markers in both the epidermis and skin with psoriatic eruptions was demonstrated in much higher amounts compared with the skin of healthy volunteers. A significant positive relationship was demonstrated between the expression of TRM markers in patients with plaque psoriasis and the duration of skin lesions. There was no relationship between the amount of TRM and the severity of plaque psoriasis. Conclusions: A thorough understanding of the mechanisms responsible for the development and relapse of plaque psoriasis may contribute to the implementation of more effective therapies.Marta Kasprowicz-FurmańczykJoanna CzerwińskaWaldemar PlacekAgnieszka Owczarczyk-SaczonekMDPI AGarticlepsoriasistissue resident memory cellsTRMimmune memoryMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11251, p 11251 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis tissue resident memory cells TRM immune memory Medicine R
spellingShingle	psoriasis tissue resident memory cells TRM immune memory Medicine R Marta Kasprowicz-Furmańczyk Joanna Czerwińska Waldemar Placek Agnieszka Owczarczyk-Saczonek Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
description	Background: In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of “immune memory” of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amount of TRM in psoriatic lesions in patients suffering from plaque psoriasis, as well as an analysis of the relationship between TRM markers expression and the duration and severity of the disease. Methods: TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17, IL-22) in the lesional psoriatic skin of 32 patients compared with 10 healthy skin samples were evaluated by immunohistochemistry. Results: The presence of TRM markers in both the epidermis and skin with psoriatic eruptions was demonstrated in much higher amounts compared with the skin of healthy volunteers. A significant positive relationship was demonstrated between the expression of TRM markers in patients with plaque psoriasis and the duration of skin lesions. There was no relationship between the amount of TRM and the severity of plaque psoriasis. Conclusions: A thorough understanding of the mechanisms responsible for the development and relapse of plaque psoriasis may contribute to the implementation of more effective therapies.
format	article
author	Marta Kasprowicz-Furmańczyk Joanna Czerwińska Waldemar Placek Agnieszka Owczarczyk-Saczonek
author_facet	Marta Kasprowicz-Furmańczyk Joanna Czerwińska Waldemar Placek Agnieszka Owczarczyk-Saczonek
author_sort	Marta Kasprowicz-Furmańczyk
title	Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
title_short	Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
title_full	Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
title_fullStr	Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
title_full_unstemmed	Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers
title_sort	assessment of the tissue resident memory cells in lesional skin of patients with psoriasis and in healthy skin of healthy volunteers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cbbd5b81f7be42ac93538617e00da2cf
work_keys_str_mv	AT martakasprowiczfurmanczyk assessmentofthetissueresidentmemorycellsinlesionalskinofpatientswithpsoriasisandinhealthyskinofhealthyvolunteers AT joannaczerwinska assessmentofthetissueresidentmemorycellsinlesionalskinofpatientswithpsoriasisandinhealthyskinofhealthyvolunteers AT waldemarplacek assessmentofthetissueresidentmemorycellsinlesionalskinofpatientswithpsoriasisandinhealthyskinofhealthyvolunteers AT agnieszkaowczarczyksaczonek assessmentofthetissueresidentmemorycellsinlesionalskinofpatientswithpsoriasisandinhealthyskinofhealthyvolunteers
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Assessment of the Tissue Resident Memory Cells in Lesional Skin of Patients with Psoriasis and in Healthy Skin of Healthy Volunteers

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