The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study

The association between polycystic ovary syndrome (PCOS) and endometrial cancer remains unclear. We aimed to investigate the causal association between genetically predicted PCOS and endometrial cancer risk in two ethnic groups through a two-sample Mendelian randomization (MR) approach. Our study in...

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Autores principales:	Hanxiao Chen, Yaoyao Zhang, Shangwei Li, Yuanzhi Tao, Rui Gao, Wenming Xu, Yihong Yang, Kemin Cheng, Yan Wang, Lang Qin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	polycystic ovary syndrome endometrial cancer Mendelian randomization GWAS SNP Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/cbc725081b8e4f738d6b42146de31a99
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spelling	oai:doaj.org-article:cbc725081b8e4f738d6b42146de31a992021-11-05T14:52:29ZThe Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study1664-239210.3389/fendo.2021.756137https://doaj.org/article/cbc725081b8e4f738d6b42146de31a992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.756137/fullhttps://doaj.org/toc/1664-2392The association between polycystic ovary syndrome (PCOS) and endometrial cancer remains unclear. We aimed to investigate the causal association between genetically predicted PCOS and endometrial cancer risk in two ethnic groups through a two-sample Mendelian randomization (MR) approach. Our study includes 13 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for PCOS in Europeans, and another 13 SNPs are used as IVs for PCOS in Asians. Outcome data were obtained from the largest published meta-GWAS of European ancestry to date, as well as from the BioBank Japan Project of Asian ancestry. Our study demonstrates that genetically predicted PCOS is not causally associated with the risk of overall endometrial cancer in either Europeans or Asians (odds ratio (OR) = 0.93, 95% confidence interval (CI) = 0.85–1.01, p = 0.09 and OR = 0.98, 95% CI 0.84–1.13, p = 0.75, respectively). Subgroup analyses according to histotype further illustrate that PCOS might not be associated with the risk of either endometrioid endometrial cancer or non-endometrioid endometrial cancer in European ancestry. No pleiotropy is found in our study, and a sensitivity analysis shows similar results. Our results indicate that genetically predicted PCOS might not be associated with the risk of endometrial cancer.Hanxiao ChenHanxiao ChenHanxiao ChenYaoyao ZhangYaoyao ZhangShangwei LiShangwei LiYuanzhi TaoYuanzhi TaoRui GaoRui GaoWenming XuWenming XuYihong YangYihong YangKemin ChengYan WangLang QinLang QinFrontiers Media S.A.articlepolycystic ovary syndromeendometrial cancerMendelian randomizationGWASSNPDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polycystic ovary syndrome endometrial cancer Mendelian randomization GWAS SNP Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	polycystic ovary syndrome endometrial cancer Mendelian randomization GWAS SNP Diseases of the endocrine glands. Clinical endocrinology RC648-665 Hanxiao Chen Hanxiao Chen Hanxiao Chen Yaoyao Zhang Yaoyao Zhang Shangwei Li Shangwei Li Yuanzhi Tao Yuanzhi Tao Rui Gao Rui Gao Wenming Xu Wenming Xu Yihong Yang Yihong Yang Kemin Cheng Yan Wang Lang Qin Lang Qin The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study
description	The association between polycystic ovary syndrome (PCOS) and endometrial cancer remains unclear. We aimed to investigate the causal association between genetically predicted PCOS and endometrial cancer risk in two ethnic groups through a two-sample Mendelian randomization (MR) approach. Our study includes 13 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for PCOS in Europeans, and another 13 SNPs are used as IVs for PCOS in Asians. Outcome data were obtained from the largest published meta-GWAS of European ancestry to date, as well as from the BioBank Japan Project of Asian ancestry. Our study demonstrates that genetically predicted PCOS is not causally associated with the risk of overall endometrial cancer in either Europeans or Asians (odds ratio (OR) = 0.93, 95% confidence interval (CI) = 0.85–1.01, p = 0.09 and OR = 0.98, 95% CI 0.84–1.13, p = 0.75, respectively). Subgroup analyses according to histotype further illustrate that PCOS might not be associated with the risk of either endometrioid endometrial cancer or non-endometrioid endometrial cancer in European ancestry. No pleiotropy is found in our study, and a sensitivity analysis shows similar results. Our results indicate that genetically predicted PCOS might not be associated with the risk of endometrial cancer.
format	article
author	Hanxiao Chen Hanxiao Chen Hanxiao Chen Yaoyao Zhang Yaoyao Zhang Shangwei Li Shangwei Li Yuanzhi Tao Yuanzhi Tao Rui Gao Rui Gao Wenming Xu Wenming Xu Yihong Yang Yihong Yang Kemin Cheng Yan Wang Lang Qin Lang Qin
author_facet	Hanxiao Chen Hanxiao Chen Hanxiao Chen Yaoyao Zhang Yaoyao Zhang Shangwei Li Shangwei Li Yuanzhi Tao Yuanzhi Tao Rui Gao Rui Gao Wenming Xu Wenming Xu Yihong Yang Yihong Yang Kemin Cheng Yan Wang Lang Qin Lang Qin
author_sort	Hanxiao Chen
title	The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study
title_short	The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study
title_full	The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study
title_fullStr	The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study
title_full_unstemmed	The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study
title_sort	genetic association of polycystic ovary syndrome and the risk of endometrial cancer: a mendelian randomization study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cbc725081b8e4f738d6b42146de31a99
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The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study

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