Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis
Naotaka Murata,1 Hideaki Aihara,2 Yoshimitsu Soga,1 Yusuke Tomoi,1 Seiichi Hiramori,1 Yohei Kobayashi,1 Kei Ichihashi,1 Nobuhiro Tanaka3 1Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, 2Department of Cardiology, Tsukuba Medical Center Hospital, Ibaraki, 3Department of Cardiology, To...
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Dove Medical Press
2015
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oai:doaj.org-article:cbcb967c258e40e8b51183dc78498d5d2021-12-02T04:55:59ZValidation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis1179-1470https://doaj.org/article/cbcb967c258e40e8b51183dc78498d5d2015-11-01T00:00:00Zhttps://www.dovepress.com/validation-of-pressure-gradient-and-peripheral-fractional-flow-reserve-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Naotaka Murata,1 Hideaki Aihara,2 Yoshimitsu Soga,1 Yusuke Tomoi,1 Seiichi Hiramori,1 Yohei Kobayashi,1 Kei Ichihashi,1 Nobuhiro Tanaka3 1Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, 2Department of Cardiology, Tsukuba Medical Center Hospital, Ibaraki, 3Department of Cardiology, Tokyo Medical University, Tokyo, Japan Objective: To examine the pressure gradient and peripheral fractional flow reserve (pFFR) measured by a pressure wire as indicators of hemodynamic significance in iliofemoral angiographic intermediate stenosis. Background: The utility of pressure measurements using a pressure wire with vasodilators is unclear in cases with intermediate iliofemoral stenosis. Methods: The mean pressure gradient (MPG) and mean pressure ratio (MPR) were measured at baseline and after injection of isosorbide dinitrate in 23 lesions with angiographically intermediate iliofemoral stenosis. Patients with complex lesions, infrapopliteal artery lesions, chronic total occlusion, and surgical bypass grafts were excluded. Hyperemic MPR was considered equivalent to pFFR. Changes in parameters in response to vasodilators were assessed and correlations of peak systolic velocity ratio (PSVR) with hyperemic MPG and pFFR were examined using duplex ultrasound. Results: After injection of isosorbide dinitrate, hyperemic MPG increased significantly (from 9.0±5.7 to 16.3±6.2 mmHg; P<0.05) and hyperemic MPR (pFFR) decreased significantly (from 0.92±0.06 to 0.81±0.07; P<0.05). PSVR was significantly correlated with hyperemic MPG (R=0.52; P<0.05) and pFFR (R=–0.50; P<0.05). The optimal cut-off value of pFFR as an indicator of significant hemodynamic stenosis (PSVR >2.5) was 0.85 (area under the curve 0.72; sensitivity 94%; specificity 50%, P<0.05). Conclusion: pFFR measured using a pressure wire is reliable for prediction of hemodynamic significance in iliofemoral intermediate stenosis. Keywords: endovascular therapy, peripheral artery disease, pressure measurements, hyperemia, vasodilators, hemodynamics Murata NAihara HSoga YTomoi YHiramori SKobayashi YIchihashi KTanaka NDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2015, Iss default, Pp 467-472 (2015) |
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Medical technology R855-855.5 |
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Medical technology R855-855.5 Murata N Aihara H Soga Y Tomoi Y Hiramori S Kobayashi Y Ichihashi K Tanaka N Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| description |
Naotaka Murata,1 Hideaki Aihara,2 Yoshimitsu Soga,1 Yusuke Tomoi,1 Seiichi Hiramori,1 Yohei Kobayashi,1 Kei Ichihashi,1 Nobuhiro Tanaka3 1Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, 2Department of Cardiology, Tsukuba Medical Center Hospital, Ibaraki, 3Department of Cardiology, Tokyo Medical University, Tokyo, Japan Objective: To examine the pressure gradient and peripheral fractional flow reserve (pFFR) measured by a pressure wire as indicators of hemodynamic significance in iliofemoral angiographic intermediate stenosis. Background: The utility of pressure measurements using a pressure wire with vasodilators is unclear in cases with intermediate iliofemoral stenosis. Methods: The mean pressure gradient (MPG) and mean pressure ratio (MPR) were measured at baseline and after injection of isosorbide dinitrate in 23 lesions with angiographically intermediate iliofemoral stenosis. Patients with complex lesions, infrapopliteal artery lesions, chronic total occlusion, and surgical bypass grafts were excluded. Hyperemic MPR was considered equivalent to pFFR. Changes in parameters in response to vasodilators were assessed and correlations of peak systolic velocity ratio (PSVR) with hyperemic MPG and pFFR were examined using duplex ultrasound. Results: After injection of isosorbide dinitrate, hyperemic MPG increased significantly (from 9.0±5.7 to 16.3±6.2 mmHg; P<0.05) and hyperemic MPR (pFFR) decreased significantly (from 0.92±0.06 to 0.81±0.07; P<0.05). PSVR was significantly correlated with hyperemic MPG (R=0.52; P<0.05) and pFFR (R=–0.50; P<0.05). The optimal cut-off value of pFFR as an indicator of significant hemodynamic stenosis (PSVR >2.5) was 0.85 (area under the curve 0.72; sensitivity 94%; specificity 50%, P<0.05). Conclusion: pFFR measured using a pressure wire is reliable for prediction of hemodynamic significance in iliofemoral intermediate stenosis. Keywords: endovascular therapy, peripheral artery disease, pressure measurements, hyperemia, vasodilators, hemodynamics |
| format |
article |
| author |
Murata N Aihara H Soga Y Tomoi Y Hiramori S Kobayashi Y Ichihashi K Tanaka N |
| author_facet |
Murata N Aihara H Soga Y Tomoi Y Hiramori S Kobayashi Y Ichihashi K Tanaka N |
| author_sort |
Murata N |
| title |
Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| title_short |
Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| title_full |
Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| title_fullStr |
Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| title_full_unstemmed |
Validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| title_sort |
validation of pressure gradient and peripheral fractional flow reserve measured by a pressure wire for diagnosis of iliofemoral artery disease with intermediate stenosis |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/cbcb967c258e40e8b51183dc78498d5d |
| work_keys_str_mv |
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