Cerebrocortical beta activity in overweight humans responds to insulin detemir.

<h4>Background</h4>Insulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance. In the present study we tested whether insulin detemir is a suitable tool to restore the cerebral insul...

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Autores principales:	Otto Tschritter, Anita M Hennige, Hubert Preissl, Katarina Porubska, Silke A Schäfer, Werner Lutzenberger, Fausto Machicao, Niels Birbaumer, Andreas Fritsche, Hans-Ulrich Häring
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cbcc3c0a878e410793d5b251f16ec508
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spelling	oai:doaj.org-article:cbcc3c0a878e410793d5b251f16ec5082021-11-25T06:13:51ZCerebrocortical beta activity in overweight humans responds to insulin detemir.1932-620310.1371/journal.pone.0001196https://doaj.org/article/cbcc3c0a878e410793d5b251f16ec5082007-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0001196https://doaj.org/toc/1932-6203<h4>Background</h4>Insulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance. In the present study we tested whether insulin detemir is a suitable tool to restore the cerebral insulin response in overweight humans. This approach is based on studies in mice where we could recently demonstrate increased brain tissue concentrations of insulin and increased insulin signaling in the hypothalamus and cerebral cortex following peripheral injection of insulin detemir.<h4>Methodology/principal findings</h4>We studied activity of the cerebral cortex using magnetoencephalography in 12 lean and 34 overweight non-diabetic humans during a 2-step hyperinsulinemic euglycemic clamp (each step 90 min) with human insulin (HI) and saline infusion (S). In 10 overweight subjects we additionally performed the euglycemic clamp with insulin detemir (D). While human insulin administration did not change cerebrocortical activity relative to saline (p = 0.90) in overweight subjects, beta activity increased during D administration (basal 59+/-3 fT, 1(st) step 62+/-3 fT, 2(nd) step 66+/-5, p = 0.001, D vs. HI). As under this condition glucose infusion rates were lower with D than with HI (p = 0.003), it can be excluded that the cerebral effect is the consequence of a systemic effect. The total effect of insulin detemir on beta activity was not different from the human insulin effect in lean subjects (p = 0.78).<h4>Conclusions/significance</h4>Despite cerebrocortical resistance to human insulin, insulin detemir increased beta activity in overweight human subjects similarly as human insulin in lean subjects. These data suggest that the decreased cerebral beta activity response in overweight subjects can be restored by insulin detemir.Otto TschritterAnita M HennigeHubert PreisslKatarina PorubskaSilke A SchäferWerner LutzenbergerFausto MachicaoNiels BirbaumerAndreas FritscheHans-Ulrich HäringPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 2, Iss 11, p e1196 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Otto Tschritter Anita M Hennige Hubert Preissl Katarina Porubska Silke A Schäfer Werner Lutzenberger Fausto Machicao Niels Birbaumer Andreas Fritsche Hans-Ulrich Häring Cerebrocortical beta activity in overweight humans responds to insulin detemir.
description	<h4>Background</h4>Insulin stimulates cerebrocortical beta and theta activity in lean humans. This effect is reduced in obese individuals indicating cerebrocortical insulin resistance. In the present study we tested whether insulin detemir is a suitable tool to restore the cerebral insulin response in overweight humans. This approach is based on studies in mice where we could recently demonstrate increased brain tissue concentrations of insulin and increased insulin signaling in the hypothalamus and cerebral cortex following peripheral injection of insulin detemir.<h4>Methodology/principal findings</h4>We studied activity of the cerebral cortex using magnetoencephalography in 12 lean and 34 overweight non-diabetic humans during a 2-step hyperinsulinemic euglycemic clamp (each step 90 min) with human insulin (HI) and saline infusion (S). In 10 overweight subjects we additionally performed the euglycemic clamp with insulin detemir (D). While human insulin administration did not change cerebrocortical activity relative to saline (p = 0.90) in overweight subjects, beta activity increased during D administration (basal 59+/-3 fT, 1(st) step 62+/-3 fT, 2(nd) step 66+/-5, p = 0.001, D vs. HI). As under this condition glucose infusion rates were lower with D than with HI (p = 0.003), it can be excluded that the cerebral effect is the consequence of a systemic effect. The total effect of insulin detemir on beta activity was not different from the human insulin effect in lean subjects (p = 0.78).<h4>Conclusions/significance</h4>Despite cerebrocortical resistance to human insulin, insulin detemir increased beta activity in overweight human subjects similarly as human insulin in lean subjects. These data suggest that the decreased cerebral beta activity response in overweight subjects can be restored by insulin detemir.
format	article
author	Otto Tschritter Anita M Hennige Hubert Preissl Katarina Porubska Silke A Schäfer Werner Lutzenberger Fausto Machicao Niels Birbaumer Andreas Fritsche Hans-Ulrich Häring
author_facet	Otto Tschritter Anita M Hennige Hubert Preissl Katarina Porubska Silke A Schäfer Werner Lutzenberger Fausto Machicao Niels Birbaumer Andreas Fritsche Hans-Ulrich Häring
author_sort	Otto Tschritter
title	Cerebrocortical beta activity in overweight humans responds to insulin detemir.
title_short	Cerebrocortical beta activity in overweight humans responds to insulin detemir.
title_full	Cerebrocortical beta activity in overweight humans responds to insulin detemir.
title_fullStr	Cerebrocortical beta activity in overweight humans responds to insulin detemir.
title_full_unstemmed	Cerebrocortical beta activity in overweight humans responds to insulin detemir.
title_sort	cerebrocortical beta activity in overweight humans responds to insulin detemir.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/cbcc3c0a878e410793d5b251f16ec508
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Cerebrocortical beta activity in overweight humans responds to insulin detemir.

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