Neural correlates of alerting and orienting impairment in multiple sclerosis patients.

<h4>Background</h4>A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this tes...

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Autores principales:	Manuel Vázquez-Marrufo, Alejandro Galvao-Carmona, Javier J González-Rosa, Antonio R Hidalgo-Muñoz, Mónica Borges, Juan Luis Ruiz-Peña, Guillermo Izquierdo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cbcddef1accb42a4b92faa70574e97d1
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spelling	oai:doaj.org-article:cbcddef1accb42a4b92faa70574e97d12021-11-18T08:19:41ZNeural correlates of alerting and orienting impairment in multiple sclerosis patients.1932-620310.1371/journal.pone.0097226https://doaj.org/article/cbcddef1accb42a4b92faa70574e97d12014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24820333/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test.<h4>Results</h4>After general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude).<h4>Conclusions</h4>Behavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients.Manuel Vázquez-MarrufoAlejandro Galvao-CarmonaJavier J González-RosaAntonio R Hidalgo-MuñozMónica BorgesJuan Luis Ruiz-PeñaGuillermo IzquierdoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97226 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manuel Vázquez-Marrufo Alejandro Galvao-Carmona Javier J González-Rosa Antonio R Hidalgo-Muñoz Mónica Borges Juan Luis Ruiz-Peña Guillermo Izquierdo Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
description	<h4>Background</h4>A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test.<h4>Results</h4>After general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude).<h4>Conclusions</h4>Behavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients.
format	article
author	Manuel Vázquez-Marrufo Alejandro Galvao-Carmona Javier J González-Rosa Antonio R Hidalgo-Muñoz Mónica Borges Juan Luis Ruiz-Peña Guillermo Izquierdo
author_facet	Manuel Vázquez-Marrufo Alejandro Galvao-Carmona Javier J González-Rosa Antonio R Hidalgo-Muñoz Mónica Borges Juan Luis Ruiz-Peña Guillermo Izquierdo
author_sort	Manuel Vázquez-Marrufo
title	Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
title_short	Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
title_full	Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
title_fullStr	Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
title_full_unstemmed	Neural correlates of alerting and orienting impairment in multiple sclerosis patients.
title_sort	neural correlates of alerting and orienting impairment in multiple sclerosis patients.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/cbcddef1accb42a4b92faa70574e97d1
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Neural correlates of alerting and orienting impairment in multiple sclerosis patients.

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