Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis

Abstract Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs modulation. Recent studies demonstrated...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fu Peng, Hailin Tang, Peng Liu, Jiangang Shen, Xinyuan Guan, Xiaofang Xie, Jihai Gao, Liang Xiong, Lei Jia, Jianping Chen, Cheng Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cbd7dca5bb244ff581355a22a01d6f85
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cbd7dca5bb244ff581355a22a01d6f85
record_format	dspace
spelling	oai:doaj.org-article:cbd7dca5bb244ff581355a22a01d6f852021-12-02T16:06:43ZIsoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis10.1038/s41598-017-08422-y2045-2322https://doaj.org/article/cbd7dca5bb244ff581355a22a01d6f852017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08422-yhttps://doaj.org/toc/2045-2322Abstract Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs modulation. Recent studies demonstrated that isoliquiritigenin could inhibit breast cancer cells proliferation and migration, but the underlying mechanism is still limited. In this study, the anti-cancer effects as well as the detailed mechanisms of isoliquiritigenin were explored. The results proved that isoliquiritigenin could negatively regulate breast cancer growth through the induction of apoptosis. We also verified the anti-cancer effect of isoliquiritigenin on migration and invasion, and identified highly expressed miR-374a as one of the main microRNAs down-regulated by isoliquiritigenin treatment in breast cancer. Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling. Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.Fu PengHailin TangPeng LiuJiangang ShenXinyuan GuanXiaofang XieJihai GaoLiang XiongLei JiaJianping ChenCheng PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fu Peng Hailin Tang Peng Liu Jiangang Shen Xinyuan Guan Xiaofang Xie Jihai Gao Liang Xiong Lei Jia Jianping Chen Cheng Peng Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
description	Abstract Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs modulation. Recent studies demonstrated that isoliquiritigenin could inhibit breast cancer cells proliferation and migration, but the underlying mechanism is still limited. In this study, the anti-cancer effects as well as the detailed mechanisms of isoliquiritigenin were explored. The results proved that isoliquiritigenin could negatively regulate breast cancer growth through the induction of apoptosis. We also verified the anti-cancer effect of isoliquiritigenin on migration and invasion, and identified highly expressed miR-374a as one of the main microRNAs down-regulated by isoliquiritigenin treatment in breast cancer. Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling. Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.
format	article
author	Fu Peng Hailin Tang Peng Liu Jiangang Shen Xinyuan Guan Xiaofang Xie Jihai Gao Liang Xiong Lei Jia Jianping Chen Cheng Peng
author_facet	Fu Peng Hailin Tang Peng Liu Jiangang Shen Xinyuan Guan Xiaofang Xie Jihai Gao Liang Xiong Lei Jia Jianping Chen Cheng Peng
author_sort	Fu Peng
title	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_short	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_full	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_fullStr	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_full_unstemmed	Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_sort	isoliquiritigenin modulates mir-374a/pten/akt axis to suppress breast cancer tumorigenesis and metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cbd7dca5bb244ff581355a22a01d6f85
work_keys_str_mv	AT fupeng isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT hailintang isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT pengliu isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT jiangangshen isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT xinyuanguan isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT xiaofangxie isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT jihaigao isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT liangxiong isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT leijia isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT jianpingchen isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis AT chengpeng isoliquiritigeninmodulatesmir374aptenaktaxistosuppressbreastcancertumorigenesisandmetastasis
_version_	1718384931957112832

Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis

Ejemplares similares