Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis

Abstract Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs modulation. Recent studies demonstrated...

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Autores principales: Fu Peng, Hailin Tang, Peng Liu, Jiangang Shen, Xinyuan Guan, Xiaofang Xie, Jihai Gao, Liang Xiong, Lei Jia, Jianping Chen, Cheng Peng
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/cbd7dca5bb244ff581355a22a01d6f85
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spelling oai:doaj.org-article:cbd7dca5bb244ff581355a22a01d6f852021-12-02T16:06:43ZIsoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis10.1038/s41598-017-08422-y2045-2322https://doaj.org/article/cbd7dca5bb244ff581355a22a01d6f852017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08422-yhttps://doaj.org/toc/2045-2322Abstract Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs modulation. Recent studies demonstrated that isoliquiritigenin could inhibit breast cancer cells proliferation and migration, but the underlying mechanism is still limited. In this study, the anti-cancer effects as well as the detailed mechanisms of isoliquiritigenin were explored. The results proved that isoliquiritigenin could negatively regulate breast cancer growth through the induction of apoptosis. We also verified the anti-cancer effect of isoliquiritigenin on migration and invasion, and identified highly expressed miR-374a as one of the main microRNAs down-regulated by isoliquiritigenin treatment in breast cancer. Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling. Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.Fu PengHailin TangPeng LiuJiangang ShenXinyuan GuanXiaofang XieJihai GaoLiang XiongLei JiaJianping ChenCheng PengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Fu Peng
Hailin Tang
Peng Liu
Jiangang Shen
Xinyuan Guan
Xiaofang Xie
Jihai Gao
Liang Xiong
Lei Jia
Jianping Chen
Cheng Peng
Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
description Abstract Breast cancer is one of the most frightful causes of death among females worldwide. Accumulating evidence attached the importance of microRNAs negative regulation to tumorigenesis in breast cancer, suggesting novel cancer therapies targeting microRNAs modulation. Recent studies demonstrated that isoliquiritigenin could inhibit breast cancer cells proliferation and migration, but the underlying mechanism is still limited. In this study, the anti-cancer effects as well as the detailed mechanisms of isoliquiritigenin were explored. The results proved that isoliquiritigenin could negatively regulate breast cancer growth through the induction of apoptosis. We also verified the anti-cancer effect of isoliquiritigenin on migration and invasion, and identified highly expressed miR-374a as one of the main microRNAs down-regulated by isoliquiritigenin treatment in breast cancer. Further study displayed that isoliquiritigenin increased PTEN expression through the decrease of miR-374a expression to inhibit the aberrant Akt signaling. Our findings suggest isoliquiritigenin as a novel anti-cancer candidate significantly regulating miR-374a/PTEN/Akt axis in microRNA-based breast cancer therapies.
format article
author Fu Peng
Hailin Tang
Peng Liu
Jiangang Shen
Xinyuan Guan
Xiaofang Xie
Jihai Gao
Liang Xiong
Lei Jia
Jianping Chen
Cheng Peng
author_facet Fu Peng
Hailin Tang
Peng Liu
Jiangang Shen
Xinyuan Guan
Xiaofang Xie
Jihai Gao
Liang Xiong
Lei Jia
Jianping Chen
Cheng Peng
author_sort Fu Peng
title Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_short Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_full Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_fullStr Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_full_unstemmed Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis
title_sort isoliquiritigenin modulates mir-374a/pten/akt axis to suppress breast cancer tumorigenesis and metastasis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/cbd7dca5bb244ff581355a22a01d6f85
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