SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

Intermittent fasting has been shown to have beneficial effects on hippocampal function in rodents, but the underlying mechanism is not fully understood. Here the authors show that the mitochondrial protein SIRT3 contributes to the beneficial cognitive and synaptic effects of intermittent fasting in...

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Autores principales:	Yong Liu, Aiwu Cheng, Yu-Jiao Li, Ying Yang, Yuki Kishimoto, Shi Zhang, Yue Wang, Ruiqian Wan, Sophia M. Raefsky, Daoyuan Lu, Takashi Saito, Takaomi Saido, Jian Zhu, Long-Jun Wu, Mark P. Mattson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cbdb31d971724064a184d9a5ad197134
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spelling	oai:doaj.org-article:cbdb31d971724064a184d9a5ad1971342021-12-02T17:01:28ZSIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice10.1038/s41467-019-09897-12041-1723https://doaj.org/article/cbdb31d971724064a184d9a5ad1971342019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09897-1https://doaj.org/toc/2041-1723Intermittent fasting has been shown to have beneficial effects on hippocampal function in rodents, but the underlying mechanism is not fully understood. Here the authors show that the mitochondrial protein SIRT3 contributes to the beneficial cognitive and synaptic effects of intermittent fasting in mice.Yong LiuAiwu ChengYu-Jiao LiYing YangYuki KishimotoShi ZhangYue WangRuiqian WanSophia M. RaefskyDaoyuan LuTakashi SaitoTakaomi SaidoJian ZhuLong-Jun WuMark P. MattsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yong Liu Aiwu Cheng Yu-Jiao Li Ying Yang Yuki Kishimoto Shi Zhang Yue Wang Ruiqian Wan Sophia M. Raefsky Daoyuan Lu Takashi Saito Takaomi Saido Jian Zhu Long-Jun Wu Mark P. Mattson SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
description	Intermittent fasting has been shown to have beneficial effects on hippocampal function in rodents, but the underlying mechanism is not fully understood. Here the authors show that the mitochondrial protein SIRT3 contributes to the beneficial cognitive and synaptic effects of intermittent fasting in mice.
format	article
author	Yong Liu Aiwu Cheng Yu-Jiao Li Ying Yang Yuki Kishimoto Shi Zhang Yue Wang Ruiqian Wan Sophia M. Raefsky Daoyuan Lu Takashi Saito Takaomi Saido Jian Zhu Long-Jun Wu Mark P. Mattson
author_facet	Yong Liu Aiwu Cheng Yu-Jiao Li Ying Yang Yuki Kishimoto Shi Zhang Yue Wang Ruiqian Wan Sophia M. Raefsky Daoyuan Lu Takashi Saito Takaomi Saido Jian Zhu Long-Jun Wu Mark P. Mattson
author_sort	Yong Liu
title	SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
title_short	SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
title_full	SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
title_fullStr	SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
title_full_unstemmed	SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice
title_sort	sirt3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in app mutant mice
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cbdb31d971724064a184d9a5ad197134
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SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

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