Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders

Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels.

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Autores principales:	Yao Xiao, Can Wang, Jia-Yu Chen, Fujian Lu, Jue Wang, Ning Hou, Xiaomin Hu, Fanxin Zeng, Dongwei Ma, Xueting Sun, Yi Ding, Yan Zhang, Wen Zheng, Yuli Liu, Haibao Shang, Wenzhen Zhu, Chensheng Han, Yulin Zhang, Kunfu Ouyang, Liangyi Chen, Ju Chen, Rui-Ping Xiao, Chuan-Yun Li, Xiuqin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cbdb7808618149698d196802ee3bf15d
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spelling	oai:doaj.org-article:cbdb7808618149698d196802ee3bf15d2021-12-02T16:49:18ZDeficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders10.1038/s41467-018-04352-z2041-1723https://doaj.org/article/cbdb7808618149698d196802ee3bf15d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04352-zhttps://doaj.org/toc/2041-1723Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels.Yao XiaoCan WangJia-Yu ChenFujian LuJue WangNing HouXiaomin HuFanxin ZengDongwei MaXueting SunYi DingYan ZhangWen ZhengYuli LiuHaibao ShangWenzhen ZhuChensheng HanYulin ZhangKunfu OuyangLiangyi ChenJu ChenRui-Ping XiaoChuan-Yun LiXiuqin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao Xiao Can Wang Jia-Yu Chen Fujian Lu Jue Wang Ning Hou Xiaomin Hu Fanxin Zeng Dongwei Ma Xueting Sun Yi Ding Yan Zhang Wen Zheng Yuli Liu Haibao Shang Wenzhen Zhu Chensheng Han Yulin Zhang Kunfu Ouyang Liangyi Chen Ju Chen Rui-Ping Xiao Chuan-Yun Li Xiuqin Zhang Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
description	Hyperinsulinemia can precede the development of insulin resistance. Here the authors identify a PKD2 mutation that leads to hyperinsulinemia and insulin resistance in Rhesus monkey and show that PKD2 deficiency promotes beta cell insulin secretion by activating L-type Ca2+ channels.
format	article
author	Yao Xiao Can Wang Jia-Yu Chen Fujian Lu Jue Wang Ning Hou Xiaomin Hu Fanxin Zeng Dongwei Ma Xueting Sun Yi Ding Yan Zhang Wen Zheng Yuli Liu Haibao Shang Wenzhen Zhu Chensheng Han Yulin Zhang Kunfu Ouyang Liangyi Chen Ju Chen Rui-Ping Xiao Chuan-Yun Li Xiuqin Zhang
author_facet	Yao Xiao Can Wang Jia-Yu Chen Fujian Lu Jue Wang Ning Hou Xiaomin Hu Fanxin Zeng Dongwei Ma Xueting Sun Yi Ding Yan Zhang Wen Zheng Yuli Liu Haibao Shang Wenzhen Zhu Chensheng Han Yulin Zhang Kunfu Ouyang Liangyi Chen Ju Chen Rui-Ping Xiao Chuan-Yun Li Xiuqin Zhang
author_sort	Yao Xiao
title	Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
title_short	Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
title_full	Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
title_fullStr	Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
title_full_unstemmed	Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
title_sort	deficiency of prkd2 triggers hyperinsulinemia and metabolic disorders
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cbdb7808618149698d196802ee3bf15d
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Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders

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